A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Snoo

General Information
SymbolDmel\SnooSpeciesD. melanogaster
NameSno oncogeneAnnotation symbolCG34421
Feature typeprotein_coding_geneFlyBase IDFBgn0085450
Created / Updated2003-12-01/2007-06-28
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map28D3-28D3Sequence location2L:7,892,316..7,984,158 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Sno oncogene is referred to in FlyBase by the symbol Snoo (CG34421, FBgn0085450). It has the cytological map location 28D3. Its sequence location is 2L:7892316..7984158. Its molecular function is described as: protein binding; nucleotide binding. It is involved in the biological processes: negative regulation of transforming growth factor beta receptor signaling pathway; neuron development. 18 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: nervous system; adult segment; adult mesothoracic segment; thoracic segment; organ system; adult; adult brain; peripheral nervous system; larval head segment; imaginal precursor. It has 5 annotated transcripts and 5 annotated polypeptides.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
28D3-28D3  
Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
28D3-28D3
 
(Oh et al., 2003)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Snoo for information on other features
detailed view FBtr0079557 FBtr0079555 FBtr0112720 FBtr0112717 FBtr0112718 FBtr0079531 FBtr0079529 FBtr0079530 FBtr0112721 FBtr0112719 FBpp0079179 FBpp0079177 FBpp0111629 FBpp0111633 FBpp0111632 FBpp0111630 FBpp0111631 FBpp0079152 FBpp0079151 FBpp0079153 FBti0044061 FBti0047712 FBti0049568 FBti0050799 FBti0051854 FBti0025909 FBti0024212 FBti0028207 FBti0028281 FBti0028708 FBti0021801 FBti0011195 FBti0035371 FBti0057799
Comments on Gene Model
Gene merge based on EST/cDNA data.
DGC clone GH28569 appears problematic: incomplete CDS
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Snoo-RB
FBtr0112717
 NM_001103645
  7214
  1223
Snoo-RC
FBtr0112718
 NM_001103646
  5874
  1223
Snoo-RD
FBtr0112719
 NM_001103647
  6307
  1223
Snoo-RE
FBtr0112720
 NM_001103648
  6771
  398
Snoo-RF
FBtr0112721
 NM_001103649
  5168
  403
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Snoo-PB  
FBpp0111629  
135.1  
1223  
5.87  
  NP_001097115
  ABV53643
Snoo-PC  
FBpp0111630  
135.1  
1223  
5.87  
  NP_001097116
  ABV53644
Snoo-PD  
FBpp0111631  
135.1  
1223  
5.87  
  NP_001097117
  ABV53645
Snoo-PE  
FBpp0111632  
45.2  
398  
8.60  
  NP_001097118
  ABV53646
Snoo-PF  
FBpp0111633  
44.6  
403  
7.25  
  NP_001097119
  ABV53647
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Putative DNA binding (IPR009061)
Transforming protein Ski (IPR003380)
SAND-like (IPR010919)
c-SKI Smad4 binding (IPR014890)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AB082484
 
