A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Brd8

General Information
SymbolDmel\Brd8SpeciesD. melanogaster
NameBrd8Annotation symbolCG14514
Feature typeprotein_coding_geneFlyBase IDFBgn0039654
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map99A1-99A1Sequence location3R:25,049,213..25,052,006 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol Brd8 (CG14514, FBgn0039654). It has the cytological map location 99A1. Its sequence location is 3R:25049213..25052006. Its molecular function is unknown. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
99A1-99A1  
Limits computationally determined from genome sequence between P{PZ}l(3)0470804708 and P{PZ}l(3)0674306743  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Brd8 for information on other features
detailed view FBtr0085392 FBtr0085393 FBtr0085405 FBtr0085394 FBtr0113305 FBpp0084762 FBpp0084761 FBpp0084774 FBpp0084763 FBpp0112217 FBti0043484 FBti0049758 FBti0040904
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Brd8-RA
FBtr0085394
 NM_143428
  2794
  872
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Brd8-PA  
FBpp0084763  
94.2  
872  
4.88  
  NP_651685
  AAF56879
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Bromodomain (IPR001487)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA695763
 
AA942487
 
AE003768
AAF56879
 
AI260474
 
AI512848
 
AI530783
 
AI541665
 
AI542656
 
AI544081
 
AI546607
 
AW944543
 
AY069837
AAL39982
 
BG635875
 
BG639185
 
BI162905
 
BI163647
 
BI165698
 
BI368960
 
BI484543
 
BI636127
 
BI637533
 
DQ138800
ABA86406
 
EC255795
 
EL879920
 
LD46310
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of Brd8ClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of Brd8ClassMutagenStocksKnown lesion
        Brd8GD169803 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        Disrupted in
        (Ryder, 2004.4.26)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD16980}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 0 )
        hide Molecular Function
        CV term
        Evidence
        References
        hide Biological Process
        CV term
        Evidence
        References
        hide Cellular Component
        CV term
        Evidence
        References
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Brd8 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
        (Comeron and Guthrie, 2005.7.21)
         
        (Comeron and Guthrie, 2005.7.21)
        (Comeron and Guthrie, 2005.7.21)
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 3 )
        VDRC
        v49990
        w1118; P{GD16980}v49990
        v52636
        w1118; P{GD16980}v52636
        v49989
        w1118; P{GD16980}v49989/CyO
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 18 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: Brd8 CG14514
        (Kusch et al., 2004)
        Source for database merge of
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Bromodomain (IPR001487)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 3 )
        Reported As
        Symbol Synonym
        Brd8
         
        CG14514
        (Kusch et al., 2004, Giot et al., 2003, )
        dBrd8
        (Kusch et al., 2004, Jin, 2005)
        Name Synonym
        Brd8
         
        Secondary FlyBase IDs
          hide References ( 11 )
          Supplementary material
          Kusch et al., 2004, Science 306(5704):
          Supporting online material for; Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions. [FBrf0185743]
          Giot et al., 2003, Science 302(5651):
          Tables S1 to S7. [FBrf0166452]
          Review
          Raisner, 2006, Curr. Opin. Genet. Dev. 16(2): 119--124
          [title not yet available] [FBrf0191593]
          Jin, 2005, Trends Biochem. Sci. 30(12): 680--687
          [FBrf0199097]
          Personal communication to FlyBase
          Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
          RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
          Ryder, 2004.4.26, Exelixis CG deletion data.
          Exelixis CG deletion data. [FBrf0184335]
          Computer file
          BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
          Berkeley Drosophila Genome Project. [FBrf0125078]
          DNA/RNA sequence record
          Comeron and Guthrie, 2005.7.21, GenBank/EMBL/DDBJ: DQ138801
          Drosophila simulans strain Ky-a CG14514 gene, partial cds. [FBrf0197425]
          Comeron and Guthrie, 2005.7.21, GenBank/EMBL/DDBJ: DQ138803
          Drosophila yakuba strain Tai18 CG14514 gene, partial cds. [FBrf0197426]
          Comeron and Guthrie, 2005.7.21, GenBank/EMBL/DDBJ: DQ138805
          Drosophila erecta voucher stock #14021-0224.0 CG14514 gene, partial cds. [FBrf0197427]
          Automatic genome annotation
          FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]
          [Annotations performed at the Celera Jamboreee.] [FBrf0126705]