Gene Dmel\CG10585

Help

Close All Open All

General Information

Symbol

Dmel\CG10585

Species

D. melanogaster

Name

CG10585

Annotation symbol

CG10585

Feature type

protein_coding_gene

FlyBase ID

FBgn0037044

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

78A2-78A2

Sequence location

3L:21,020,995..21,023,247 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG10585 (FBgn0037044). It has the cytological map location 78A2. Its sequence location is 3L:21020995..21023247. Its molecular function is described as trans-hexaprenyltranstransferase activity. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78A2-78A2

Limits computationally determined from genome sequence between P{EP}fng^EP3082&P{lacW}skd^L7062 and P{lacW}l(3)L5541^L5541

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG10585 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG10585-RA

FBtr0078287

NM_141020

2016

448

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG10585-PA

FBpp0077945

49.4

448

6.80

NP_649277

AAF51668

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0037044

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Terpenoid synthase (IPR008949)

Polyprenyl synthetase-related (IPR017446)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VP87

Maps to

Does NOT map to

Identified with

GH23839

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5962

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI404209

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037044

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0037044

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0037044

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for CG10585

Stage(s) 11-12

Stage(s) 13-16

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

CG10585^EY12050

Sterility

Allele

fertile

CG10585^EY12050

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of CG10585	Mutagen	Stocks	Known lesion
CG10585^EY00037	P-element activity	1	--
CG10585^EY12050	P-element activity	1	--
CG10585^GS6087		0	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG10585	Class	Mutagen	Stocks	Known lesion
CG10585^GD7029		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3L)Pc-MK

Useful duplication

Dp(3;3)M72

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD7029}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}KG02102

insertion of mobile activating element

P{EPgy2}CG10585^EY00037

P{EPgy2}CG10585^EY12050

P{EP}skd^EP3375

P{EP}skd^EP3443

P{GSV3}CG10585^GS6087

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 1 )

Molecular Function

CV term

Evidence

References

trans-hexaprenyltranstransferase activity

inferred from sequence or structural similarity with SGD_LOCUS:COQ1; SGD:S0000207

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG10585 allele

Gene

References

unspecified

Nsf2

(Laviolette et al., 2005)

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

65576

Orthologs

Genome-wide drosophilid orthologs

Dana\GF24292

Dere\GG16155

Dgri\GH15641

Dmoj\GI12688

Dper\GL24462

Dpse\GA10416

Dsec\GM22336

Dsim\GD14926

Dvir\GJ12673

Dwil\GK25396

Dyak\GE23254

Curated drosophilid orthologs

Dpse\GA10416

Dyak\GE23254

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000005832
Anopheles gambiae (Ensembl)
ENSBTAP00000029142
Bos taurus (Ensembl)
ENSCAFP00000005568
Canis familiaris (Ensembl)
ENSCINP00000005299
Ciona intestinalis (Ensembl)
NEWSINFRUP00000135541
Takifugu rubripes (Ensembl)
ENSGALP00000024670
Gallus gallus (Ensembl)
ENSP00000296990
Homo sapiens (Ensembl)
ENSMMUP00000003035
Macaca mulatta (Ensembl)
ENSMODP00000022465
Monodelphis domestica (Ensembl)
ENSPTRP00000031540
Pan troglodytes (Ensembl)
ENSRNOP00000049086
Rattus norvegicus (Ensembl)
GSTENP00016973001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000041737
Xenopus tropicalis (Ensembl)
ZDB-CDNA-040718-56
Danio rerio (Zfin)
ZDB-GENE-040718-43
Danio rerio (Zfin)
MGI:1918615
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 7 )

v31272

w¹¹¹⁸; P{GD7029}v31272

v31273

w¹¹¹⁸; P{GD7029}v31273

Bloomington

14801

y¹ w^67c23; P{EPgy2}CG10585^EY00037

20725

y¹ w^67c23; P{EPgy2}CG10585^EY12050

14417

y¹ w^67c23; P{SUPor-P}KG02102 ry⁵⁰⁶

Genomic Clones ( 1 )

BACR03J02

cDNA Clones ( 28 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

GH23839

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0037044

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0037044

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_141020

RefSeq (Proteins)

•

NP_649277

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q9VP87

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Terpenoid synthase (IPR008949)

Polyprenyl synthetase-related (IPR017446)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

65576

DEDB - Drosophila exon database: splicing graphs

•

5962

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0037044

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037044

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0037044

FlyExpress - Embryonic expression images (BDGP data)

•

FBgn0037044

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0037044

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0037044

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0037044

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000005832
Anopheles gambiae (Ensembl)
ENSBTAP00000029142
Bos taurus (Ensembl)
ENSCAFP00000005568
Canis familiaris (Ensembl)
ENSCINP00000005299
Ciona intestinalis (Ensembl)
NEWSINFRUP00000135541
Takifugu rubripes (Ensembl)
ENSGALP00000024670
Gallus gallus (Ensembl)
ENSP00000296990
Homo sapiens (Ensembl)
ENSMMUP00000003035
Macaca mulatta (Ensembl)
ENSMODP00000022465
Monodelphis domestica (Ensembl)
ENSPTRP00000031540
Pan troglodytes (Ensembl)
ENSRNOP00000049086
Rattus norvegicus (Ensembl)
GSTENP00016973001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000041737
Xenopus tropicalis (Ensembl)
ZDB-CDNA-040718-56
Danio rerio (Zfin)
ZDB-GENE-040718-43
Danio rerio (Zfin)
MGI:1918615
Mus musculus (Informatics)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0037044

University of Chicago Dev. Expression

•

FBgn0037044

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG10585

(Laviolette et al., 2005)

Name Synonym

CG10585

Secondary FlyBase IDs

References ( 7 )

Research paper

Laviolette et al., 2005, Genetics 170(2): 779--792: A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. [FBrf0187645]

Supplementary material

Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

Computer file

Gene Disruption Project members, 2001-, [title not yet available]: [title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]

Automatic genome annotation

FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126705]