A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Sc2

General Information
SymbolDmel\Sc2SpeciesD. melanogaster
NameSc2Annotation symbolCG10849
Feature typeprotein_coding_geneFlyBase IDFBgn0035471
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map63F5-63F6Sequence location3L:3,903,511..3,905,033 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol Sc2 (CG10849, FBgn0035471). It has the cytological map location 63F5-63F6. Its sequence location is 3L:3903511..3905033. Its molecular function is described as oxidoreductase activity, acting on the CH-CH group of donors. It is involved in the biological processes: protein modification process; lipid metabolic process. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
63F5-63F6  
Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
63F5-63F6
(determined by in situ hybridisation)  
(Spradling et al., 1999)
63F5-63F6
 
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: Ubi-p63E- Sc2+ ida+ mge- Eip63F-1- Eip63F-2+
(Vaskova et al., 2000)
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Sc2 for information on other features
detailed view FBtr0073179 FBtr0073178 FBtr0073177 FBtr0073159 FBtr0073161 FBtr0073160 FBpp0089269 FBpp0073034 FBpp0073035 FBpp0073017 FBpp0073018 FBpp0089265 FBti0066895 FBti0045125 FBti0047856 FBti0039434 FBti0039838 FBti0100122 FBti0035326 FBti0035965 FBti0071203 FBti0100810 FBti0071195 FBti0003919 FBti0030085
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Sc2-RA
FBtr0073159
 NM_139579
  1084
  302
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Sc2-PA  
FBpp0073017  
34.2  
302  
10.04  
  NP_647836
  AAF47807
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Ubiquitin (IPR000626)
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal (IPR001104)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003479
AAF47807
 
AI257819
 
AI403387
 
AI405453
 
AI542826
 
AI945897
 
AW944585
 
AY061621
AAL29169
 
BI166034
 
BI169934
 
BI172726
 
BI232300
 
BI233247
 
BI236470
 
BI240677
 
BI354103
 
BI367606
 
BP557379
 
BP557380
 
CO157018
 
CO194565
 
CO266438
 
CO279937
 
CO297778
 
CO297895
 
CO312385
 
CO313687
 
CO319400
 
CO320534
 
CO321346
 
CO338948
 
EC085581
 
EC088183
 
EC204423
 
EC204735
 
EC210401
 
EC222839
 
EC225257
 
EC251657
 
EC266730
 
EL882720
 
G01167
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (Oliver, 2001.8.16)
    (BDGP Project Members, 2000-)
    (BDGP Project Members, 1994-1999, Spradling et al., 1999)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0073179 FBtr0073178 FBtr0073177 FBtr0073159 FBtr0073161 FBtr0073160
        AI542826
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        lethal | recessive
        lethal | embryonic stage | recessive
        lethal | larval stage (with Df(3L)GN19)
        lethal | pupal stage | recessive
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 8 )
        For All Classical Alleles Show

        Allele of Sc2ClassMutagenStocksKnown lesion
        Sc2056341 Yes
        Sc210
          		1 Yes
          Sc21hypomorph2 --
          Sc2A4
            		1 --
            Sc2CB046380 Yes
            Sc2E15
              		0 --
              Sc2F9
                		1 --
                Sc2unspecified
                  		0 --
                  hide Alleles Carried on Transgenic Constructs ( 1 )
                  For All Alleles Carried on Transgenic Constructs Show

                  Allele of Sc2ClassMutagenStocksKnown lesion
                  Sc2GD22861 Yes
                  hide Aneuploid Aberrations
                  Useful deficiency
                   
                  Useful duplication
                   
                  Disrupted in
                  (Spradling et al., 1999)
                  (Christensen et al., 2007.10.29)
                  (Ryder, 2004.4.26)
                  (Vaskova et al., 2000, Harrison et al., 1995)
                  (Harrison et al., 1995)
                  (Wohlwill and Bonner, 1991, BDGP Project Members, 1994-1999)
                  (Wohlwill and Bonner, 1991)
                  (Wohlwill and Bonner, 1991, Harrison et al., 1995)
                  Not disrupted in
                  (Harrison et al., 1995)
                  (Spradling et al., 1999, BDGP Project Members, 1994-1999, Spradling et al., 1995)
                  (Wohlwill and Bonner, 1991)
                  (Wohlwill and Bonner, 1991)
                  (Wohlwill and Bonner, 1991)
                  (Harrison et al., 1995)
                  hide Transgenic Constructs & Insertions
                  Transgenic Constructs
                  Type of construct
                  Name
                  Expression data
                  UAS construct
                  P{GD2286}
                  NA
                  Insertions
                  Type of insertions
                  Name
                  Expression data
                  miscellaneous insertions
                  P{PTT-GB}Sc2CB04638
                  NA
                  P{UASp-YFP.Rab8.Q67L}Sc210
                  NA
                  insertion of enhancer trap
                  P{PZ}Sc205634
                  Yes
                  hide Related Comments
                  Please look at the allele reports for the complete phenotype data
                  Discussed during genetic analysis of the Ras64B-Rop region.
                  (Harrison et al., 1995)
                  hide Gene Ontology: Function, Process & Cellular Component ( 5 )
                  hide Molecular Function
                  CV term
                  Evidence
                  References
                  oxidoreductase activity, acting on the CH-CH group of donors
                  inferred from electronic annotation with InterPro:IPR001104
                  (FlyBase Curators et al., 2004-)
                  hide Biological Process
                  CV term
                  Evidence
                  References
                  lipid metabolic process
                  inferred from electronic annotation with InterPro:IPR001104
                  (FlyBase Curators et al., 2004-)
                  protein modification process
                  inferred from electronic annotation with InterPro:IPR000626
                  (FlyBase Curators et al., 2004-)
                  hide Cellular Component
                  CV term
                  Evidence
                  References
                  cytoplasm
                  inferred from electronic annotation with InterPro:IPR001104
                  (FlyBase Curators et al., 2004-)
                  integral to membrane
                  inferred from electronic annotation with InterPro:IPR001104
                  (FlyBase Curators et al., 2004-)
                  hide Sequence Ontology: Class of Gene
                  protein_coding_gene
                   
