Gene Dmel\Nup75

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General Information

Symbol

Dmel\Nup75

Species

D. melanogaster

Name

CG5733

Annotation symbol

CG5733

Feature type

protein_coding_gene

FlyBase ID

FBgn0034310

Created / Updated

2003-12-01/2007-06-27

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

55B10-55B11

Sequence location

2R:14,052,193..14,054,634 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene CG5733 is referred to in FlyBase by the symbol Nup75 (CG5733, FBgn0034310). It has the cytological map location 55B10-55B11. Its sequence location is 2R:14052193..14054634. Its molecular function is unknown. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55B10-55B11

Limits computationally determined from genome sequence between P{PZ}Hsf⁰³⁰⁹¹&P{EP}Dgp-1^EP731 and P{PZ}sbb⁰⁴⁵²⁵&P{EP}EP1081^EP1081

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Nup75 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Nup75-RA

FBtr0086775

NM_137456

2141

668

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Nup75-PA

FBpp0085954

76.9

668

5.93

NP_611300

AAF57735

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0034310

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nucleoporin, Nup85-like (IPR011502)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

LD29726

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

12007

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AA949731

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0034310

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0034310

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0034310

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Nup75	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Nup75	Class	Mutagen	Stocks	Known lesion
Nup75^GD11751		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)Pcl11B

Useful duplication

Dp(2;Y)53D;57C

Disrupted in

Df(2R)Exel7152

(Ryder, 2004.4.26)

Df(2R)Exel7153

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD11751}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}KG09695

insertion of enhancer trap

P{lacW}l(2)SH0499^SH0499

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 0 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Nup75 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62759

Drosophila PIMRider - The Drosophila Protein Interaction map

•

521442

Orthologs

Genome-wide drosophilid orthologs

Dana\GF12278

Dere\GG20987

Dgri\GH20846

Dmoj\GI20950

Dper\GL10512

Dpse\GA19092

Dsec\GM19922

Dsim\Nup75

Dvir\GJ20672

Dwil\GK20632

Dyak\GE13930

Curated drosophilid orthologs

Dpse\GA19092

Dsim\Nup75

(Presgraves and Stephan, 2006.10.11)

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000008989
Anopheles gambiae (Ensembl)
ENSBTAP00000021465
Bos taurus (Ensembl)
ENSCAFP00000007050
Canis familiaris (Ensembl)
ENSCINP00000019434
Ciona intestinalis (Ensembl)
NEWSINFRUP00000153238
Takifugu rubripes (Ensembl)
ENSGALP00000012932
Gallus gallus (Ensembl)
ENSP00000245544
Homo sapiens (Ensembl)
ENSMMUP00000023675
Macaca mulatta (Ensembl)
ENSMODP00000008983
Monodelphis domestica (Ensembl)
ENSPTRP00000016374
Pan troglodytes (Ensembl)
ENSRNOP00000005035
Rattus norvegicus (Ensembl)
GSTENP00022449001
Tetraodon nigroviridis (Ensembl)
Q5JLX7
Oryza sativa (Gramene)
Q8LIZ0
Oryza sativa (Gramene)
AT4G32910.1
Arabidopsis thaliana (Arabidopsis)
WBGene00026829
Caenorhabditis briggsae (Wormbase)
WBGene00003788
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-040801-155
Danio rerio (Zfin)
ZDB-GENE-040801-145
Danio rerio (Zfin)
DDB0218715
Dictyostelium discoideum (Dictybase)
MGI:3046173
Mus musculus (Informatics)
SPBC17G9.04c
Schizosaccharomyces pombe (Sanger)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

VDRC

v27495

w¹¹¹⁸ P{GD11751}v27495

Szeged

P{lacW}l(2)SH0499^SH0499

Bloomington

14790

y¹; P{SUPor-P}KG09695/CyO; ry⁵⁰⁶

Genomic Clones ( 2 )

cDNA Clones ( 10 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD29726

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0034310

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0034310

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_137456

RefSeq (Proteins)

•

NP_611300

DDBJ / EMBL / GenBank

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nucleoporin, Nup85-like (IPR011502)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62759

DEDB - Drosophila exon database: splicing graphs

•

12007

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0034310

Drosophila PIMRider - The Drosophila Protein Interaction map

•

521442

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0034310

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0034310

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0034310

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0034310

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0034310

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000008989
Anopheles gambiae (Ensembl)
ENSBTAP00000021465
Bos taurus (Ensembl)
ENSCAFP00000007050
Canis familiaris (Ensembl)
ENSCINP00000019434
Ciona intestinalis (Ensembl)
NEWSINFRUP00000153238
Takifugu rubripes (Ensembl)
ENSGALP00000012932
Gallus gallus (Ensembl)
ENSP00000245544
Homo sapiens (Ensembl)
ENSMMUP00000023675
Macaca mulatta (Ensembl)
ENSMODP00000008983
Monodelphis domestica (Ensembl)
ENSPTRP00000016374
Pan troglodytes (Ensembl)
ENSRNOP00000005035
Rattus norvegicus (Ensembl)
GSTENP00022449001
Tetraodon nigroviridis (Ensembl)
Q5JLX7
Oryza sativa (Gramene)
Q8LIZ0
Oryza sativa (Gramene)
AT4G32910.1
Arabidopsis thaliana (Arabidopsis)
WBGene00026829
Caenorhabditis briggsae (Wormbase)
WBGene00003788
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-040801-155
Danio rerio (Zfin)
ZDB-GENE-040801-145
Danio rerio (Zfin)
DDB0218715
Dictyostelium discoideum (Dictybase)
MGI:3046173
Mus musculus (Informatics)
SPBC17G9.04c
Schizosaccharomyces pombe (Sanger)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0034310

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

CG5733

Nup75

Name Synonym

CG5733

Secondary FlyBase IDs

References ( 8 )

Supplementary material

Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]
Oh et al., 2003, Genetics 163(1):: Table S1. [FBrf0157097]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]

Computer file

Gene Disruption Project members, 2001-, [title not yet available]: [title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]

DNA/RNA sequence record

Presgraves and Stephan, 2006.10.11, GenBank/EMBL/DDBJ: EF057935: Drosophila simulans strain s006 Nup75 (CG5733) gene, complete cds. [FBrf0199500]
Presgraves and Stephan, 2006.10.11, GenBank/EMBL/DDBJ: EF057923: Drosophila melanogaster strain m095 Nup75 (CG5733) gene, complete cds. [FBrf0199499]