• Home
• Tools
  • BLAST
  • GBrowse
  • QueryBuilder
  • TermLink
  • ImageBrowse
  • Interactions Browser
  • Apollo
  • CytoSearch
  • QuickSearch
  • Batch Download
  • Coordinate Converter
  • Google™ FlyBase
  • Find A Person
  • Update An Address
  • Add A New Person
• Files
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases FTP
  • Genomes FTP
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Synteny Table
  • Drosophilidae
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All resources
  • Interactive Fly
  • Textpresso for Fly
  • AAA site
  • BDGP
  • DHGP
  • DGRC
  • Model Organisms
  • Stock Collections:
  • Bloomington
  • DrosDel
  • Ehime
  • Exelixis (Harvard)
  • GDP (Baylor)
  • Kyoto
  • NIG-Fly
  • Szeged
  • Tucson
  • VDRC
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Known Problems
  • Contact FlyBase
• Archives
  • Prior Home Page
  • R4.3 BLAST
  • R4.3 GBrowse
  • Older Archives

Gene Dmel\lid

General Information
Symbol	Dmel\lid	Species	D. melanogaster
Name	little imaginal discs	Annotation symbol	CG9088
Feature type	protein_coding_gene	FlyBase ID	FBgn0031759
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26B2-26B2	Sequence location	2L:5,990,441..5,999,483 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene little imaginal discs is referred to in FlyBase by the symbol lid (CG9088, FBgn0031759). It has the cytological map location 26B2. Its sequence location is 2L:5990441..5999483. Its molecular function is described as: histone demethylase activity (H3-K4 specific); protein binding; DNA binding; zinc ion binding. The biological processes in which it is involved are not known. 7 alleles are reported. The phenotypes of these alleles are annotated with: imaginal disc; larval optic lobe; macrochaeta. It has 2 annotated transcripts and 2 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26B2-26B2   Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26A8-26A9 (determined by in situ hybridisation)   (Spradling et al., 1999) 26A8-26A9 26B1--2   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\lid for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lid-RA FBtr0079231  NM_078762   5945   1838 lid-RB FBtr0079232  NM_164671   5831   1838
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein lid-PA   FBpp0078862   204.0   1838   6.61     NP_523486   AAF52319 lid-PB   FBpp0078863   204.0   1838   6.61     NP_723140   AAN10569
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0031759
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • AT-rich interaction region (IPR001606) Zinc finger, PHD-type (IPR001965) Transcription factor jumonji/aspartyl beta-hydroxylase (IPR003347) Transcription factor jumonji, JmjN (IPR003349) Zinc finger, C5HC2-type (IPR004198) Zinc finger, FYVE/PHD-type (IPR011011) Transcription factor jumonji (IPR013129) PLU-1-like (IPR013637) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141324   AA247022   AA264684   AA392046   AA438310   AA439773   AA539356   AA539994   AA817642   AA820419   AA941152   AA941195   AA941311   AA951425   AA978916   AC004758   AE003612 AAF52319   AE003612 AAN10569   AI258919   AI456628   AI512101   AI512854   AI516773   AI519208   AI520222   AI520544   AI533855   AI544169   AW943514   AY095051 AAM11379   BF489801   BF496795   BF497145   BF497346   BF499957   BF504453   BG638921   BI169455   BI214299   BI231008   BI486506   BI486522   BI578350   BI624033   BI641665   BP543453   BP543454   BP555515   BP556996   BP556997   BQ103693   CK657958   CO153961   CO155819   CO188809   CO188908   CO190656   CO191021   CO264290   CO268970   CO269131   CO272497   CO273363   CO275819   CO285095   CO288837   CO292262   CO292959   CO301928   CO303703   CO320849   CO322437   CO328436   CO333046   CO344070   CO344395   EC057423   EC057857   EC058217   EC059956   EC075064   EC078764   EC082543   EC085475   EC090158   EC195711   EC197133   EC197190   EC198063   EC198130   EC205338   EC210194   EC211882   EC214651   EC219038   EC220808   EC221286   EC222132   EC224173   EC225892   EC229747   EC235611   EC244250   EC244573   EC247476   EC252578   EC255424   EC256258   EC265719   G01406   LD38721
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMJ7
Maps to	DS05973 (Gildea et al., 2000)
Does NOT map to
Identified with	LD19310 (Gildea et al., 2000) LD40310 (BDGP Project Members, 2000-) Dm0352 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 6582
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI519208 AI520222
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031759 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0031759 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0031759 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for lid FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for lid Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable lid17.1 lethal (with lid10424) lidk06801 lethal (with lidk06801) lid10424 lethal | recessive lid10424 lidk06801 lidunspecified semi-lethal lid10424 semi-lethal (with lid10424) lidk06801 semi-lethal (with lidk06801) lid10424 Phenotype manifest in Allele imaginal disc lid10424 larval optic lobe lid10424 macrochaeta | supernumerary lidunspecified
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of lid Class Mutagen Stocks Known lesion lid10424 P-element activity 1 Yes lid17.1 Δ2-3 0 Yes lidk06801 P-element activity 2 Yes lidunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lid Class Mutagen Stocks Known lesion lidGD14113 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes lidJmjC.mut.Scer\UAS.P\T in vitro construct | regulatory fusion in vitro construct | amino acid replacement 0 Yes lidScer\UAS.P\T.cSa in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(2L)AP1   Df(2L)GpdhA
Useful duplication	Dp(2;2)C619
Disrupted in	Df(2L)E110 (Gildea et al., 2000) Df(2L)Exel8017 (Ryder, 2004.4.26) Df(2L)GpdhA (Spradling et al., 1999, Gildea et al., 2000, BDGP Project Members, 1994-1999) Df(2L)cl-h3 (Gildea et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14113} NA P{UASp-lid.JmjC.mut} NA P{UASp-lid.S} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{UASp-YFP.CG32673.D67L}17 NA insertion of enhancer trap P{PZ}lid10424 Yes P{lacW}l(2)SH1035SH1035 No P{lacW}lidk06801 No insertion of mobile activating element P{GSV1}C386C386 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 5 )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001606 (FlyBase Curators et al., 2004-)
histone demethylase activity (H3-K4 specific) inferred from mutant phenotype (Secombe et al., 2007)
protein binding inferred from physical interaction with FLYBASE:dm; FB:FBgn0000472 (Secombe et al., 2007)
zinc ion binding inferred from electronic annotation with InterPro:IPR001965, InterPro:IPR011011 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR004198 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lid allele Gene References lid10424 ash1 (Gildea et al., 2000) CycE (Brumby et al., 2002) lidk06801 ash1 (Gildea et al., 2000) brm (Gildea et al., 2000) CycE (Brumby et al., 2002) trx (Gildea et al., 2000) unspecified dm (Secombe et al., 2007)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 60002 Drosophila PIMRider - The Drosophila Protein Interaction map • 521855
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14289 Dere\GG24264 Dgri\GH10714 Dmoj\GI11300 Dper\GL19092 Dpse\GA25342 Dsec\GM17977 Dvir\GJ12537 Dwil\GK15405 Dyak\GE18962
Curated drosophilid orthologs	Dpse\GA21532
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000013125 Anopheles gambiae (Ensembl) ENSBTAP00000027280 Bos taurus (Ensembl) ENSCAFP00000023837 Canis familiaris (Ensembl) ENSCINP00000012442 Ciona intestinalis (Ensembl) NEWSINFRUP00000150813 Takifugu rubripes (Ensembl) ENSGALP00000021168 Gallus gallus (Ensembl) ENSP00000261253 Homo sapiens (Ensembl) ENSMMUP00000027068