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Gene Dmel\CG12214

General Information
Symbol	Dmel\CG12214	Species	D. melanogaster
Name	CG12214	Annotation symbol	CG12214
Feature type	protein_coding_gene	FlyBase ID	FBgn0033495
Created / Updated	2003-12-02/2003-12-02
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46F3-46F3	Sequence location	2R:6,043,875..6,046,385 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol CG12214 (FBgn0033495). It has the cytological map location 46F3. Its sequence location is 2R:6043875..6046385. Its molecular function is described as protein binding. The biological processes in which it is involved are not known. 9 alleles are reported. The phenotype of these alleles is annotated with wing. It has 2 annotated transcripts and 2 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46F3-46F3   Limits computationally determined from genome sequence between P{PZ}Pfk06339&P{PZ}CCS03221 and P{lacW}Hr46k10308
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\CG12214 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12214-RA FBtr0088370  NM_136718   2197   459 CG12214-RB FBtr0088369  NM_165754   2511   459
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12214-PA   FBpp0087458   53.1   459   5.13     NP_610562   AAF58828 CG12214-PB   FBpp0087457   53.1   459   5.13     NP_724901   AAM68775
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0033495
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540733   AA540889   AA567597   AA802670   AA803141   AE003830 AAF58828   AE003830 AAM68775   AI107119   AI107451   AI109340   AI135348   AI387113   AI402306   AI402841   AI404474   AI511620   AI511791   AI512115   AI513233   AY051458 AAK92882   BF499861   BI172031   BI172064   BI237554   BI241784   BI355493   BI361413   BI361451   BI366264   BI369622   BI481899   BI485100   BI486533   BI579754   CL705902   CO271233   CO285966   CO287686   CO300345   CO302799   CO303217   CO316541   CO322122   CZ472212   CZ473586   CZ477516   CZ477837   CZ490471   EC069887   EC085926   EC089421   EC200496   EC214424   EC234768   EC240170
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K549
Maps to
Does NOT map to
Identified with	GH13040 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI135348 AI258041
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033495 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0033495 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0033495 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG12214 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG12214EY02157 Sterility Allele fertile CG12214EY02157 Phenotype manifest in Allele wing | posterior compartment, with Scer\GAL4en-e16E CG12214UY1505
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of CG12214 Class Mutagen Stocks Known lesion CG12214EY02157 P-element activity 1 -- CG12214KG03017 0 -- CG12214UY1505 P-element activity 0 -- CG12214d01405 P-element activity 1 -- CG12214d03837 P-element activity 1 -- CG12214d10941 P-element activity 0 -- CG12214d11637 P-element activity 0 -- CG12214f07734 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12214 Class Mutagen Stocks Known lesion CG12214GD7531 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes
Aneuploid Aberrations
Useful deficiency	Df(2R)stan2
Useful duplication	Dp(2;2)Y3b
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7531} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG12214f07734 NA P{SUPor-P}CG12214KG03017 NA insertion of mobile activating element P{EPgy2}CG12214EY02157 NA P{EP}EP2118 NA P{Mae-UAS.6.11}CG12214UY1505 NA P{XP}CG12214d01405 NA P{XP}CG12214d03837 NA P{XP}CG12214d10941 NA P{XP}CG12214d11637 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 1 )
Molecular Function
CV term Evidence References
protein binding inferred from electronic annotation with InterPro:IPR001611 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12214 allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 61894
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12136 Dere\GG25228 Dgri\GH20121 Dmoj\GI20213 Dper\GL10489 Dpse\GA11483 Dsec\GM20547 Dsim\GD26002 Dvir\GJ20163 Dwil\GK10690 Dyak\GE21743
Curated drosophilid orthologs	Dpse\GA11483
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000012526 Anopheles gambiae (Ensembl) ENSBTAP00000024242 Bos taurus (Ensembl) ENSCAFP00000017451 Canis familiaris (Ensembl) NEWSINFRUP00000150346 Takifugu rubripes (Ensembl) ENSP00000284259 Homo sapiens (Ensembl) ENSMMUP00000000114 Macaca mulatta (Ensembl) ENSMODP00000016316 Monodelphis domestica (Ensembl) ENSPTRP00000007526 Pan troglodytes (Ensembl) ENSRNOP00000047676 Rattus norvegicus (Ensembl) GSTENP00026824001 Tetraodon nigroviridis (Ensembl) ENSXETP00000037159 Xenopus tropicalis (Ensembl) WBGene00034903 Caenorhabditis briggsae (Wormbase) WBGene00016866 Caenorhabditis elegans (Wormbase) ZDB-CDNA-040425-2659 Danio rerio (Zfin) ZDB-GENE-040426-1719 Danio rerio (Zfin) MGI:1925543 Mus musculus (Informatics)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Szeged	- P{EP}EP2118
Harvard	- P{XP}CG12214d01405 - P{XP}CG12214d03837 - PBac{WH}CG12214f07734
VDRC	v31689 w1118; P{GD7531}v31689
Bloomington	13767 y1 w67c23; P{SUPor-P}KG03017 20138 y1 w67c23; P{EPgy2}CG12214EY02157
Genomic Clones ( 1 )
	BACR09J12
cDNA Clones ( 38 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13040
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08491 RE55864 RE73832 LD43088 RE69975 RE33802 RE45667 LD20741 GH05142 AT14632 HL01511 GM10304 RE64516 RE13994 RE38951 LD43315 LD20523 GM31079 GH17549 GH22148 RE45618 GH24213 GH21317 RE68375 GM06080 RE51765 LD43840 RE13954 GH06426
Other clones	EK178006 EK066506 EK184922 EK240612 EK102462 EK187254 EK061321 EK265223
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0033495 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0033495
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165754 NM_136718 RefSeq (Proteins) • NP_724901 NP_610562 DDBJ / EMBL / GenBank • AE003830 AAF58828 AAM68775 AI135348 AI513233 AY051458 AAK92882 CL705902 CZ472212 CZ473586 CZ477516 CZ477837 CZ490471 UniProtKB/TrEMBL • Q7K549
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 61894 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0033495 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033495 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0033495 FlyExpress - Embryonic expression images (BDGP data) • FBgn0033495 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033495 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0033495 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0033495 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000012526 Anopheles gambiae (Ensembl) ENSBTAP00000024242 Bos taurus (Ensembl) ENSCAFP00000017451 Canis familiaris (Ensembl) NEWSINFRUP00000150346 Takifugu rubripes (Ensembl) ENSP00000284259 Homo sapiens (Ensembl) ENSMMUP00000000114 Macaca mulatta (Ensembl) ENSMODP00000016316 Monodelphis domestica (Ensembl) ENSPTRP00000007526 Pan troglodytes (Ensembl) ENSRNOP00000047676 Rattus norvegicus (Ensembl) GSTENP00026824001 Tetraodon nigroviridis (Ensembl) ENSXETP00000037159 Xenopus tropicalis (Ensembl) WBGene00034903 Caenorhabditis briggsae (Wormbase) WBGene00016866 Caenorhabditis elegans (Wormbase) ZDB-CDNA-040425-2659 Danio rerio (Zfin) ZDB-GENE-040426-1719 Danio rerio (Zfin) MGI:1925543 Mus musculus (Informatics) PANTHER - Protein classification by function, families, and pathways • FBgn0033495 University of Chicago Dev. Expression • FBgn0033495
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12214
Name Synonym	CG12214
Secondary FlyBase IDs
References ( 8 )
Research paper	Raisin et al., 2003, Genetics 164(3): 1015--1025 A new genetic locus controlling growth and proliferation in Drosophila melanogaster. [FBrf0160859]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]