                  nuclear_gene
                   
                  hide Interactions & Pathways
                  hide Summary of Genetic Interactions
                  Interacts with
                  Please look at the allele data for full details of the genetic interactions
                  Sc2 allele
                  Gene
                  References
                  Sc205634
                  Kr
                  (Carrera et al., 1998, Abrell et al., 2000)
                  hide External Data
                  Linkouts
                  BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
                  •
                  hide Orthologs
                  Genome-wide drosophilid orthologs
                  Curated drosophilid orthologs
                   
                  Linkouts
                  InParanoid orthologs - Eukaryotic orthologs
                  •
                  hide Functional Complementation between Species
                  hide Inter-Species Misexpression Data
                  Produces phenotype in
                  Produces NO phenotype in
                  hide Stocks & Reagents
                  hide Stocks Listed in FlyBase ( 7 )
                  VDRC
                  v7480
                  w1118; P{GD2286}v7480
                  Kyoto
                  107343
                  Sc21/TM6B, Tb1
                  Bloomington
                  2459
                  Sc21/TM6B, Tb1
                  5160
                  bw1; Sc2A4 st1/TM6B, Tb+
                  5161
                  bw1; Sc2F9 st1/TM6B, Tb+
                  11666
                  P{PZ}Sc205634 ry506/TM3, ryRK Sb1 Ser1
                  23301
                  y1 w*; P{UASp-YFP.Rab8.Q67L}Sc210/TM3, P{Thb8-lacZ}WD1, Sb1 Ser1
                  hide Genomic Clones ( 1 )
                  hide cDNA Clones ( 27 )
                  Please Note
                  This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
                  cDNA Clones, Fully Sequenced
                  BDGP DGC clones
                  Other clones
                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  hide RNAi & Array Information
                  Affy Oligo
                  Linkouts
                  DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
                  •
                  GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
                  •
                  hide Antibody Information
                  hide Other Information
                  hide Discoverer
                  hide Etymology
                  hide Identification
                  hide Position Effect Variegation Data
                  hide Relationship to Other Genes
                  Source for database identity of
                  Source for identity of: Sc2 CG10849 Source for identity of: Sc2 l(3)63Eb The insertion in the "l(3)05634" line is within the @Sc2@ gene, rather than affecting @Ubi-p63E@ as stated in FBrf0111489.
                  (Vaskova et al., 2000)
                  Source for database merge of
                  Additional comments
                  The insertion in the "l(3)05634" line is stated to affect Ubi-p63E in this paper. A subsequent publication suggests that this is incorrect and the insertion is in fact in Sc2 (see FBrf0130136).
                  (Spradling et al., 1999)
                  hide Comments About Role
                  hide Comments About Molecular Function
                  hide Other Comments
                  hide External Crossreferences & Linkouts
                  Sequence Crossreferences
                  RefSeq (Transcripts)
                  •
                  RefSeq (Proteins)
                  •
                  DDBJ / EMBL / GenBank
                  •
                  UniProtKB/TrEMBL
                  •
                  Other Crossreferences
                  InterPro domains - A database of protein families, domains, and functional sites
                  •
                  Ubiquitin (IPR000626)
                  3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal (IPR001104)
                  Linkouts
                  BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
                  •
                  DEDB - Drosophila exon database: splicing graphs
                  •
                  DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
                  •
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  •
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  •
                  FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
                  •
                  GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
                  •
                  GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
                  •
                  InParanoid orthologs - Eukaryotic orthologs
                  •
                  PANTHER - Protein classification by function, families, and pathways
                  •
                  University of Chicago Dev. Expression
                  •
                  hide Synonyms & Secondary IDs ( 8 )
                  Reported As