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Gene Dmel\CG3511

General Information
Symbol	Dmel\CG3511	Species	D. melanogaster
Name	CG3511	Annotation symbol	CG3511
Feature type	protein_coding_gene	FlyBase ID	FBgn0035027
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60D5-60D5	Sequence location	2R:20,459,192..20,462,027 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol CG3511 (FBgn0035027). It has the cytological map location 60D5. Its sequence location is 2R:20459192..20462027. Its molecular function is described as peptidyl-prolyl cis-trans isomerase activity. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60D5-60D5   Limits computationally determined from genome sequence between P{lacW}Nurf-38k16102 and P{lacW}Mmp1k04809
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\CG3511 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG3511-RA FBtr0072309  NM_138091   2161   637
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein CG3511-PA   FBpp0072216   71.8   637   7.14     NP_611935   AAF47231
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0035027
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (IPR002130) WD40 repeat-like (IPR011046) WD40/YVTN repeat-like (IPR015943) Cyclophilin-like (IPR015891)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441456   AA567952   AA735418   AA941931   AA978752   AE003464 AAF47231   AI293455   AI296928   AI511824   AI512237   AI516373   AI519966   AW943483   AY051909 AAK93333   BI172750   BI212707   BI214572   BI235920   BI376117   BI482101   BI577932   BI577945   BI578528   BI612978   BI614942   BI620658   BI624383   CO268978   CO275047   CO342731   EC059622   EC225845   EC247987   EC258396
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q960Q8
Maps to
Does NOT map to
Identified with	LD39850 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References deletion CG3511[1]-3 2R:20,459,934..20,459,934 comment=Deletion of a single C residue leads to a frameshift and truncation of the CDS after 24 novel amino acids. Two missense mutations are also observed in CG3511[1]. evidence=experimental reported_pr_change=N133E|CG3511-PA (Parks, 2004.5.6, Edgar et al., 2005) point mutation CG3511[1]-1 2R:20,459,931..20,459,931 comment=One of two missense mutations observed in CG3511[1]. In addition, a single base is deleted leading to a frameshift. evidence=experimental na_change=C20459931T pr_change=T132T|CG3511-PA reported_na_change=C569T reported_pr_change=T133T (Parks, 2004.5.6, Edgar et al., 2005) point mutation CG3511[1]-2 2R:20,459,932..20,459,932 comment=One of two missense mutations observed in CG3511[1]. In addition, a single base is deleted in same codon leading to a frameshift. evidence=experimental na_change=A20459932G pr_change=N133D|CG3511-PA reported_na_change=A570G reported_pr_change=N133E (Parks, 2004.5.6, Edgar et al., 2005)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 1696
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI512789 AI519966 AA941931
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035027 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0035027 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0035027
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | recessive CG35111 Other Phenotypes Allele large body | larval stage (with CG35112) CG35111 large body | larval stage (with CG35111) CG35112 large body | larval stage | recessive CG35111 CG35112 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG3511 Class Mutagen Stocks Known lesion CG35111 ethyl methanesulfonate 1 -- CG35112 γ ray 1 Yes CG3511EY22555 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG3511 Class Mutagen Stocks Known lesion CG3511GD11160 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes
Aneuploid Aberrations
Useful deficiency	Df(2R)Px2
Useful duplication	Dp(2;3)Me3
Disrupted in	Df(2R)Exel8091 (Edgar et al., 2005) Df(2R)Px2 (Edgar et al., 2005)
Not disrupted in	Df(2L)Exel9043 (Edgar et al., 2005) Df(2R)ES1 (Edgar et al., 2005) Df(2R)Exel6080 (Edgar et al., 2005) Df(2R)Exel6082 (Edgar et al., 2005) Df(2R)Exel6278 (Edgar et al., 2005) Df(2R)Exel6281 (Edgar et al., 2005) Df(2R)Exel7180 (Edgar et al., 2005) Df(2R)Exel7182 (Edgar et al., 2005) Df(2R)Exel7184 (Edgar et al., 2005) Df(2R)Exel7185 (Edgar et al., 2005) Df(2R)Exel7186 (Edgar et al., 2005) Df(2R)Exel9024 (Edgar et al., 2005) Df(2R)M60E (Edgar et al., 2005) Df(2R)bw-S46 (Edgar et al., 2005) Df(2R)bwVDe2LPxKR (Edgar et al., 2005) Df(2R)gsb (Edgar et al., 2005) Df(2R)or-BR6 (Edgar et al., 2005) In(2LR)Px4 (Edgar et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11160} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG3511EY22555 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 1 )
Molecular Function
CV term Evidence References
peptidyl-prolyl cis-trans isomerase activity inferred from sequence or structural similarity with EMBL:AL023704; protein_id:CAA19257.1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG3511 allele Gene References CG35111 Rbf (Edgar et al., 2005) CG35112 Rbf (Edgar et al., 2005)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 63498
