A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\CG6359

General Information
SymbolDmel\CG6359SpeciesD. melanogaster
NameCG6359Annotation symbolCG6359
Feature typeprotein_coding_geneFlyBase IDFBgn0038065
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map87C3-87C3Sequence location3R:8,453,763..8,455,790 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol CG6359 (FBgn0038065). It has the cytological map location 87C3. Its sequence location is 3R:8453763..8455790. Its molecular function is described as: phosphoinositide binding; protein binding. It is involved in the biological processes: intracellular protein transport; phagocytosis, engulfment; cell communication. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
87C3-87C3  
Limits computationally determined from genome sequence between P{lacW}Vha55j2E9 and P{PZ}CtBP03463  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\CG6359 for information on other features
detailed view FBtr0082671 FBtr0082670 FBtr0082641 FBtr0082643 FBpp0082139 FBpp0082140 FBpp0082110 FBpp0082112 FBti0004321 FBti0099875 FBti0051451 FBti0039252 FBti0067156 FBti0041737 FBti0051433
Comments on Gene Model
EST data support existence of multiple transcripts due to variable use of 5' exons
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
CG6359-RA
FBtr0082641
 NM_141957
  1423
  167
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
CG6359-PA  
FBpp0082110  
19.4  
167  
9.64  
  NP_650214
  AAF54838
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Phox-like (IPR001683)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA390924
 
AA696627
 
AA803102
 
AA949625
 
AE003696
AAF54838
 
AE003696
AAN13550
 
AI109452
 
AI135053
 
AI135428
 
AI258888
 
AI296948
 
AI297044
 
AI388623
 
AI405413
 
AI514685
 
AY071431
AAL49053
 
BE977773
 
BE977901
 
BE978530
 
BF491134
 
BF496880
 
BF498689
 
BF505060
 
BF506773
 
BG634994
 
BI169293
 
BI237501
 
BI237813
 
BI237907
 
BI242840
 
BI366482
 
BI369051
 
BI567434
 
BI580357
 
BI580638
 
BI628578
 
BI635382
 
BI637556
 
CL527821
 
CO178929
 
CO185513
 
CO186699
 
CO261928
 
CO267664
 
CO268613
 
CO268721
 
CO278587
 
CO287591
 
CO298905
 
CO307064
 
CO319138
 
CO329651
 
DN153967
 
EC059588
 
EC061430
 
EC067058
 
EC078002
 
EC078535
 
EC084683
 
EC195880
 
EC196130
 
EC198723
 
EC203555
 
EC205929
 
EC208333
 
EC208334
 
EC232481
 
EC236518
 
EC239343
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0082671 FBtr0082670 FBtr0082641 FBtr0082643
        AI403977
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        Sterility
        Allele
        fertile
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of CG6359ClassMutagenStocksKnown lesion
        CG6359EY056881 --
        hide Alleles Carried on Transgenic Constructs ( 2 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of CG6359ClassMutagenStocksKnown lesion
        CG6359GD105692 Yes
        CG6359GD170110 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        Disrupted in
        (Ryder, 2004.4.26)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD10569}
        NA
        P{GD17011}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        insertion of mobile activating element
        P{EPgy2}CG6359EY05688
        NA
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
        (Stroschein-Stevenson et al., 2006)
        hide Gene Ontology: Function, Process & Cellular Component ( 5 )
        hide Molecular Function
        CV term
        Evidence
        References
        phosphoinositide binding
        inferred from electronic annotation with InterPro:IPR001683
        (FlyBase Curators et al., 2004-)
        protein binding
        inferred from electronic annotation with InterPro:IPR001683
        (FlyBase Curators et al., 2004-)
        hide Biological Process
        CV term
        Evidence
        References
        cell communication
        inferred from electronic annotation with InterPro:IPR001683
        (FlyBase Curators et al., 2004-)
        intracellular protein transport
        inferred from sequence or structural similarity with EMBL:AF062484
        (FlyBase, 1992-)
        phagocytosis, engulfment
        inferred from mutant phenotype
        (Stroschein-Stevenson et al., 2006)
        hide Cellular Component
        CV term
        Evidence
        References
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        CG6359 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 3 )
        VDRC
        v34166
        w1118 P{GD10569}v34166
        v34165
        w1118; P{GD10569}v34165/CyO
        Bloomington
        16668
        y1 w67c23; P{EPgy2}CG6359EY05688
        hide Genomic Clones ( 2 )
        hide cDNA Clones ( 48 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Phox-like (IPR001683)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        University of Chicago Dev. Expression
        •
        hide Synonyms & Secondary IDs ( 1 )
        Reported As
        Symbol Synonym
        CG6359
        (Stroschein-Stevenson et al., 2006)
        Name Synonym
        CG6359
         
        Secondary FlyBase IDs
          hide References ( 10 )
          Research paper
          Stroschein-Stevenson et al., 2006, PLoS Biol. 4(1): 87--99
          Identification of Drosophila gene products required for phagocytosis of Candida albicans. [FBrf0191376]
          Supplementary material
          Dietzl et al., 2007, Nature 448(7150):
          Supplementary Table 1. [FBrf0202579]
          Giot et al., 2003, Science 302(5651):
          Tables S1 to S7. [FBrf0166452]
          Personal communication to FlyBase
          Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
          RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
          FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
          Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
          Ryder, 2004.4.26, Exelixis CG deletion data.
          Exelixis CG deletion data. [FBrf0184335]
          FlyBase analysis
          FlyBase, 1992-, FlyBase curation
          FlyBase curation. [FBrf0105495]
          Computer file
          Gene Disruption Project members, 2001-, [title not yet available]
          [title not yet available] [FBrf0132177]
          BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
          Berkeley Drosophila Genome Project. [FBrf0125078]
          Curated genome annotation
          Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.]
          [Annotations performed at the Celera Jamboreee.] [FBrf0126677]