Gene Dmel\CG1599

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General Information

Symbol

Dmel\CG1599

Species

D. melanogaster

Name

CG1599

Annotation symbol

CG1599

Feature type

protein_coding_gene

FlyBase ID

FBgn0033452

Created / Updated

2003-12-02/2003-12-02

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

46B4-46B4

Sequence location

2R:5,728,579..5,730,014 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG1599 (FBgn0033452). It has the cytological map location 46B4. Its sequence location is 2R:5728579..5730014. Its molecular function is described as SNAP receptor activity. It is involved in the biological processes: intracellular protein transport; vesicle-mediated transport. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

46B4-46B4

Limits computationally determined from genome sequence between P{lacW}l(2)k05420^k05420 and P{lacW}l(2)k07803^k07803&P{lacW}l(2)k08816^k08816

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG1599 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG1599-RA

FBtr0089394

NM_136680

1107

218

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG1599-PA

FBpp0088416

24.9

218

8.69

NP_610524

AAF58892

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0033452

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Synaptobrevin (IPR001388)

Longin (IPR010908)

Longin-like (IPR011012)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q7JYX5

Maps to

Does NOT map to

Identified with

RH15778

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

13152

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033452

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0033452

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0033452

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

CG1599^EY09354

Sterility

Allele

fertile

CG1599^EY09354

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG1599	Class	Mutagen	Stocks	Known lesion
CG1599^EY09354		P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG1599	Class	Mutagen	Stocks	Known lesion
CG1599^GD4531		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD4531}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}CG1599^EY09354

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 5 )

Molecular Function

CV term

Evidence

References

SNAP receptor activity

non-traceable author statement

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

intracellular protein transport

inferred by curator from GO:0005484

(FlyBase, 1992-)

vesicle-mediated transport

inferred from electronic annotation with InterPro:IPR001388, InterPro:IPR010908

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from electronic annotation with InterPro:IPR001388, InterPro:IPR010908

(FlyBase Curators et al., 2004-)

plasma membrane

inferred from sequence or structural similarity with UniProtKB:P51809

(FlyBase, 1992-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG1599 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61844

Drosophila PIMRider - The Drosophila Protein Interaction map

•

521803

Orthologs

Genome-wide drosophilid orthologs

Dana\GF11075

Dere\GG25257

Dgri\GH21327

Dmoj\GI20745

Dper\GL20026

Dpse\GA14039

Dsec\GM20575

Dsim\GD10048

Dvir\GJ20482

Dwil\GK20965

Dyak\GE22017

Curated drosophilid orthologs

Dpse\GA14039

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011948
Anopheles gambiae (Ensembl)
ENSBTAP00000021538
Bos taurus (Ensembl)
ENSCAFP00000029056
Canis familiaris (Ensembl)
NEWSINFRUP00000167627
Takifugu rubripes (Ensembl)
ENSGALP00000031702
Gallus gallus (Ensembl)
ENSP00000262640
Homo sapiens (Ensembl)
ENSMODP00000007638
Monodelphis domestica (Ensembl)
ENSPTRP00000038738
Pan troglodytes (Ensembl)
ENSRNOP00000011065
Rattus norvegicus (Ensembl)
GSTENP00007046001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000039822
Xenopus tropicalis (Ensembl)
Q9LWK1
Oryza sativa (Gramene)
AT2G25340.1
Arabidopsis thaliana (Arabidopsis)
ZDB-CDNA-040425-1987
Danio rerio (Zfin)
ZDB-GENE-040426-1055
Danio rerio (Zfin)
DDB0231542
Dictyostelium discoideum (Dictybase)
MGI:1096399
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

VDRC

v13316

w¹¹¹⁸ P{GD4531}v13316

v13317

w¹¹¹⁸; P{GD4531}v13317

Bloomington

16934

y¹ w^67c23; P{EPgy2}CG1599^EY09354

Genomic Clones ( 2 )

cDNA Clones ( 20 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RH15778

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0033452

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0033452

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Expression is enriched in embryonic gonads.

(Shigenobu et al., 2006)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_136680

RefSeq (Proteins)

•

NP_610524

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q7JYX5

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Synaptobrevin (IPR001388)

Longin (IPR010908)

Longin-like (IPR011012)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61844

DEDB - Drosophila exon database: splicing graphs

•

13152

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0033452

Drosophila PIMRider - The Drosophila Protein Interaction map

•

521803

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033452

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0033452

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0033452

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0033452

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0033452

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011948
Anopheles gambiae (Ensembl)
ENSBTAP00000021538
Bos taurus (Ensembl)
ENSCAFP00000029056
Canis familiaris (Ensembl)
NEWSINFRUP00000167627
Takifugu rubripes (Ensembl)
ENSGALP00000031702
Gallus gallus (Ensembl)
ENSP00000262640
Homo sapiens (Ensembl)
ENSMODP00000007638
Monodelphis domestica (Ensembl)
ENSPTRP00000038738
Pan troglodytes (Ensembl)
ENSRNOP00000011065
Rattus norvegicus (Ensembl)
GSTENP00007046001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000039822
Xenopus tropicalis (Ensembl)
Q9LWK1
Oryza sativa (Gramene)
AT2G25340.1
Arabidopsis thaliana (Arabidopsis)
ZDB-CDNA-040425-1987
Danio rerio (Zfin)
ZDB-GENE-040426-1055
Danio rerio (Zfin)
DDB0231542
Dictyostelium discoideum (Dictybase)
MGI:1096399
Mus musculus (Informatics)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0033452

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG1599

(Shigenobu et al., 2006)

Name Synonym

CG1599

Secondary FlyBase IDs

References ( 12 )

Research paper

Shigenobu et al., 2006, Proc. Natl. Acad. Sci. USA 103(37): 13728--13733: Molecular characterization of embryonic gonads by gene expression profiling in Drosophila melanogaster. [FBrf0193273]

Supplementary material

Kiger et al., 2003, J. Biol. 2(4):: Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]

Review

Filippini et al., 2001, Trends Biochem. Sci. 26(7): 407--409: Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. [FBrf0182780]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Bock, 2000.10.26, FlyBase error report for CG1599 on Thu Oct 26 01:05:17 2000.: FlyBase error report for CG1599 on Thu Oct 26 01:05:17 2000. [FBrf0131193]
Verstreken and Bellen, 2000.9.4, New genes and synaptic vesicle cycle proteins.: New genes and synaptic vesicle cycle proteins. [FBrf0131218]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

Computer file

Gene Disruption Project members, 2001-, [title not yet available]: [title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]

Automatic genome annotation

FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126705]

Curated genome annotation

Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126677]