A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\eIF6

General Information
SymbolDmel\eIF6SpeciesD. melanogaster
NameeIF6Annotation symbolCG17611
Feature typeprotein_coding_geneFlyBase IDFBgn0034915
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map60A3-60A3Sequence location2R:19,736,769..19,737,822 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol eIF6 (CG17611, FBgn0034915). It has the cytological map location 60A3. Its sequence location is 2R:19736769..19737822. Its molecular function is described as: translation initiation factor activity; ribosome binding. It is involved in the biological processes: translational initiation; translation; mature ribosome assembly. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
60A3-60A3  
Limits computationally determined from genome sequence between P{EP}eglEP938 and P{lacW}eIF6k13214  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
60A2-60A3
 
(Kaiser, 1996.4.19)
60A3-60A4
(determined by in situ hybridisation)  
(Spradling et al., 1999)
60A3-60A4
 
(Beaton, 1997.12.27)
60A3-60A4
 
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\eIF6 for information on other features
detailed view FBtr0072235 FBtr0072234 FBtr0072127 FBpp0072144 FBpp0072143 FBpp0072036 FBti0006448 FBti0010875 FBti0039809 FBti0100918 FBti0034576 FBti0023367 FBti0030038
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
eIF6-RA
FBtr0072235
 NM_145105
  1054
  245
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
eIF6-PA  
FBpp0072144  
26.5  
245  
4.34  
  NP_659573
  AAF47074
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Translation initiation factor IF6 (IPR002769)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003462
AAF47074
 
AI109537
 
AQ026049
 
AW941716
 
AX260191
 
AX260193
 
AY094688
AAM11041
 
BE979055
 
BF486927
 
BI142033
 
BI172738
 
BI231576
 
BI605824
 
BI633807
 
CO305127
 
CO337806
 
EC244695
 
EC265243
 
X97641
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (Spradling et al., 1999, BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0072235 FBtr0072234 FBtr0072127
        AI109537
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for eIF6
        FlyExpress - Embryonic expression images (BDGP data)
        •
        Show all FlyExpress processed images for eIF6
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        lethal | recessive
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 2 )
        For All Classical Alleles Show

        Allele of eIF6ClassMutagenStocksKnown lesion
        eIF65E240 --
        eIF6k132142 Yes
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of eIF6ClassMutagenStocksKnown lesion
        eIF6GD94250 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
         
        Disrupted in
        (Spradling et al., 1999, BDGP Project Members, 1994-1999)
        (Spradling et al., 1999, Beaton, 1997.12.27)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD9425}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        insertion of enhancer trap
        P{lacW}eIF6k13214
        No
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 6 )
        hide Molecular Function
        CV term
        Evidence
        References
        ribosome binding
        inferred from electronic annotation with InterPro:IPR002769
        (FlyBase Curators et al., 2004-)
        translation initiation factor activity
        inferred from sequence or structural similarity
        (Lasko, 2000)
        inferred from sequence or structural similarity with EMBL:AF022229; protein_id:AAB97735
        (Mi et al., 2001.12.13)
        hide Biological Process
        CV term
        Evidence
        References
        mature ribosome assembly
        inferred from electronic annotation with InterPro:IPR002769
        (FlyBase Curators et al., 2004-)
        translation
        non-traceable author statement
        (Swiss-Prot Project Members, 1998.2.1)
        translational initiation
        inferred from sequence or structural similarity
        (Lasko, 2000)
        hide Cellular Component
        CV term
        Evidence
        References
        cytosol
        inferred from sequence or structural similarity
        (Lasko, 2000)
        non-traceable author statement
        (Swiss-Prot Project Members, 1998.2.1)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        eIF6 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 2 )
        Kyoto
        102858
        Df(1)w67c23, y1 ; P{lacW}eIF6k13214 / CyO
        Bloomington
        12197
        y1 w67c23; P{lacW}eIF6k13214 ytrk13214/CyO
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 10 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: eIF6 CG17611
        (Lasko, 2000)
        Source for database merge of
        Source for merge of: eIF6 l(2)k13214 Source for merge of eIF6 l(2)k13214 was a shared cDNA (date:030206). Source for merge of: eIF6 anon-WO0172774.153 anon-WO0172774.155 Source for merge of eIF6 anon-WO0172774.153 anon-WO0172774.155 was sequence comparison (date:051113).
        (FlyBase, 1996-)
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/Swiss-Prot
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Translation initiation factor IF6 (IPR002769)
        Linkouts
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for eIF6
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyExpress - Embryonic expression images (BDGP data)
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 7 )
        Reported As
        Symbol Synonym
        anon-WO0172774.153
         
        anon-WO0172774.155
         
        CG17611
        (McKearin, 2000.8.3, Lasko, 2000, )
        eif6
        (Orian et al., 2003)
        eIF6
        (Janody and Treisman, 2006, Eulalio et al., 2007, Akdemir et al., 2007)
        l(2)k13214
        (Spradling et al., 1999, Beaton, 1997.12.27, )
        unnamed
        (Kaiser, 1996.4.19)
        Name Synonym
        eIF6
         
        Secondary FlyBase IDs
        • FBgn0021890
        • FBgn0046444
        • FBgn0046445
        hide References ( 21 )
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        hide Recent research papers ( 3 )
        Akdemir et al., 2007, Oncogene 26(36): 5184--5193
        p53 directs focused genomic responses in Drosophila. [FBrf0202061]
        Eulalio et al., 2007, Genes Dev. 21(20): 2558--2570
        Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. [FBrf0201064]
        Janody and Treisman, 2006, Development 133(17): 3349--3357
        Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium. [FBrf0193788]
        Show all research papers ...