Gene Dmel\CG33967

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General Information

Symbol

Dmel\CG33967

Species

D. melanogaster

Name

CG33967

Annotation symbol

CG33967

Feature type

protein_coding_gene

FlyBase ID

FBgn0053967

Created / Updated

2005-09-09/2005-09-09

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

88D1-88D1

Sequence location

3R:10,524,252..10,549,978 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG33967 (FBgn0053967). It has the cytological map location 88D1. Its sequence location is 3R:10524252..10549978. Its molecular function is described as protein binding. The biological processes in which it is involved are not known. 11 alleles are reported. The phenotype of these alleles is annotated with eye. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88D1-88D1

Limits computationally determined from genome sequence between P{PZ}put¹⁰⁴⁶⁰ and P{EP}CG33967^EP666

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG33967 for information on other features

Comments on Gene Model

Gene merge based on EST/cDNA data

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG33967-RA

FBtr0100008

NM_001038966

4904

1288

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG33967-PA

FBpp0099467

144.4

1288

5.79

NP_001034055

AAF55090

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

C2 calcium-dependent membrane targeting (IPR000008)

WW/Rsp5/WWP (IPR001202)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VFG8

Maps to

Does NOT map to

Identified with

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI546676
AI533489

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

CG33967^EY03746

lethal

CG33967^CB04401

Other Phenotypes

Allele

visible, with Scer\GAL4^GMR.PF

CG33967^EP666

visible, with Scer\GAL4^ey.PH

Sterility

Allele

fertile

CG33967^EY03746

Phenotype manifest in

Allele

eye, with Scer\GAL4^ey.PH

eye, with Scer\GAL4^GMR.PF

CG33967^EP666

Classical Alleles ( 9 )

For All Classical Alleles Show

Allele of CG33967	Mutagen	Stocks	Known lesion
CG33967^CB04401	P-element activity	0	Yes
CG33967^EP3205	P-element activity	1	--
CG33967^EP3494	P-element activity	1	--
CG33967^EP666	P-element activity	1	--
CG33967^EP747	P-element activity	1	--
CG33967^EY03746	P-element activity	1	--
CG33967^d05870	P-element activity	1	--
CG33967^d09379	P-element activity	1	--
CG33967^d10187	P-element activity	0	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG33967	Class	Mutagen	Stocks	Known lesion
CG33967^GD13715		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
CG33967^GD7772		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)red-P1

Disrupted in

Df(3R)Exel8160

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD13715}

P{GD7772}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{PTT-GB}CG33967^CB04401

insertion of enhancer trap binary system

P{GawB}ckm78

insertion of mobile activating element

P{EPgy2}CG33967^EY03746

Related Comments

Please look at the allele reports for the complete phenotype data

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

protein binding

inferred from electronic annotation with InterPro:IPR001202

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

biological_process

no biological data available

(FlyBase Curators, 2002-)

Cellular Component

CV term

Evidence

References

cellular_component

no biological data available

(FlyBase Curators, 2002-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG33967 allele

Gene

References

CG33967^EP666

pnr

(Pena-Rangel et al., 2002)

CycE

(Tseng and Hariharan, 2002)

CG33967^EP747

pnr

(Pena-Rangel et al., 2002)

unspecified

(Mueller et al., 2005)

External Data

Linkouts

Orthologs

Genome-wide drosophilid orthologs

Dana\GF18133

Dere\GG21121

Dgri\GH14353

Dmoj\GI10447

Dper\GL23671

Dpse\GA26695

Dsec\GM25831

Dsim\GD20405

Dvir\GJ10664

Dwil\GK11691

Dyak\GE26432

Curated drosophilid orthologs

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000020424
Anopheles gambiae (Ensembl)
ENSBTAP00000016172
Bos taurus (Ensembl)
ENSCAFP00000025165
Canis familiaris (Ensembl)
ENSCINP00000004870
Ciona intestinalis (Ensembl)
NEWSINFRUP00000172544
Takifugu rubripes (Ensembl)
ENSGALP00000017336
Gallus gallus (Ensembl)
ENSP00000265293
Homo sapiens (Ensembl)
ENSMMUP00000009784
Macaca mulatta (Ensembl)
ENSMODP00000009162
Monodelphis domestica (Ensembl)
ENSPTRP00000029906
Pan troglodytes (Ensembl)
ENSRNOP00000017966
Rattus norvegicus (Ensembl)
GSTENP00014581001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000034336
Xenopus tropicalis (Ensembl)
MGI:2388637
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 13 )

