A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Hrs

General Information
SymbolDmel\HrsSpeciesD. melanogaster
NameHepatocyte growth factor regulated tyrosine kinase substrateAnnotation symbolCG2903
Feature typeprotein_coding_geneFlyBase IDFBgn0031450
Created / Updated2003-12-22/2003-12-22
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map23A3-23A3Sequence location2L:2,739,986..2,743,377 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Hepatocyte growth factor regulated tyrosine kinase substrate is referred to in FlyBase by the symbol Hrs (CG2903, FBgn0031450). It has the cytological map location 23A3. Its sequence location is 2L:2739986..2743377. Its molecular function is described as: protein binding; zinc ion binding. It is involved in the biological processes described with 12 unique terms, many of which group under: transport; exocytosis; synaptic transmission; secretion by cell; transmembrane receptor protein tyrosine kinase signaling pathway; endosome transport; cellular localization; enzyme linked receptor protein signaling pathway; vacuolar transport; cell motility; organelle organization and biogenesis; regulation of epidermal growth factor receptor signaling pathway. 11 alleles are reported. The phenotypes of these alleles are annotated with: larval garland cell; endosome; late endosome; eye-antennal disc; border follicle cell; wing margin; wing; wing margin bristle. It has 4 annotated transcripts and 4 annotated polypeptides.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
23A3-23A3  
Limits computationally determined from genome sequence between P{PZ}dpp10638 and P{EP}EP832  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
23A-23A
Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.  
(Lloyd et al., 2000)
23A-23A
 
(Bellen, 2000.3.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Hrs for information on other features
detailed view FBtr0077705 FBtr0077707 FBtr0077706 FBtr0077708 FBtr0089751 FBtr0299871 FBtr0089750 FBtr0089749 FBtr0077740 FBtr0077712 FBpp0077390 FBpp0077392 FBpp0077391 FBpp0077389 FBpp0088691 FBpp0088692 FBpp0289149 FBpp0088690 FBpp0077420 FBpp0077396 FBti0043238
Comments on Gene Model
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Hrs-RA
FBtr0089749
 NM_164497
  2251
  647
Hrs-RB
FBtr0089750
 NM_080360
  2713
  760
Hrs-RC
FBtr0089751
 NM_164496
  2665
  760
Hrs-RD
FBtr0299871
 
  833
  168
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Hrs-PA  
FBpp0088690  
72.4  
647  
6.21  
  NP_722831
  AAF51222
Hrs-PB  
FBpp0088691  
85.4  
760  
6.97  
  NP_525099
  AAF51221
Hrs-PC  
FBpp0088692  
85.4  
760  
6.97  
  NP_722830
  AAN10412
Hrs-PD  
FBpp0289149  
19.1  
168  
7.47  
 
 
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Zinc finger, FYVE-type (IPR000306)
VHS (IPR002014)
Ubiquitin interacting motif (IPR003903)
ENTH/VHS (IPR008942)
Zinc finger, FYVE/PHD-type (IPR011011)
Zinc finger, RING/FYVE/PHD-type (IPR013083)
Ubiquitin binding protein, Hrs/VPS27 (IPR017073)
Zinc finger, FYVE-related (IPR017455)
PDB - Protein Data Bank. An information portal to biological macromolecular structures
•
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA201467
 
