Gene Dmel\Tk

Help

Close All Open All

General Information

Symbol

Dmel\Tk

Species

D. melanogaster

Name

Tachykinin

Annotation symbol

CG14734

Feature type

protein_coding_gene

FlyBase ID

FBgn0037976

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

87A4-87A4

Sequence location

3R:7,819,897..7,831,194 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Tachykinin is referred to in FlyBase by the symbol Tk (CG14734, FBgn0037976). It has the cytological map location 87A4. Its sequence location is 3R:7819897..7831194. Its molecular function is described as: receptor binding; neuropeptide hormone activity. It is involved in the biological process neuropeptide signaling pathway. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87A4-87A4

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

(Siviter, 2000.3.22)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Tk for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Tk-RA

FBtr0082488

NM_141884

1596

289

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Tk-PA

FBpp0081962

31.7

289

8.79

NP_650141

AAF54735

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

(Siviter et al., 2000)

Does NOT map to

Identified with

RE23085

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

9124

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037976

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0037976

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0037976

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 5 )

For All Classical Alleles Show

Allele of Tk	Mutagen	Stocks	Known lesion
Tk^EY20174	P-element activity	1	--
Tk^c01416	piggyBac transposase	1	--
Tk^d11490	P-element activity	1	--
Tk^f03824	piggyBac transposase	1	--
Tk^f06233	piggyBac transposase	2	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Tk	Class	Mutagen	Stocks	Known lesion
Tk^GD13277		in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)E229

Useful duplication

Dp(3;3)D1a

Disrupted in

Df(3R)Exel6162

(Ryder, 2004.4.26)

Df(3R)Exel7312

(Ryder, 2004.4.26)

Df(3R)Exel8155

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD13277}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

insertion of mobile activating element

P{EPgy2}Tk^EY20174

P{XP}Tk^d11490

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

neuropeptide hormone activity

inferred from sequence or structural similarity

(vanden Broeck, 2001)

receptor binding

non-traceable author statement

(Siviter, 2000.3.22)

non-traceable author statement

(Hewes and Taghert, 2001)

Biological Process

CV term

Evidence

References

neuropeptide signaling pathway

inferred from sequence or structural similarity

(vanden Broeck, 2001)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Tk allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

66573

Orthologs

Genome-wide drosophilid orthologs

Dana\GF17753

Dere\GG17170

Dgri\GH12475

Dmoj\GI24061

Dper\GL21585

Dpse\GA13208

Dsec\GM26049

Dsim\GD20612

Dvir\GJ23687

Dwil\GK11666

Dyak\GE24560

Curated drosophilid orthologs

Dpse\GA13208

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 7 )

22368

y¹ w^67c23; P{EPgy2}Tk^EY20174

12943

y¹ w^67c23; P{SUPor-P}KG03257 ry⁵⁰⁶

18951

w¹¹¹⁸; PBac{WH}Tk^f06233 Ect3^f06233/TM6B, Tb¹

Genomic Clones ( 2 )

cDNA Clones ( 120 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE23085

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones