A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\comr

General Information
SymbolDmel\comrSpeciesD. melanogaster
Namecookie monsterAnnotation symbolCG13493
Feature typeprotein_coding_geneFlyBase IDFBgn0034667
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2RRecombination map2-
Cytogenetic map 58A3-58A3 Sequence location2R:17,752,372..17,754,364 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene cookie monster is referred to in FlyBase by the symbol comr (CG13493, FBgn0034667). It has the cytological map location 58A3. Its sequence location is 2R:17752372..17754364. Its molecular function is described as transcription activator activity. It is involved in the biological processes: positive regulation of transcription from RNA polymerase II promoter; spermatogenesis. 2 alleles are reported. The phenotypes of these alleles are annotated with: testis; meiotic cell cycle; spermatid. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
58A3-58A3  
Limits computationally determined from genome sequence between P{EP}Tim10EP541&P{lacW}l(2)k09617k09617 and P{PZ}l(2)0783707837  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
2-
(White-Cooper, 1999.3.3)
Left of (cM)
(White-Cooper, 1999.3.3)
Right of (cM)
(White-Cooper, 1999.3.3)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\comr for information on other features
detailed view FBtr0071735 FBpp0071651 FBti0052446 FBti0045245 FBti0047174 FBti0040288
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
comr-RA
FBtr0071735
 NM_137773
  1993
  600
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
comr-PA  
FBpp0071651  
68.4  
600  
4.88  
  NP_611617
  AAF46771
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Winged helix repressor DNA-binding (IPR011991)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003455
AAF46771
 
AY119451
AAM50105
 
BF491035
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        testis
        meiotic cell cycle
        spermatid
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of comrClassMutagenStocksKnown lesion
        comrz1340
          		0 --
          hide Alleles Carried on Transgenic Constructs ( 1 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of comrClassMutagenStocksKnown lesion
          comrGD80391 Yes
          hide Aneuploid Aberrations
          Useful deficiency
           
           
           
          Useful duplication
           
          Disrupted in
          (Jiang and White-Cooper, 2003, Jiang and White-Cooper, 2003)
          (Ryder, 2004.4.26)
          (Ryder, 2004.4.26)
          (White-Cooper, 1999.3.3)
          (White-Cooper, 1999.3.3, Jiang and White-Cooper, 2003, Jiang and White-Cooper, 2003)
          (Jiang and White-Cooper, 2003, Jiang and White-Cooper, 2003)
          Not disrupted in
          (White-Cooper, 1999.3.3)
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          P{GD8039}
          NA
          Insertions
          Type of insertions
          Name
          Expression data
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          hide Gene Ontology: Function, Process & Cellular Component ( 5 )
          hide Molecular Function
          CV term
          Evidence
          References
          transcription activator activity
          inferred from mutant phenotype
          (Jiang and White-Cooper, 2003)
          hide Biological Process
          CV term
          Evidence
          References
          positive regulation of transcription from RNA polymerase II promoter
          inferred from mutant phenotype
          (Jiang and White-Cooper, 2003)
          spermatogenesis
          inferred from mutant phenotype
          (Jiang and White-Cooper, 2003)
          hide Cellular Component
          CV term
          Evidence
          References
          chromatin
          non-traceable author statement
          (White-Cooper et al., 2003)
          nucleus
          inferred from direct assay
          (Jiang and White-Cooper, 2003)
          hide Sequence Ontology: Class of Gene
          protein_coding_gene
           
          nuclear_gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          comr allele
          Gene
          References
          unspecified
          aly
          (Jiang and White-Cooper, 2003)
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
           
          Linkouts
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 1 )
          VDRC
          v17218
          w1118; P{GD8039}v17218
          hide Genomic Clones ( 1 )
          hide cDNA Clones ( 1 )
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          hide Antibody Information
          polyclonal antibody
          (Perezgasga et al., 2004)
          hide Other Information
          hide Discoverer
          hide Etymology
          Etymology: Named "cookie monster" because spermatid cells look like a 'whole bunch of cookie monster eyes'.
          (Jiang and White-Cooper, 2003)
          hide Identification
          hide Position Effect Variegation Data
          hide Relationship to Other Genes
          Source for database identity of
          Source for identity of: comr CG13493
          (White-Cooper, 2003.2.10)
          Source for database merge of
          Source for merge of: comr zab
          (White-Cooper, 2005.9.6)
          Additional comments
          hide Comments About Role
          comr and aly appear to have a mutually dependent role in transcriptional activation during spermatogenesis.
          (Jiang and White-Cooper, 2003)
          hide Comments About Molecular Function
          comr encodes a novel acidic protein which localises to chromatin in wild type primary spermatocytes.
          (White-Cooper et al., 2003)
          achi, vis, aly and comr proteins may exist in a complex.
          (Wang and Mann, 2003)
          hide Other Comments
          aly-like meiotic arrest gene.
          (White-Cooper and Fuller, 1999)
          hide External Crossreferences & Linkouts
          Sequence Crossreferences
          RefSeq (Transcripts)
          •
          RefSeq (Proteins)
          •
          DDBJ / EMBL / GenBank
          •
          UniProtKB/TrEMBL
          •
          Other Crossreferences
          InterPro domains - A database of protein families, domains, and functional sites
          •
          Winged helix repressor DNA-binding (IPR011991)
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          DEDB - Drosophila exon database: splicing graphs
          •
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          •
          FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
          •
          GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          PANTHER - Protein classification by function, families, and pathways
          •
          hide Synonyms & Secondary IDs ( 7 )
          Reported As
          Symbol Synonym
          CG13493
          (Jiang and White-Cooper, 2003, Giot et al., 2003, Beall et al., 2007)
          comr
          (Bausek et al., 2007, Jiang et al., 2007, Benson et al., 2007, Jiang et al., 2007, Zhang et al., 2007)
          Comr
          (Doggett et al., 2007, Beall et al., 2007)
          Z2-1340
           
          zab
          (White-Cooper, 1999.3.3, )
          Name Synonym
          cookie monster
          (White-Cooper et al., 2003)
          zuker-aly-like b
          (White-Cooper, 1999.3.3)
          Secondary FlyBase IDs
          • FBgn0026154
          hide References ( 27 )
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          hide Recent research papers ( 2 )
          Beall et al., 2007, Genes Dev. 21(8): 904--919
          Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. [FBrf0200827]
          Jiang et al., 2007, Development Suppl.:
          Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with Always early. [FBrf0194011]
          Show all research papers ...