AE003619
AAF52579
 
AE003619
AAF52581
 
AI107524
 
AI405630
 
AI517370
 
AI517564
 
AM282580
CAK54355
 
AM282581
CAK54357
 
AM282582
CAK54356
 
AW941914
 
AY051636
AAK93060
 
AY071768
 
BI565686
 
BI580245
 
BI635535
 
BP541317
 
CO186727
 
CO268224
 
CO275619
 
CO288942
 
CO289543
 
CO323233
 
CO330981
 
CO345345
 
DQ138812
ABA86418
 
DQ812095
ABH10625
 
DQ831950
ABJ09065
 
DQ831951
ABJ09066
 
DQ831952
ABJ09067
 
DQ831953
ABJ09068
 
DQ831954
ABJ09069
 
EC051686
 
EC052175
 
EC059611
 
EC061623
 
EC063198
 
EC063282
 
EC079302
 
EC082391
 
EC088555
 
EC196963
 
EC205021
 
EC206345
 
EC224442
 
EC231944
 
EC242825
 
EC245089
 
EC248956
 
EC252710
 
EC265644
 
EL876556
 
EL876777
 
EL876885
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        viable (with SnooSH1402)
        viable (with SnooEX8B)
        viable (with SnooEX9B)
        viable (with SnooEX10B)
        viable (with SnooBSC41)
        viable, with Scer\GAL4Act
        viable, with Scer\GAL4tub
        viable, with Scer\GAL4[-]:
        lethal (with SnooSH1402)
        lethal (with SnooEX8B)
        lethal (with SnooEX9B)
        lethal (with SnooEX10B)
        lethal (with SnooEX95A)
        lethal (with SnooEX34A)
        lethal (with SnooEX71B)
        lethal | recessive
        lethal | recessive | third instar larval stage
        lethal | partially (with SnooEX4B)
        lethal | partially (with SnooEX17B)
        lethal | partially (with SnooEX95A)
        lethal | partially (with SnooEX34A)
        lethal | partially (with SnooEX71B)
        lethal | partially (with SnooBSC41)
        lethal | first instar larval stage (with SnooSH1402)
        lethal | first instar larval stage (with SnooEX4B)
        lethal | third instar larval stage (with SnooEX4B)
        lethal | third instar larval stage (with SnooEX17B)
        lethal | pupal stage (with SnooSH1402)
        lethal | pupal stage (with SnooEX17B)
        lethal | pupal stage | recessive
        lethal, with Scer\GAL4Act
        lethal, with Scer\GAL4tub
        Other Phenotypes
        Allele
        visible | dominant, with Scer\GAL4[-]:
        visible, with Scer\GAL432B
        visible, with Scer\GAL4Bx-MS1096
        visible, with Scer\GAL4en-e16E
        visible, with Scer\GAL4ap-md544
        visible, with Scer\GAL4GMR.PF
        visible, with Scer\GAL4A9
        visible, with Scer\GAL4Act
        visible, with Scer\GAL4tub
        visible, with Scer\GAL4dpp.3KK
        neuroanatomy defective (with SnooSH1402)
        neuroanatomy defective (with SnooEX4B)
        Sterility
        Allele
        female sterile (with SnooEX4B)
        female sterile (with SnooEX17B)
        female sterile (with SnooBSC41)
        female sterile | partially (with SnooEX95A)
        female sterile | partially (with SnooEX34A)
        female sterile | partially (with SnooBSC41)
        female fertile (with SnooSH1402)
        female fertile (with SnooEX8B)
        female fertile (with SnooEX9B)
        female fertile (with SnooEX10B)
        female fertile (with SnooEX71B)
        female fertile (with SnooBSC41)
        female fertile | reduced, with Scer\GAL4[-]:
        Phenotype manifest in
        Allele
        wing vein | ectopic, with Scer\GAL4[-]:
        wing vein | ectopic, with Scer\GAL4Act
        wing vein | ectopic, with Scer\GAL4tub
        eye, with Scer\GAL4GMR.PF
        ommatidium, with Scer\GAL4GMR.PF
        wing blade, with Scer\GAL4Bx-MS1096
        wing vein, with Scer\GAL432B
        wing vein, with Scer\GAL4dpp.3KK
        wing blade, with Scer\GAL432B
        crossvein, with Scer\GAL432B
        wing, with Scer\GAL4ap-md544
        mesothoracic tergum, with Scer\GAL4ap-md544
        wing | posterior compartment, with Scer\GAL4en-e16E
        lamina (with SnooSH1402)
        lamina plexus (with SnooSH1402)
        photoreceptor cell R7 & axon (with SnooSH1402)
        photoreceptor cell R8 & axon (with SnooSH1402)
        medulla (with SnooSH1402)
        medulla neuropil (with SnooSH1402)
        wing, with Scer\GAL4A9
        wing vein, with Scer\GAL4A9
        crossvein, with Scer\GAL4A9
        dorsal mesothoracic disc, with Scer\GAL4A9
        imaginal disc, with Scer\GAL432B
        lamina (with SnooEX4B)
        lamina plexus (with SnooEX4B)
        photoreceptor cell R7 & axon (with SnooEX4B)
        photoreceptor cell R8 & axon (with SnooEX4B)
        medulla (with SnooEX4B)
        medulla neuropil (with SnooEX4B)
        hide Classical Alleles ( 14 )
        For All Classical Alleles Show

        Allele of SnooClassMutagenStocksKnown lesion
        SnooBSC41
          		0 Yes
          SnooEP2004
            		1 Yes
            SnooEP2510
              		0 Yes
              SnooEX10B0 Yes
              SnooEX17B0 Yes
              SnooEX34A0 Yes
              SnooEX4B0 Yes
              SnooEX71B0 Yes
              SnooEX8B0 Yes
              SnooEX95A0 Yes
              SnooEX9B0 Yes
              SnooGS-C517T0 Yes
              SnooGS18054
                		0 Yes
                SnooSH14021 Yes
                hide Alleles Carried on Transgenic Constructs ( 4 )
                For All Alleles Carried on Transgenic Constructs Show

                Allele of SnooClassMutagenStocksKnown lesion
                SnooGD121262 Yes
                SnooGD121762 Yes
                SnooScer\UAS.cRa
                  		0 Yes
                  SnooScer\UAS.cTa0 Yes
                  hide Aneuploid Aberrations
                  Useful duplication
                   
                  hide Transgenic Constructs & Insertions
                  Transgenic Constructs
                  Type of construct
                  Name
                  Expression data
                  UAS construct
                  P{GD12126}
                  NA
                  P{GD12176}
                  NA
                  P{UAS-Snoo.T}
                  NA
                  Insertions
                  Type of insertions
                  Name
                  Expression data
                  miscellaneous insertions
                  P{SUPor-P}KG08241
                  NA
                  insertion of enhancer trap
                  P{lacW}SnooSH1402
                  No
                  insertion of mobile activating element
                  P{EP}CG7231EP2510
                  NA
                  P{EP}SnooEP2004
                  NA
                  P{GSV1}EP-899EP-899
                  NA
                  P{GSV6}SnooGS18054
                  NA
                  hide Related Comments
                  Please look at the allele reports for the complete phenotype data
                  snoN has limited function in development, inhibiting TGF-β-induced wing vein formation during pupation.
                  (Ramel et al., 2007)
                  hide Gene Ontology: Function, Process & Cellular Component ( 5 )
                  hide Molecular Function
                  CV term
                  Evidence
                  References
                  nucleotide binding
                  inferred from electronic annotation with InterPro:IPR009061
                  (FlyBase Curators et al., 2004-)
                  protein binding
                  inferred from electronic annotation with InterPro:IPR014890
                  (FlyBase Curators et al., 2004-)
                  hide Biological Process
                  CV term
                  Evidence
                  References
                  negative regulation of transforming growth factor beta receptor signaling pathway
                  inferred from genetic interaction with FLYBASE:babo; FB:FBgn0011300 inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
                  (Ramel, 2007)
                  neuron development
                  inferred from mutant phenotype
                  (Takaesu et al., 2006)
                  hide Cellular Component
                  CV term
                  Evidence
                  References
                  nucleus
                  inferred from sequence or structural similarity with MGD:Ski; MGI:MGI:98310
                  (FlyBase, 1992-)
                  hide