Gene Dmel\StIP

Help

Close All Open All

General Information

Symbol

Dmel\StIP

Species

D. melanogaster

Name

StIP

Annotation symbol

CG11887

Feature type

protein_coding_gene

FlyBase ID

FBgn0033540

Created / Updated

2004-08-09/2004-08-09

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

47B1-47B3

Sequence location

2R:6,533,230..6,536,144 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol StIP (CG11887, FBgn0033540). It has the cytological map location 47B1-47B3. Its sequence location is 2R:6533230..6536144. Its molecular function is described as proteasome activator activity. It is involved in the biological processes: RNA elongation from RNA polymerase II promoter; proteasome assembly. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47B1-47B3

Limits computationally determined from genome sequence between P{PZ}lola⁰⁰³⁴⁹&P{EP}lola^EP952 and P{lacW}l(2)k00909^k00909&P{EP}EP2619^EP2619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\StIP for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

StIP-RA

FBtr0088212

NM_136756

2553

794

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

StIP-PA

FBpp0087307

89.0

794

5.32

NP_610600

AAF58765

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0033540

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Regulator of chromosome condensation, RCC1 (IPR000408)

WD40 repeat (IPR001680)

WD40 repeat-like (IPR011046)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

LD47515

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

13011

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI134127
AI515618

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033540

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0033540

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0033540

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for StIP

Stage(s) 9-10

Stage(s) 11-12

Stage(s) 13-16

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of StIP	Class	Mutagen	Stocks	Known lesion
StIP^c05343		piggyBac transposase	0	--
StIP^c05390		piggyBac transposase	1	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of StIP	Class	Mutagen	Stocks	Known lesion
StIP^GD6738		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)stan2

Useful duplication

Dp(2;2)Y3b

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD6738}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}StIP^c05343

PBac{PB}StIP^c05390

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

proteasome activator activity

inferred from sequence or structural similarity with UniProtKB:Q16186

(FBrf0198885)

Biological Process

CV term

Evidence

References

RNA elongation from RNA polymerase II promoter

inferred from sequence or structural similarity with UniProtKB:Q16186

(FBrf0198885)

proteasome assembly

inferred from sequence or structural similarity with UniProtKB:Q16186

(FBrf0198885)

Cellular Component

CV term

Evidence

References

proteasome complex

inferred from sequence or structural similarity with UniProtKB:Q16186

(FBrf0198885)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

StIP allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61932

Orthologs

Genome-wide drosophilid orthologs

Dana\GF13770

Dere\GG20140

Dgri\GH21263

Dmoj\GI19340

Dper\GL17299

Dpse\GA11261

Dsec\GM21226

Dsim\GD10748

Dvir\GJ22219

Dwil\GK19482

Dyak\GE12828

Curated drosophilid orthologs

Dpse\GA11261

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000021636
Anopheles gambiae (Ensembl)
ENSBTAP00000025227
Bos taurus (Ensembl)
ENSCAFP00000026340
Canis familiaris (Ensembl)
ENSCINP00000018482
Ciona intestinalis (Ensembl)
NEWSINFRUP00000128924
Takifugu rubripes (Ensembl)
ENSGALP00000021535
Gallus gallus (Ensembl)
ENSP00000350967
Homo sapiens (Ensembl)
ENSMMUP00000024731
Macaca mulatta (Ensembl)
ENSMODP00000000519
Monodelphis domestica (Ensembl)
ENSPTRP00000040690
Pan troglodytes (Ensembl)
ENSRNOP00000020601
Rattus norvegicus (Ensembl)
GSTENP00004629001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000041054
Xenopus tropicalis (Ensembl)
Q6Z8S7
Oryza sativa (Gramene)
AT1G49540.1
Arabidopsis thaliana (Arabidopsis)
WBGene00026404
Caenorhabditis briggsae (Wormbase)
WBGene00013738
Caenorhabditis elegans (Wormbase)
DDB0231759
Dictyostelium discoideum (Dictybase)
MGI:1889642
Mus musculus (Informatics)
YGR200C
Saccharomyces cerevisiae (Yeastgenome)
SPCC895.06
Schizosaccharomyces pombe (Sanger)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

Harvard

PBac{PB}StIP^c05390

VDRC

v17560

w¹¹¹⁸; P{GD6738}v17560

v17559

w¹¹¹⁸; P{GD6738}v17559/CyO

Genomic Clones ( 2 )

cDNA Clones ( 13 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD47515

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0033540

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0033540

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: StIP CG11887

(Han and Harrison, 2006)

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_136756

RefSeq (Proteins)

•

NP_610600

DDBJ / EMBL / GenBank

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Regulator of chromosome condensation, RCC1 (IPR000408)

WD40 repeat (IPR001680)

WD40 repeat-like (IPR011046)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61932

DEDB - Drosophila exon database: splicing graphs

•

13011

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0033540

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033540

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0033540

FlyExpress - Embryonic expression images (BDGP data)

•

FBgn0033540

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0033540

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0033540

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0033540

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000021636
Anopheles gambiae (Ensembl)
ENSBTAP00000025227
Bos taurus (Ensembl)
ENSCAFP00000026340
Canis familiaris (Ensembl)
ENSCINP00000018482
Ciona intestinalis (Ensembl)
NEWSINFRUP00000128924
Takifugu rubripes (Ensembl)
ENSGALP00000021535
Gallus gallus (Ensembl)
ENSP00000350967
Homo sapiens (Ensembl)
ENSMMUP00000024731
Macaca mulatta (Ensembl)
ENSMODP00000000519
Monodelphis domestica (Ensembl)
ENSPTRP00000040690
Pan troglodytes (Ensembl)
ENSRNOP00000020601
Rattus norvegicus (Ensembl)
GSTENP00004629001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000041054
Xenopus tropicalis (Ensembl)
Q6Z8S7
Oryza sativa (Gramene)
AT1G49540.1
Arabidopsis thaliana (Arabidopsis)
WBGene00026404
Caenorhabditis briggsae (Wormbase)
WBGene00013738
Caenorhabditis elegans (Wormbase)
DDB0231759
Dictyostelium discoideum (Dictybase)
MGI:1889642
Mus musculus (Informatics)
YGR200C
Saccharomyces cerevisiae (Yeastgenome)
SPCC895.06
Schizosaccharomyces pombe (Sanger)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0033540

University of Chicago Dev. Expression

•

FBgn0033540

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

CG1187

(Han and Harrison, 2006)

CG11887

(Han and Harrison, 2006, Han and Harrison, 2007, Han and Harrison, 2008)

StIP

(Han and Harrison, 2007, FBrf0198885, Han and Harrison, 2008)

Stip

(Han and Harrison, 2008)

Name Synonym

StIP

Secondary FlyBase IDs

References ( 11 )

Supplementary material

Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Abstract

Han and Harrison, 2008, A. Dros. Res. Conf. 49: 353B: The function of StIP in the JAK/STAT pathway. [FBrf0203820]
Han and Harrison, 2007, A. Dros. Res. Conf. 48: 442A: The function of StIP in the JAK/STAT pathway. [FBrf0198212]
Han and Harrison, 2006, A. Dros. Res. Conf. 47: 380A: The function of StIP in the JAK/STAT pathway. [FBrf0189403]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

Protein sequence record

: Putative elongator complex protein 2 (ELP2) (Stat3-interacting protein homolog). [FBrf0198885]

Computer file

Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection.: Genomic mapping of Exelixis insertion collection. [FBrf0184340]
Gene Disruption Project members, 2001-, [title not yet available]: [title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]

Automatic genome annotation

FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126705]