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Gene Dmel\Or69a

General Information
Symbol	Dmel\Or69a	Species	D. melanogaster
Name	Odorant receptor 69a	Annotation symbol	CG33264
Feature type	protein_coding_gene	FlyBase ID	FBgn0041622
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69F2-69F2	Sequence location	3L:12,957,460..12,960,833 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Odorant receptor 69a is referred to in FlyBase by the symbol Or69a (CG33264, FBgn0041622). It has the cytological map location 69F2. Its sequence location is 3L:12957460..12960833. Its molecular function is described as: olfactory receptor activity; odorant binding. It is involved in the biological process sensory perception of smell. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69F2-69F2   Limits computationally determined from genome sequence between P{PZ}l(3)0692406924 and P{lacW}RpS12s2783
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Or69a for information on other features
Comments on Gene Model
	Gene model based on personal communication from Hugh Robertson to FlyBase
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Or69a-RA FBtr0075901  NM_206348   1182   393 Or69a-RB FBtr0075902  NM_206347   1182   393
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Or69a-PA   FBpp0089412   45.4   393   8.55     NP_996070   AAF49864 Or69a-PB   FBpp0089413   46.1   393   9.75     NP_996069   AAN11842
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Olfactory receptor, Drosophila (IPR004117)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003539 AAF49864   AE003539 AAN11842   BD268287   BD268288   EC051911   EC052928   EC052937   EC053924   EC054414   EC054906   EL870036   EL870037   EL870038   EL870039
UniProtKB/Swiss-Prot	P82985 Q9VU27
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 4244
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041622
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Or69a Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Or69a Class Mutagen Stocks Known lesion Or69aGD553 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes Or69aGD653 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes
Aneuploid Aberrations
Useful duplication	Dp(3;3)M67C+5
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD553} NA P{GD653} NA
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 5 )
Molecular Function
CV term Evidence References
odorant binding inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-)
olfactory receptor activity non-traceable author statement (Warr and Vosshall, 2000.5.19) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.5.1) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
sensory perception of smell non-traceable author statement (Warr and Vosshall, 2000.5.19) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.5.1) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane non-traceable author statement (Warr and Vosshall, 2000.5.19) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1)
membrane inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Or69a allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 77813
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23748 Dere\GG13792 Dgri\GH14481 Dmoj\GI13636 Dper\GL24874 Dpse\Or69a Dsec\GM24619 Dsim\GD12685 Dvir\GJ13974 Dwil\GK17351 Dyak\GE20085
Curated drosophilid orthologs	Dpse\Or69a (Robertson, 2005.7.22)
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v39521 w1118; P{GD653}v39521 v43991 w1118; P{GD553}v43991 v43993 w1118; P{GD553}v43993/TM3
Genomic Clones ( 2 )
	BACR20B01 BACR08G07
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP02151 IP02149 EC054906 IP02152 EC051911 EC052928 EC052937 EC054414 EC053924 IP02150
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0041622
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: Or69b CG17902 (Warr and Vosshall, 2000.5.19)
Source for database merge of	Source for merge of: Or69a Or69b (Robertson, 2003.6.24) Source for merge of: Or69a CG32116 Source for merge of Or69a CG32116 was sequence comparison (date:030716). (FlyBase, 1996-)
Additional comments	Annotations CG17902 and CG32116 merged as CG33264 in release 3.2 of the genome annotation. (FlyBase Genome Annotators, 2004)
Comments About Role
Comments About Molecular Function
Other Comments
	New annotation (CG32116) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206348 NM_206347 RefSeq (Proteins) • NP_996070 NP_996069 DDBJ / EMBL / GenBank • AE003539 AAF49864 AAN11842 BD268287 BD268288 UniProtKB/Swiss-Prot • P82985 Q9VU27
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Olfactory receptor, Drosophila (IPR004117)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 77813 DEDB - Drosophila exon database: splicing graphs • 4244 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0041622 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041622 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041622
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	69a (Vogt et al., 2002) 69b (Vogt et al., 2002) 69F.1 (Warr and Vosshall, 2000.5.19) CG17902   CG32116   CG33264   DOR82 (Warr and Vosshall, 2000.5.19) DOR83 (Warr and Vosshall, 2000.5.19) Or69a (Reiter et al., 2007) Or69aA (Robertson et al., 2003) Or69aB (Robertson et al., 2003) Or69b (Otaki and Yamamoto, 2003, Warr et al., 2000, Vosshall et al., 2000, Carlson et al., 2002)
Name Synonym	Odorant receptor 69a (Warr and Vosshall, 2000.5.19) Odorant receptor 69b
Secondary FlyBase IDs
	FBgn0053264 FBgn0036326 FBgn0052116
References ( 20 )
Research paper	Reiter et al., 2007, Fly 1(3): 164--171 Accentuate the Negative. [FBrf0200136] Couto et al., 2005, Curr. Biol. 15(17): 1535--1547 Molecular, anatomical, and functional organization of the Drosophila olfactory system. [FBrf0187305] Fishilevich and Vosshall, 2005, Curr. Biol. 15(17): 1548--1553 Genetic and functional subdivision of the Drosophila antennal lobe. [FBrf0187306] Robertson et al., 2003, Proc. Natl. Acad. Sci. USA 100(Supplement 2): 14537--14542 Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. [FBrf0168007] Vogt et al., 2002, J. exp. Biol. 205(6): 719--744 A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera). [FBrf0147124] Vosshall et al., 2000, Cell 102(2): 147--159 An olfactory sensory map in the fly brain. [FBrf0130146]
Review	Otaki and Yamamoto, 2003, J. Theor. Biol. 223(1): 27--37 Length analyses of Drosophila odorant receptors. [FBrf0160830]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Robertson, 2005.7.22, Dpse Ors and Grs. Dpse Ors and Grs. [FBrf0188558] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Robertson, 2003.6.24, FlyBase error report for Gr22bP on Tue Jun 24 18:27:17 2003. FlyBase error report for Gr22bP on Tue Jun 24 18:27:17 2003. [FBrf0161501] Robertson, 2001.5.16, FlyBase error report on Wed Mar 16 12:13:50 2001. FlyBase error report on Wed Mar 16 12:13:50 2001. [FBrf0136024] Warr and Vosshall, 2000.5.19, Odorant receptors. Odorant receptors. [FBrf0128191]
FlyBase analysis	FlyBase Genome Annotators, 2004, Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. [FBrf0166453] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Letter	Warr et al., 2000, Cell 102(2): 145--146 A unified nomenclature system for the Drosophila odorant receptors. [FBrf0130157]
Patent	Carlson et al., 2002, Japanese Patent 2002-534971: [Novel odorant receptors in drosophila.] [FBrf0198932]
Protein sequence record	Swiss-Prot Project Members, 2000.5.1, UniProtKB: Q9VU27 PUTATIVE ODORANT RECEPTOR 69B. [FBrf0132013] Swiss-Prot Project Members, 2000.10.1, UniProtKB: P82985 PUTATIVE ODORANT RECEPTOR 69A. [FBrf0136628]