Gene Dmel\CG12896

Help

Close All Open All

General Information

Symbol

Dmel\CG12896

Species

D. melanogaster

Name

CG12896

Annotation symbol

CG12896

Feature type

protein_coding_gene

FlyBase ID

FBgn0033521

Created / Updated

2003-12-02/2003-12-02

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

47A7-47A7

Sequence location

2R:6,314,387..6,315,418 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG12896 (FBgn0033521). It has the cytological map location 47A7. Its sequence location is 2R:6314387..6315418. Its molecular function is described as: oxidoreductase activity; antioxidant activity. It is involved in the biological process mesoderm development. No alleles are reported. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47A7-47A7

Limits computationally determined from genome sequence between P{lacW}Hr46^k10308 and P{PZ}lola⁰⁰³⁴⁹&P{EP}lola^EP952

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG12896 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG12896-RA

FBtr0088315

NM_136740

844

220

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG12896-PA

FBpp0087406

24.8

220

6.39

NP_610584

AAF58796

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0033521

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen (IPR000866)

Thioredoxin fold (IPR012335)

Thioredoxin-like fold (IPR012336)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

(Oliver, 2001.8.16)

LD11278

(White et al., 1999)

RE05501

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

13072

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033521

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0033521

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG12896	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG12896	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Useful deficiency

Df(2R)stan2

Useful duplication

Dp(2;2)Y3b

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}CG6751^KG03665

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

antioxidant activity

inferred from electronic annotation with InterPro:IPR000866

(FlyBase Curators et al., 2004-)

oxidoreductase activity

inferred from electronic annotation with InterPro:IPR000866

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

mesoderm development

inferred from expression pattern

(Furlong et al., 2001)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG12896 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61919

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Dpse\GA11887

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000020201
Anopheles gambiae (Ensembl)
AT1G48130.1
Arabidopsis thaliana (Arabidopsis)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

Bloomington

13025

y¹ w^67c23; P{SUPor-P}KG03665

Genomic Clones ( 1 )

BACR20O22

cDNA Clones ( 2 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE05501

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

EP15641

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0033521

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0033521

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_136740

RefSeq (Proteins)

•

NP_610584

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen (IPR000866)

Thioredoxin fold (IPR012335)

Thioredoxin-like fold (IPR012336)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61919

DEDB - Drosophila exon database: splicing graphs

•

13072

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0033521

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033521

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0033521

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0033521

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0033521

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000020201
Anopheles gambiae (Ensembl)
AT1G48130.1
Arabidopsis thaliana (Arabidopsis)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0033521

University of Chicago Dev. Expression

•

FBgn0033521

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

BEST:LD11278

CG12896

Name Synonym

AOP2-related

(White et al., 1999)

CG12896

Secondary FlyBase IDs

FBgn0040497

References ( 7 )

Research paper

Furlong et al., 2001, Science 293(5535): 1629--1633: Patterns of gene expression during Drosophila mesoderm development. [FBrf0138533]
White et al., 1999, Science 286(5447): 2179--2184: Microarray analysis of Drosophila development during metamorphosis. [FBrf0123240]

Personal communication to FlyBase

FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348).: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

Computer file

Gene Disruption Project members, 2001-, [title not yet available]: [title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]