A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\CG16728

General Information
SymbolDmel\CG16728SpeciesD. melanogaster
NameCG16728Annotation symbolCG16728
Feature typeprotein_coding_geneFlyBase IDFBgn0033539
Created / Updated2004-08-09/2004-08-09
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map47B1-47B1Sequence location2R:6,529,319..6,532,921 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol CG16728 (FBgn0033539). It has the cytological map location 47B1. Its sequence location is 2R:6529319..6532921. Its molecular function is described as: ARF GTPase activator activity; zinc ion binding. It is involved in the biological process regulation of ARF GTPase activity. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
47B1-47B1  
Limits computationally determined from genome sequence between P{PZ}lola00349&P{EP}lolaEP952 and P{lacW}l(2)k00909k00909&P{EP}EP2619EP2619  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\CG16728 for information on other features
detailed view FBtr0088284 FBtr0088283 FBtr0113063 FBtr0088258 FBtr0088212 FBpp0111976 FBpp0087375 FBpp0087376 FBpp0087353 FBpp0087307 FBti0045316 FBti0048999 FBti0051330 FBti0038901 FBti0065185 FBti0065854 FBti0065830
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
CG16728-RA
FBtr0088258
 NM_136755
  2496
  731
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
CG16728-PA  
FBpp0087353  
80.8  
731  
6.41  
  NP_610599
  AAF58766
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Arf GTPase activating protein (IPR001164)
Ankyrin (IPR002110)
Spa2 homology (SHD) of GIT (IPR013724)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA202101
 
AA439348
 
AA940924
 
AA941032
 
AA942636
 
AA950502
 
AA979634
 
AE003828
AAF58766
 
AI061908
 
AI259417
 
AI259992
 
AI456224
 
AI512393
 
AI514549
 
AI514840
 
AI515802
 
AI516468
 
AI518344
 
AI519976
 
AI520085
 
AI520182
 
AI520579
 
AI534188
 
AI534571
 
AI534638
 
AT01037
 
AT01086
 
AW943022
 
AY061380
AAL28928
 
BF487336
 
BF492523
 
BF492524
 
BF492604
 
BF492605
 
BG634504
 
BI169157
 
BI173426
 
BI215143
 
BI240923
 
BI356642
 
BI358175
 
BI635144
 
BI640838
 
BQ102967
 
CO265486
 
CO266108
 
CO269245
 
CO282917
 
CO308125
 
CO321080
 
CO339007
 
CZ469856
 
CZ482470
 
CZ482471
 
CZ486164
 
EC064951
 
EC071182
 
EC084449
 
EC199012
 
EC210375
 
EC210376
 
EC236590
 
EC245500
 
EC252731
 
EC254254
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0088284 FBtr0088283 FBtr0113063 FBtr0088258 FBtr0088212
        AA950502
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 3 )
        For All Classical Alleles Show

        Allele of CG16728ClassMutagenStocksKnown lesion
        CG16728c052971 --
        CG16728e046901 --
        CG16728f035861 --
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of CG16728ClassMutagenStocksKnown lesion
        CG16728GD148010 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD14801}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        miscellaneous insertions
        PBac{PB}CG16728c05297
        NA
        PBac{RB}CG16728e04690
        NA
        PBac{WH}CG16728f03586
        NA
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 3 )
        hide Molecular Function
        CV term
        Evidence
        References
        ARF GTPase activator activity
        inferred from sequence or structural similarity with EMBL:AF124490; protein_id:AAD28046.1
        (FlyBase, 1992-)
        zinc ion binding
        inferred from electronic annotation with InterPro:IPR001164
        (FlyBase Curators et al., 2004-)
        hide Biological Process
        CV term
        Evidence
        References
        regulation of ARF GTPase activity
        inferred from electronic annotation with InterPro:IPR001164
        (FlyBase Curators et al., 2004-)
        hide Cellular Component
        CV term
        Evidence
        References
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        CG16728 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 3 )
        Harvard
        -
        PBac{PB}CG16728c05297
        -
        PBac{RB}CG16728e04690
        -
        PBac{WH}CG16728f03586
        hide Genomic Clones ( 2 )
        hide cDNA Clones ( 45 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Arf GTPase activating protein (IPR001164)
        Ankyrin (IPR002110)
        Spa2 homology (SHD) of GIT (IPR013724)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 2 )
        Reported As
        Symbol Synonym
        CG16728
        (Bakal, 2007, Bakal et al., 2007)
        CT37209
        (Wheeler and Hynes, 2001)
        Name Synonym
        CG16728
         
        Secondary FlyBase IDs
          hide References ( 13 )
          Research paper
          Bakal, 2007, Science 316(5832): 1753--1756
          [FBrf0204467]
          Wheeler and Hynes, 2001, Gene 262(1-2): 291--299
          The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila. [FBrf0134629]
          Supplementary material
          Bakal et al., 2007, Science 316(5832):
          Supporting online material. [FBrf0204776]
          Dietzl et al., 2007, Nature 448(7150):
          Supplementary Table 1. [FBrf0202579]
          Giot et al., 2003, Science 302(5651):
          Tables S1 to S7. [FBrf0166452]
          Review
          Bernards, 2003, Biochim. biophys. Acta 1603(2): 47--82
          GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. [FBrf0158741]
          Personal communication to FlyBase
          FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
          Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
          FlyBase analysis
          FlyBase, 1992-, FlyBase curation
          FlyBase curation. [FBrf0105495]
          Computer file
          Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection.
          Genomic mapping of Exelixis insertion collection. [FBrf0184340]
          Gene Disruption Project members, 2001-, [title not yet available]
          [title not yet available] [FBrf0132177]
          BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
          Berkeley Drosophila Genome Project. [FBrf0125078]
          Automatic genome annotation
          FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]
          [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
          Curated genome annotation
          Li, 1999.11, [Annotations performed at the Celera Jamboreee.]
          [Annotations performed at the Celera Jamboreee.] [FBrf0126682]