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Gene Dmel\Dg

General Information
Symbol	Dmel\Dg	Species	D. melanogaster
Name	Dystroglycan	Annotation symbol	CG18250
Feature type	protein_coding_gene	FlyBase ID	FBgn0034072
Created / Updated	2004-08-16/2003-12-02
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52E2-52E4	Sequence location	2R:11,968,674..11,986,042 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dystroglycan is referred to in FlyBase by the symbol Dg (CG18250, FBgn0034072). It has the cytological map location 52E2-52E4. Its sequence location is 2R:11968674..11986042. Its molecular function is described as: structural constituent of muscle; protein binding; calcium ion binding. It is involved in the biological processes: cytoskeletal anchoring; establishment and/or maintenance of epithelial cell polarity; establishment and/or maintenance of polarity of follicular epithelium; oocyte anterior/posterior axis determination; establishment and/or maintenance of apical/basal cell polarity; oocyte axis determination; establishment and/or maintenance of cell polarity; growth of a germarium-derived egg chamber. 14 alleles are reported. The phenotypes of these alleles are annotated with: follicle cell; oocyte associated follicle cell; oocyte; ring canal; stage S6 oocyte. It has 3 annotated transcripts and 3 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52E2-52E4   Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52D2-52D15   (Greener, 2000.6.14)
Experimentally Determined Recombination Data
Location	2- (Takeuchi, 2001.12.19, Takeuchi, 2001.12.19, Takeuchi, 2001.12.19)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Dg for information on other features
Comments on Gene Model
	DGC clone LD04782 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dg-RA FBtr0087256  NM_079032   5718   997 Dg-RB FBtr0087257  NM_166138   5469   914 Dg-RC FBtr0087258  NM_176184   6264   1179
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Dg-PA   FBpp0086394   110.8   997   6.05     NP_523756   AAF58068 Dg-PB   FBpp0086395   102.6   914   6.32     NP_725523   AAM70943 Dg-PC   FBpp0086396   129.6   1179   4.93     NP_788364   AAO41377
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0034072
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dystroglycan-type cadherin-like (IPR006644) Dystroglycan (IPR008465) Cadherin-like (IPR015919)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201679   AA391686   AA978941   AC004248   AE003808 AAF58068   AE003808 AAM70943   AE003808 AAO41377   AF277390 AAG17399   AF461099 AAL66367   AF461100 AAL66368   AF461101 AAL66369   AI109925   AI258332   AI402170   AI531345   AI534175   AI534934   AQ254841   AW941559   AY069076 AAL39221   AY069330 AAL39475   BI352148   BI632137   BP557565   BP557566   BT025858   CK657103   CK660375   CO178479   CO179044   CO189736   CO195297   CO271305   CO275431   CO275686   CO277304   CO284930   CO285153   CO287885   CO291352   CO298721   CO310639   CO310658   CO314743   CO320699   CO321423   CO322947   CO330184   CO330324   CO330614   CO333164   CO341661   CZ479364   CZ480364   EC058329   EC060066   EC060513   EC062129   EC062901   EC068160   EC069281   EC069823   EC070472   EC073795   EC075447   EC078699   EC078939   EC085194   EC090094   EC194544   EC195442   EC195621   EC198191   EC221350   EC222748   EC227037   EC227039   EC227877   EC230202   EC232257   EC232719   EC234876   EC240061   EC241985   EC244095   EC246755   EC248008   EC248284   EL875226   EL875355   EL884080
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8STB9 Q8T0G6 Q8WR08 Q8WR09 Q9GT67 A1ZA89
Maps to	DS03910 (Deng et al., 2003)
Does NOT map to
Identified with	GH09323 (BDGP Project Members, 2000-, Takeuchi, 2001.12.19, Deng et al., 2003, Schneider, 2002.9.17) LD04782 (BDGP Project Members, 2000-, Deng et al., 2003) LD11619 (Schneider, 2002.6.17, Deng et al., 2003, Schneider, 2002.9.17) LD33152 (Takeuchi, 2001.12.19) SD06707 (Deng et al., 2003, Schneider, 2002.9.17, Schneider et al., 2006)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 12340
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI109925
