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Gene Dmel\Ccap

General Information
Symbol	Dmel\Ccap	Species	D. melanogaster
Name	Cardioacceleratory peptide	Annotation symbol	CG4910
Feature type	protein_coding_gene	FlyBase ID	FBgn0039007
Created / Updated	2003-12-01/2006-05-09
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94C1-94C1	Sequence location	3R:18,526,304..18,527,806 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cardioacceleratory peptide is referred to in FlyBase by the symbol Ccap (CG4910, FBgn0039007). It has the cytological map location 94C1. Its sequence location is 3R:18526304..18527806. Its molecular function is described as neuropeptide hormone activity. It is involved in the biological processes: neuropeptide signaling pathway; positive regulation of heart contraction; regulation of heart contraction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94C1-94C1   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Ccap for information on other features
Comments on Gene Model
	FlyBase records homologous protein in Manduca Sexta, but this is not mentioned in apollo.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ccap-RA FBtr0084333  NM_142826   1249   155
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Ccap-PA   FBpp0083726   18.0   155   8.90     NP_651083   AAF56045
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003740 AAF56045   BT024429   CK134592   EL870482   EL870483
UniProtKB/Swiss-Prot	Q9VCW0
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 10399
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0039007 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0039007
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CcapEY15558 Sterility Allele fertile CcapEY15558 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ccap Class Mutagen Stocks Known lesion CcapEY15558 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ccap Class Mutagen Stocks Known lesion CcapGD6801 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(3R)hh
Useful duplication	Dp(3;3)M95A+13
Disrupted in	Df(3R)Exel6192 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6801} NA characterization construct P{Ccap-GAL80.L} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CcapEY15558 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 5 )
Molecular Function
CV term Evidence References
neuropeptide hormone activity inferred from sequence or structural similarity (vanden Broeck, 2001) inferred from sequence or structural similarity with UniProtKB:Q8WRC7 (Dewey et al., 2004) inferred from sequence or structural similarity with EMBL:AF071800 (FlyBase, 1992-) non-traceable author statement (Hewes and Taghert, 2001)
Biological Process
CV term Evidence References
neuropeptide signaling pathway inferred from sequence or structural similarity (vanden Broeck, 2001)
positive regulation of heart contraction inferred from sequence or structural similarity with UniProtKB:Q7KRY7 AND inferred from sequence or structural similarity with UniProt:Q8WRC7 (Dewey et al., 2004)
regulation of heart contraction inferred from sequence or structural similarity with EMBL:AF071800 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with UniProtKB:Q7KRY7 AND inferred from sequence or structural similarity with UniProt:Q8WRC7 (Dewey et al., 2004)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ccap allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 67633
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16697 Dere\GG12496 Dgri\GH18507 Dmoj\GI24352 Dper\GL23784 Dpse\GA18518 Dsec\GM23628 Dsim\GD18435 Dvir\GJ24364 Dwil\GK11630 Dyak\GE24016
Curated drosophilid orthologs	Dpse\GA18518
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000010131 Anopheles gambiae (Ensembl)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	21144 y1 w67c23; P{EPgy2}CcapEY15558
Genomic Clones ( 2 )
	BACR02L12 BACR23F10
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP02558
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP02560 RE68888
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0039007 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0039007
Antibody Information
	y (Dewey et al., 2004)
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: Ccap CG4910 (Ewer, 2001.3.5)
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142826 RefSeq (Proteins) • NP_651083 DDBJ / EMBL / GenBank • AE003740 AAF56045 UniProtKB/Swiss-Prot • Q9VCW0
Other Crossreferences
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 67633 DEDB - Drosophila exon database: splicing graphs • 10399 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0039007 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0039007 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039007 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0039007 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0039007 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000010131 Anopheles gambiae (Ensembl) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/ccap1.htm
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CCAP (Luan et al., 2006, Zhang et al., 2000, Casci, 2004, Park et al., 2004, Johnson et al., 2003, Hewes et al., 2003, Peterson et al., 2002, vanden Broeck, 2001, Ewer et al., 2001, Hoose et al., 2006, Luan et al., 2006, Davis et al., 2007, Luan et al., 2007, Peabody et al., 2007, Kim et al., 2006, Ewer, 2006, Luan et al., 2006) Ccap   ccap (Melcher and Pankratz, 2005) CG4910 (Vanden Broeck et al., 2001, ) DmCCAP (Park et al., 2003)
Name Synonym	Cardioacceleratory peptide (Park et al., 2003) Crustacean Cardioactive Peptide (Ewer et al., 2004, Peabody et al., 2007) crustacean cardioactive peptide (Davis et al., 2007, Kim et al., 2006)
Secondary FlyBase IDs
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 3 ) Review  ( 7 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) Computer file  ( 1 )
Recent research papers ( 3 )
	Kim et al., 2006, Curr. Biol. 16(13): 1395--1407 A command chemical triggers an innate behavior by sequential activation of multiple peptidergic ensembles. [FBrf0194317] Luan et al., 2006, J. Neurosci. 26(2): 573--584 Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. [FBrf0191050] Luan et al., 2006, Neuron 52(3): 425--436 Refined spatial manipulation of neuronal function by combinatorial restriction of transgene expression. [FBrf0193617] Show all research papers ...
Recent reviews ( 1 )
	Ewer, 2006, Curr. Biol. 16(17): R682--R684 Behavioral endocrinology: lighting up peptidergic neurons that mediate a complex behavior. [FBrf0198725] Show all reviews ...