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13630 Dere\GG22984 Dgri\GH20004 Dmoj\GI19185 Dper\GL10223 Dpse\GA17492 Dsec\GM11877 Dsim\GD11875 Dvir\GJ20247 Dwil\GK12669 Dyak\GE14421
Curated drosophilid orthologs	Dpse\GA17492
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000014257 Anopheles gambiae (Ensembl) ENSBTAP00000012520 Bos taurus (Ensembl) ENSCAFP00000011028 Canis familiaris (Ensembl) ENSCINP00000014201 Ciona intestinalis (Ensembl) NEWSINFRUP00000136540 Takifugu rubripes (Ensembl) ENSGALP00000023753 Gallus gallus (Ensembl) ENSP00000261308 Homo sapiens (Ensembl) ENSMMUP00000021698 Macaca mulatta (Ensembl) ENSMODP00000024511 Monodelphis domestica (Ensembl) ENSPTRP00000028983 Pan troglodytes (Ensembl) ENSRNOP00000016863 Rattus norvegicus (Ensembl) GSTENP00025246001 Tetraodon nigroviridis (Ensembl) ENSXETP00000000964 Xenopus tropicalis (Ensembl) Q6ZJ09 Oryza sativa (Gramene) AT3G44600.1 Arabidopsis thaliana (Arabidopsis) WBGene00029907 Caenorhabditis briggsae (Wormbase) WBGene00000891 Caenorhabditis elegans (Wormbase) DDB0216615 Dictyostelium discoideum (Dictybase) MGI:2443069 Mus musculus (Informatics) NP_415058.1 Escherichia coliK12 (NCBI) NP_417822.1 Escherichia coliK12 (NCBI) SPCC553.04 Schizosaccharomyces pombe (Sanger)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
VDRC	v21733 w1118 P{GD11160}v21733 v21735 w1118; P{GD11160}v21735
Bloomington	8197 P{neoFRT}42D c1 px1 CG35111/CyO 8198 P{neoFRT}42D c1 px1 CG35112/CyO 22568 y1 w67c23; P{EPgy2}CG3511EY22555
Genomic Clones ( 2 )
	BACR11C07 BACR03I24
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD39850
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE72409 HL02040 RE20519 LD42226 RH63934 RE71722 LD32907 RE71706 RH44443 RE17850 LD43356 RE15421 RE64752 RH42016 LP06607 LD27277 LD16401 LD21274 RE31877 LD44011 RH51851 LP11051 RE64049
Other clones	EK093229 EK116304 EP15420
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0035027 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0035027
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138091 RefSeq (Proteins) • NP_611935 DDBJ / EMBL / GenBank • AE003464 AAF47231 AI519966 AW943483 AY051909 AAK93333 UniProtKB/TrEMBL • Q960Q8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (IPR002130) WD40 repeat-like (IPR011046) WD40/YVTN repeat-like (IPR015943) Cyclophilin-like (IPR015891)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 63498 DEDB - Drosophila exon database: splicing graphs • 1696 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0035027 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035027 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0035027 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035027 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0035027 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0035027 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000014257 Anopheles gambiae (Ensembl) ENSBTAP00000012520 Bos taurus (Ensembl) ENSCAFP00000011028 Canis familiaris (Ensembl) ENSCINP00000014201 Ciona intestinalis (Ensembl) NEWSINFRUP00000136540 Takifugu rubripes (Ensembl) ENSGALP00000023753 Gallus gallus (Ensembl) ENSP00000261308 Homo sapiens (Ensembl) ENSMMUP00000021698 Macaca mulatta (Ensembl) ENSMODP00000024511 Monodelphis domestica (Ensembl) ENSPTRP00000028983 Pan troglodytes (Ensembl) ENSRNOP00000016863 Rattus norvegicus (Ensembl) GSTENP00025246001 Tetraodon nigroviridis (Ensembl) ENSXETP00000000964 Xenopus tropicalis (Ensembl) Q6ZJ09 Oryza sativa (Gramene) AT3G44600.1 Arabidopsis thaliana (Arabidopsis) WBGene00029907 Caenorhabditis briggsae (Wormbase) WBGene00000891 Caenorhabditis elegans (Wormbase) DDB0216615 Dictyostelium discoideum (Dictybase) MGI:2443069 Mus musculus (Informatics) NP_415058.1 Escherichia coliK12 (NCBI) NP_417822.1 Escherichia coliK12 (NCBI) SPCC553.04 Schizosaccharomyces pombe (Sanger) PANTHER - Protein classification by function, families, and pathways • FBgn0035027 University of Chicago Dev. Expression • FBgn0035027
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG3511
Name Synonym	CG3511
Secondary FlyBase IDs
References ( 11 )
Research paper	Edgar et al., 2005, Genetics 170(1): 161--171 Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene. [FBrf0187639] Orian et al., 2003, Genes Dev. 17(9): 1101--1114 Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. [FBrf0158942]
Supplementary material	Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bellen, 2006.8.3, MBBatch686_2.xml MBBatch686_2.xml [FBrf0191805] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Parks, 2004.5.6, CG3511<up>1</up> and CG3511<up>2</up>. CG3511<up>1</up> and CG3511<up>2</up>. [FBrf0178833]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Beasley, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126653]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]