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034072 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0034072 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0034072 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for Dg FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Dg Stage(s) 4-6 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele behavior defective Dgatsugari cell polarity defective | cell autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS cell polarity defective | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS cell polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS cell polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS Phenotype manifest in Allele follicle cell | somatic clone Dg248 Dg323 stage S6 oocyte | germ-line clone Dg248 oocyte | germ-line clone Dg323 ring canal | germ-line clone Dg323 oocyte associated follicle cell | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS oocyte | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PP DgC.Scer\UAS oocyte associated follicle cell | cell autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS oocyte | cell non-autonomous | somatic clone, with Scer\GAL4A62 DgC.Scer\UAS follicle cell, with Scer\GAL4αTub84B.PL DgdsRNA.Scer\UAS
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Dg Class Mutagen Stocks Known lesion Dg248 Δ2-3 0 Yes Dg323 Δ2-3 0 Yes Dg62 Δ2-3 0 Yes DgB148 1 -- DgDG30704 P-element activity 1 -- DgEP2241 P-element activity 1 -- Dgatsugari 0 -- Dge01554 piggyBac transposase 1 -- Dge02580 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dg Class Mutagen Stocks Known lesion DgB.Scer\UAS in vitro construct | regulatory fusion 0 Yes DgC.Scer\UAS in vitro construct | regulatory fusion 0 Yes DgGD3513 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes Dgcyto.Scer\UAS.T:Zzzz\FLAG in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes DgdsRNA.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes
Aneuploid Aberrations
Useful duplication	Dp(2;2)SMG45
Disrupted in	Df(2R)Exel7139 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3513} NA P{UAS-Dg-B} NA P{UAS-Dg-C} NA P{UAS-Dg.cyto} NA P{UAS-Dg.dsRNA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{5HPw+}DgB148 NA PBac{RB}Dge01554 NA PBac{RB}Dge02580 NA P{?'EP}Dg248 NA P{wHy}DgDG30704 NA insertion of enhancer trap P{lacW}l(2)SH1091SH1091 No insertion of mobile activating element P{EP}DgEP2241 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 14 )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR006644, InterPro:IPR015919 (FlyBase Curators et al., 2004-)
protein binding inferred from electronic annotation with InterPro:IPR006644, InterPro:IPR008465 (FlyBase Curators et al., 2004-)
structural constituent of muscle inferred from sequence or structural similarity with HGNC_gene:DAG1; HGNC:2666; OMIM:128239 (Greener and Roberts, 2000)
Biological Process
CV term Evidence References
cytoskeletal anchoring inferred from sequence or structural similarity (Hynes and Zhao, 2000)
establishment and/or maintenance of apical/basal cell polarity inferred from mutant phenotype (Poulton and Deng, 2006)
establishment and/or maintenance of cell polarity inferred from mutant phenotype (Yatsenko et al., 2007)
establishment and/or maintenance of epithelial cell polarity inferred from mutant phenotype (Deng et al., 2003) inferred from mutant phenotype (Yatsenko et al., 2007)
establishment and/or maintenance of polarity of follicular epithelium inferred from mutant phenotype (Deng et al., 2003)
growth of a germarium-derived egg chamber inferred from mutant phenotype (Yatsenko et al., 2007)
oocyte anterior/posterior axis determination inferred from mutant phenotype (Deng et al., 2003)
oocyte axis determination inferred from mutant phenotype (Poulton and Deng, 2006)
Cellular Component
CV term Evidence References
basal plasma membrane inferred from direct assay (Yatsenko et al., 2007)
dystroglycan complex inferred from sequence or structural similarity with HGNC_gene:DAG1; HGNC:2666; OMIM:128239 (Greener and Roberts, 2000) inferred from sequence or structural similarity (Hynes and Zhao, 2000) non-traceable author statement (Greener, 2000.6.14)
dystrophin-associated glycoprotein complex inferred from physical interaction with FLYBASE:Dys; FB:FBgn0024242 (Yatsenko et al., 2007)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dg allele Gene References unspecified Ras85D (Poulton and Deng, 2006) sli (Qian et al., 2005)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 62498 Drosophila PIMRider - The Drosophila Protein Interaction map • 521741
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13572 Dere\GG22304 Dgri\GH19821 Dmoj\GI20410 Dper\GL17285 Dpse\GA14855 Dsec\GM20094 Dsim\GD25571 Dvir\GJ20081 Dwil\GK23093