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Gene Dmel\Taspase1

General Information
Symbol	Dmel\Taspase1	Species	D. melanogaster
Name	Taspase 1	Annotation symbol	CG5241
Feature type	protein_coding_gene	FlyBase ID	FBgn0036564
Created / Updated	2003-12-01/2008-06-26
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	72D1-72D4	Sequence location	3L:16,078,979..16,080,610 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Taspase 1 is referred to in FlyBase by the symbol Taspase1 (CG5241, FBgn0036564). It has the cytological map location 72D1-72D4. Its sequence location is 3L:16078979..16080610. Its molecular function is described as: asparaginase activity; peptidase activity. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72D1-72D4   Limits computationally determined from genome sequence between P{lacW}thj5C8&P{PZ}Mbs03802 and P{lacW}SsRβs1939
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Taspase1 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Taspase1-RA FBtr0075498  NM_140575   1486   365
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Taspase1-PA   FBpp0075253   38.7   365   6.57     NP_648832   AAF49544
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0036564
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase T2, asparaginase 2 (IPR000246)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201987   AE003528 AAF49544   AI293141   AW941570   AX094048   AX094188   AY061074 AAL28622   BI162462   BI163495   BI213846   BI214956   BI215861   BI571026   BI571865   BI636363   BI638202   CO331034   EC063256   EC065233   EC067597   EC213987   EC239611   RE01771
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VUX9
Maps to
Does NOT map to
Identified with	LD05057 (BDGP Project Members, 2000-, Capotosti et al., 2007)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 3957
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036564 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0036564 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0036564 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for CG5241 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Taspase1 Stage(s) 1-3 Stage(s) 4-6 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Taspase1 Class Mutagen Stocks Known lesion Taspase1EY05175 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Taspase1 Class Mutagen Stocks Known lesion Taspase1GD11588 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes
Aneuploid Aberrations
Useful deficiency	Df(3L)th102
Useful duplication	Dp(3;3)M71
Disrupted in	Df(3L)Exel6127 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}CG5241DG20803 NA insertion of mobile activating element P{EPgy2}Taspase1EY05175 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 2 )
Molecular Function
CV term Evidence References
asparaginase activity inferred from sequence or structural similarity with UniProtKB:P37595 (FlyBase, 1992-)
peptidase activity inferred from direct assay (Capotosti et al., 2007)
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Taspase1 allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 65066
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10660 Dere\GG13500 Dgri\GH14708 Dmoj\GI12255 Dper\GL25099 Dpse\GA18757 Dsec\GM24449 Dsim\GD12517 Dvir\GJ11486 Dwil\GK23937 Dyak\GE19799
Curated drosophilid orthologs	Dpse\GA18757
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000022162 Anopheles gambiae (Ensembl) ENSBTAP00000039328 Bos taurus (Ensembl) ENSCAFP00000008370 Canis familiaris (Ensembl) ENSCINP00000006904 Ciona intestinalis (Ensembl) NEWSINFRUP00000164488 Takifugu rubripes (Ensembl) ENSGALP00000014727 Gallus gallus (Ensembl) ENSP00000338624 Homo sapiens (Ensembl) ENSMMUP00000008585 Macaca mulatta (Ensembl) ENSMODP00000006205 Monodelphis domestica (Ensembl) ENSPTRP00000022739 Pan troglodytes (Ensembl) ENSRNOP00000006236 Rattus norvegicus (Ensembl) GSTENP00030830001 Tetraodon nigroviridis (Ensembl) ENSXETP00000017706 Xenopus tropicalis (Ensembl) Q7XPW3 Oryza sativa (Gramene) AT4G00590.1 Arabidopsis thaliana (Arabidopsis) WBGene00037757 Caenorhabditis briggsae (Wormbase) WBGene00010480 Caenorhabditis elegans (Wormbase) DDB0230993 Dictyostelium discoideum (Dictybase) MGI:1923062 Mus musculus (Informatics) SPAC823.09c Schizosaccharomyces pombe (Sanger)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
VDRC	v34976 w1118 P{GD11588}v34976 v34977 w1118 P{GD11588}v34977
Bloomington	15786 w1118; P{EPgy2}CG5241EY05175 21747 y1 w67c23; P{wHy}CG5241DG20803
Genomic Clones ( 1 )
	BACR25O01
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05057
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE22616 SD18016 RH07170 GH16245 RE02912 RH05834 RE21122 SD20435 RE19467
Other clones	EK297316 RE01771
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0036564 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0036564
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: Taspase1 CG5241 (Capotosti et al., 2007)
Source for database merge of	Source for merge of: CG5241 anon-WO0118547.172 Source for merge of CG5241 anon-WO0118547.172 was sequence comparison (date:051113). (FlyBase, 1996-)
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
	Area matching Drosophila EST AA201987. This EST has sequence similarity to aspariginase genes. Probable intron in gene represented by EST AA201987. (Davies, 2001.3.15) Area matching Drosophila EST AI293141. Probable intron in gene represented by EST AI293141. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140575 RefSeq (Proteins) • NP_648832 DDBJ / EMBL / GenBank • AA201987 AE003528 AAF49544 AI293141 AW941570 AX094048 AX094188 AY061074 AAL28622 UniProtKB/TrEMBL • Q9VUX9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase T2, asparaginase 2 (IPR000246)
Linkouts
	BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for CG5241 BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 65066 DEDB - Drosophila exon database: splicing graphs • 3957 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0036564 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036564 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0036564 FlyExpress - Embryonic expression images (BDGP data) • FBgn0036564 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036564 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0036564 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0036564 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000022162 Anopheles gambiae (Ensembl) ENSBTAP00000039328 Bos taurus (Ensembl) ENSCAFP00000008370 Canis familiaris (Ensembl) ENSCINP00000006904 Ciona intestinalis (Ensembl) NEWSINFRUP00000164488 Takifugu rubripes (Ensembl) ENSGALP00000014727 Gallus gallus (Ensembl) ENSP00000338624 Homo sapiens (Ensembl) ENSMMUP00000008585 Macaca mulatta (Ensembl) ENSMODP00000006205 Monodelphis domestica (Ensembl) ENSPTRP00000022739 Pan troglodytes (Ensembl) ENSRNOP00000006236 Rattus norvegicus (Ensembl) GSTENP00030830001 Tetraodon nigroviridis (Ensembl) ENSXETP00000017706 Xenopus tropicalis (Ensembl) Q7XPW3 Oryza sativa (Gramene) AT4G00590.1 Arabidopsis thaliana (Arabidopsis) WBGene00037757 Caenorhabditis briggsae (Wormbase) WBGene00010480 Caenorhabditis elegans (Wormbase) DDB0230993 Dictyostelium discoideum (Dictybase) MGI:1923062 Mus musculus (Informatics) SPAC823.09c Schizosaccharomyces pombe (Sanger) PANTHER - Protein classification by function, families, and pathways • FBgn0036564
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	anon-WO0118547.172   CG5241   Taspase1
Name Synonym	CG5241   Taspase 1   taspase 1 (Capotosti et al., 2007)
Secondary FlyBase IDs
	FBgn0062192
References ( 13 )
Research paper	Capotosti et al., 2007, Molec. Cell. Biol. 27(20): 7063--7072 Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways. [FBrf0200591]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094188 Sequence 312 from Patent WO0118547. [FBrf0150016] Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094048 Sequence 172 from Patent WO0118547. [FBrf0149860]
Patent	Davies et al., 2001, World Patent 0118547: Essential genes and assays relating thereto. [FBrf0199103]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705] Find Enzymes, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126664]