v31992

w¹¹¹⁸ P{GD7772}v31992

v31993

w¹¹¹⁸ P{GD7772}v31993

v28835

w¹¹¹⁸; P{GD13715}v28835

v28836

w¹¹¹⁸; P{GD13715}v28836

More stocks available...

Genomic Clones ( 2 )

cDNA Clones ( 20 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE26350

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0053967

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: CG7552 CG12600 Annotations CG7552 and CG12600 merged as CG33967 in release 4.3 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_001038966

RefSeq (Proteins)

•

NP_001034055

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q9VFG8

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

C2 calcium-dependent membrane targeting (IPR000008)

WW/Rsp5/WWP (IPR001202)

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0053967

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0053967

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000020424
Anopheles gambiae (Ensembl)
ENSBTAP00000016172
Bos taurus (Ensembl)
ENSCAFP00000025165
Canis familiaris (Ensembl)
ENSCINP00000004870
Ciona intestinalis (Ensembl)
NEWSINFRUP00000172544
Takifugu rubripes (Ensembl)
ENSGALP00000017336
Gallus gallus (Ensembl)
ENSP00000265293
Homo sapiens (Ensembl)
ENSMMUP00000009784
Macaca mulatta (Ensembl)
ENSMODP00000009162
Monodelphis domestica (Ensembl)
ENSPTRP00000029906
Pan troglodytes (Ensembl)
ENSRNOP00000017966
Rattus norvegicus (Ensembl)
GSTENP00014581001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000034336
Xenopus tropicalis (Ensembl)
MGI:2388637
Mus musculus (Informatics)

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

CG7552

(Mueller et al., 2005, Ringrose et al., 2003, Mirth and Akam, 2002, Tseng and Hariharan, 2002, Pena-Rangel et al., 2002, Giot et al., 2003, Sun et al., 2006)

CG12600

CG33967

(Buszczak et al., 2007)

RE26350

(Pena-Rangel et al., 2002)

Name Synonym

CG33967

Secondary FlyBase IDs

FBgn0038254
FBgn0038255
FBtr0082970
FBpp0082429
FBtr0083022
FBpp0082481

References ( 19 )

Research paper

Buszczak et al., 2007, Genetics 175(3): 1505--1531: The Carnegie protein trap library: A versatile tool for Drosophila developmental studies. [FBrf0200345]
Sun et al., 2006, Genetics 173(3): 1397--1415: Glial and neuronal functions of the Drosophila homolog of the human SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the lateral positioning of longitudinal glia and axons. [FBrf0194564]
Mueller et al., 2005, Genetics 171(3): 1137--1152: Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751]
Ringrose et al., 2003, Dev. Cell 5(5): 759--771: Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. [FBrf0167478]
Mirth and Akam, 2002, Dev. Biol. 246(2): 391--406: Joint development in the Drosophila leg: cell movements and cell populations. [FBrf0148940]
Pena-Rangel et al., 2002, Genetics 160(3): 1035--1050: A misexpression study examining dorsal thorax formation in Drosophila melanogaster. [FBrf0147055]
Tseng and Hariharan, 2002, Genetics 162(1): 229--243: An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. [FBrf0152035]

Supplementary material

Boutros et al., 2004, Science 303(5659):: Supporting Online Material: Figures S1 to S8; Tables S1 to S6. [FBrf0174218]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of Inter