A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\CG10621

General Information
SymbolDmel\CG10621SpeciesD. melanogaster
NameCG10621Annotation symbolCG10621
Feature typeprotein_coding_geneFlyBase IDFBgn0032726
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map37B7-37B7Sequence location2L:18,952,206..18,954,421 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol CG10621 (FBgn0032726). It has the cytological map location 37B7. Its sequence location is 2L:18952206..18954421. Its molecular function is described as: selenocysteine methyltransferase activity; homocysteine S-methyltransferase activity. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
37B7-37B7  
Limits computationally determined from genome sequence between P{EP}CG10413EP2164 and P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\CG10621 for information on other features
detailed view FBtr0081132 FBtr0081192 FBtr0081191 FBtr0081190 FBpp0080676 FBpp0080733 FBpp0080732 FBpp0080731 FBti0026252 FBti0010815 FBti0021750 FBti0053083 FBti0065412
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
CG10621-RA
FBtr0081191
 NM_136076
  1292
  331
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
CG10621-PA  
FBpp0080732  
36.8  
331  
4.49  
  NP_609920
  AAF53725
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Homocysteine S-methyltransferase (IPR003726)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA202654
 
AA264067
 
AA567917
 
AA942088
 
AE003661
AAF53725
 
AI257156
 
AI259324
 
AI296517
 
AI513147
 
AI534749
 
AX154664
 
AY128485
AAM75078
 
BG638465
 
BI166197
 
BI482135
 
BI567937
 
BI568243
 
BI577303
 
BI578960
 
BI614274
 
BI620676
 
BI629131
 
BI630766
 
BT030804
 
CA803198
 
CK657737
 
CK661449
 
CO179584
 
CO180339
 
CO192515
 
EC196017
 
EC198561
 
EC209906
 
EC221532
 
EC226543
 
LD26123
 
SD07755
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (Zou et al., 2000)
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0081132 FBtr0081192 FBtr0081191 FBtr0081190
        AA942088
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of CG10621ClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of CG10621ClassMutagenStocksKnown lesion
        CG10621GD70372 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Disrupted in
        (Ryder, 2004.4.26)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD7037}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        insertion of enhancer trap
        P{lacW}l(2)SH0420SH0420
        No
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 2 )
        hide Molecular Function
        CV term
        Evidence
        References
        homocysteine S-methyltransferase activity
        inferred from electronic annotation with InterPro:IPR003726
        (FlyBase Curators et al., 2004-)
        selenocysteine methyltransferase activity
        inferred from sequence or structural similarity with UniProtKB:P56707
        (FlyBase, 1992-)
        hide Biological Process
        CV term
        Evidence
        References
        hide Cellular Component
        CV term
        Evidence
        References
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        CG10621 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        Drosophila PIMRider - The Drosophila Protein Interaction map
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 2 )
        VDRC
        v31290
        w1118; P{GD7037}v31290/TM3
        v31291
        w1118; P{GD7037}v31291/TM3
        hide Genomic Clones ( 2 )
        hide cDNA Clones ( 26 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Source for merge of: CG10621 BEST:LD26123
        (Rana, 2004.7.8)
        Source for merge of: CG10621 anon-WO0140519.13 Source for merge of CG10621 anon-WO0140519.13 was sequence comparison (date:051113).
        (FlyBase, 1996-)
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Homocysteine S-methyltransferase (IPR003726)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        Drosophila PIMRider - The Drosophila Protein Interaction map
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        University of Chicago Dev. Expression
        •
        hide Synonyms & Secondary IDs ( 4 )
        Reported As
        Symbol Synonym
        anon-WO0140519.13
         
        BEST:LD26123
         
        CG10621
        (Vinci and Clarke, 2007)
        Name Synonym
        CG10621
         
        selenocysteine methyltransferase
        (Zhang et al., 2004)
        Secondary FlyBase IDs
        • FBgn0043797
        • FBgn0044752
        hide References ( 15 )
        Research paper
        Vinci and Clarke, 2007, J. Biol. Chem. 282(12): 8604--8612
        Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cervisiae. [FBrf0200360]
        Zhang et al., 2004, Dev. Biol. 270(2): 290--307
        The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. [FBrf0178963]
        Zinke et al., 2002, EMBO J. 21(22): 6162--6173
        Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. [FBrf0151960]
        Jin et al., 2001, Nature Genetics 29(4): 389--395
        The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. [FBrf0141676]
        Zou et al., 2000, Proc. Natl. Acad. Sci. USA 97(25): 13726--13731
        Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. [FBrf0131436]
        Supplementary material
        Giot et al., 2003, Science 302(5651):
        Tables S1 to S7. [FBrf0166452]
        Oh et al., 2003, Genetics 163(1):
        Table S1. [FBrf0157097]
        Personal communication to FlyBase
        Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
        RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
        FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
        Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
        Rana, 2004.7.8, BLAST analysis.
        BLAST analysis. [FBrf0178762]
        Ryder, 2004.4.26, Exelixis CG deletion data.
        Exelixis CG deletion data. [FBrf0184335]
        FlyBase analysis
        FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
        FlyBase inference based on genome sequence analysis. [FBrf0104946]
        FlyBase, 1992-, FlyBase curation
        FlyBase curation. [FBrf0105495]
        Computer file
        BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
        Berkeley Drosophila Genome Project. [FBrf0125078]
        Patent
        Greenspan, 2001.6.7, World Patent 0140519-A:
        Methods for identifying modulators for balance related disorders. [FBrf0141245]