AA264230
 
AA390860
 
AA392050
 
AA438386
 
AA540494
 
AA696289
 
AA941527
 
AA941657
 
AA948946
 
AA949211
 
AA949487
 
AA978437
 
AA979604
 
AE003582
AAF51221
 
AE003582
AAF51222
 
AE003582
AAN10412
 
AI133880
 
AI135040
 
AI257318
 
AI258237
 
AI260730
 
AI260855
 
AI293379
 
AI455684
 
AI456372
 
AI513580
 
AI514418
 
AI515948
 
AI516755
 
AI518030
 
AI518568
 
AI518637
 
AI518668
 
AI531480
 
AI532209
 
AI541811
 
AI546204
 
AW943039
 
AY051789
AAK93213
 
AY071846
AAL60055
 
BF498323
 
BG632708
 
BG638016
 
BG639279
 
BG640717
 
BI163885
 
BI173012
 
BI229305
 
BI229369
 
BI236027
 
BI357295
 
BI483511
 
BI566210
 
BI566222
 
BI582652
 
BI587678
 
BI588900
 
BI588948
 
BI619184
 
BI620937
 
BI626108
 
BI634297
 
BI635127
 
BI638517
 
BT001591
AAN71346
 
CK657652
 
CK658956
 
CK659203
 
CK660022
 
CK662308
 
CO153634
 
CO155912
 
CO156689
 
CO194917
 
CO306066
 
CO309914
 
CO313090
 
CO316912
 
CO318803
 
CO319419
 
CO324255
 
CO324309
 
CO324498
 
CO327249
 
CO327668
 
EC078047
 
EC200838
 
EC213918
 
EC214644
 
EC223762
 
EC225029
 
EC227281
 
EC250220
 
EC253265
 
EC260196
 
EC261244
 
EC264801
 
GH12653
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    (Lloyd, 2001.12.26)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    rescue fragment
    Hrs[+t11.5]
    2L:2,733,927..2,745,099
    linked_to=SmaI-SmaI_rfrag
    (Lloyd et al., 2002)
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0077705 FBtr0077707 FBtr0077706 FBtr0077708 FBtr0089751 FBtr0299871 FBtr0089750 FBtr0089749 FBtr0077740 FBtr0077712
        AI135040
        AI260855
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        lethal
        lethal | larval stage | recessive
        Other Phenotypes
        Allele
        visible, with Scer\GAL4bbg-C96
        increased cell size | somatic clone
        Phenotype manifest in
        Allele
        larval garland cell
        endosome
        late endosome | somatic clone
        eye-antennal disc | somatic clone
        border follicle cell | somatic clone
        wing margin, with Scer\GAL4bbg-C96
        wing, with Scer\GAL4C5
        wing margin, with Scer\GAL4C5
        wing margin bristle, with Scer\GAL4C5
        hide Classical Alleles ( 6 )
        For All Classical Alleles Show

        Allele of HrsClassMutagenStocksKnown lesion
        HrsAD200 --
        HrsAD210 --
        HrsAD220 --
        HrsAD230 --
        HrsAD240 --
        HrsD281 Yes
        hide Alleles Carried on Transgenic Constructs ( 5 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of HrsClassMutagenStocksKnown lesion
        Hrs+t11.50 Yes
        HrsGD98461 Yes
        HrsScer\UAS.cLa0 Yes
        HrsdsRNA.cRa0 Yes
        Hrshs.PB0 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Disrupted in
        (Christensen and Cook, 2006.5.16)
        (DiAntonio et al., 1993)
        (DiAntonio et al., 1993)
        (Ryder, 2004.4.26)
        (Ryder, 2004.4.26)
        (Lloyd et al., 2002, Littleton and Bellen, 1994)
        Not disrupted in
        (Littleton and Bellen, 1994)
        (DiAntonio et al., 1993, Littleton and Bellen, 1994)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD9846}
        NA
        characterization construct
        P{UAS-Hrs.L}
        NA
        P{genomic.L}
        NA
        heat-shock construct
        P{hs-Hrs.L}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 19 )
        hide Molecular Function
        CV term
        Evidence
        References
        protein binding
        non-traceable author statement
        (Stewart, 2002)
        zinc ion binding
        inferred from electronic annotation with InterPro:IPR011011
        (FlyBase Curators et al., 2004-)
        hide Biological Process
        CV term
        Evidence
        References
        border follicle cell migration
        inferred from mutant phenotype
        (Jekely et al., 2005)
        endocytosis
        non-traceable author statement
        (Gonzalez-Gaitan, 2003)
        inferred from mutant phenotype
        (Rives et al., 2006)
        endosome to lysosome transport
        traceable author statement
        (Lloyd et al., 2000)
        endosome transport
        traceable author statement
        (Stewart, 2002)
        exocytosis
        traceable author statement
        (Stewart, 2002)
        intracellular protein transport
        inferred from electronic annotation with InterPro:IPR002014
        (FlyBase Curators et al., 2004-)
        negative regulation of epidermal growth factor receptor signaling pathway
        non-traceable author statement
        (Stewart, 2002)
        neurotransmitter secretion
        non-traceable author statement
        (Lloyd et al., 2000)
        synaptic vesicle exocytosis
        inferred from sequence or structural similarity
        (Littleton, 2000)
        synaptic vesicle priming
        non-traceable author statement
        (Lloyd et al., 2000)
        torso signaling pathway
        non-traceable author statement
        (Stewart, 2002)
        vesicle organization and biogenesis
        non-traceable author statement
        (Gonzalez-Gaitan, 2003)
        hide Cellular Component
        CV term
        Evidence
        References
        cytoplasm
        non-traceable author statement
        (Lloyd et al., 2000)
        early endosome
        non-traceable author statement
        (Lloyd et al., 2000)
        endosome
        traceable author statement
        (Stewart, 2002)
        late endosome
        non-traceable author statement
        (Lloyd et al., 2000)
        synaptic vesicle
        non-traceable author statement
        (Lloyd et al., 2000)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Hrs allele
        Gene
        References
        unspecified
        l(2)gd1
        (Childress et al., 2006)
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        Drosophila PIMRider - The Drosophila Protein Interaction map
        •
        hide Orthologs
        Genome-wide drosophilid orthologs