Gene Dmel\CG17646

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General Information

Symbol

Dmel\CG17646

Species

D. melanogaster

Name

CG17646

Annotation symbol

CG17646

Feature type

protein_coding_gene

FlyBase ID

FBgn0031362

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

22B1-22B2

Sequence location

2L:1,732,526..1,750,613 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG17646 (FBgn0031362). It has the cytological map location 22B1-22B2. Its sequence location is 2L:1732526..1750613. Its molecular function is described as: ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATP binding. The biological processes in which it is involved are not known. 12 alleles are reported. The phenotype of these alleles is annotated with germ cell. It has 2 annotated transcripts and 2 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

22B1-22B2

Limits computationally determined from genome sequence between P{PZ}l(2)04111⁰⁴¹¹¹ and P{lacW}CG17646^k11021

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG17646 for information on other features

Comments on Gene Model

EST data support existence of multiple transcripts due to variable use of mini-exons

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG17646-RA

FBtr0077886

NM_134774

3420

766

CG17646-RB

FBtr0077885

NM_164436

2998

766

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG17646-PA

FBpp0077554

85.0

766

7.64

NP_608618

AAF51341

CG17646-PB

FBpp0077553

85.0

766

7.64

NP_722727

AAN10460

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0031362

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

ABC transporter-like (IPR003439)

AAA+ ATPase, core (IPR003593)

ABC-2 type transporter (IPR013525)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q8T9E6

Maps to

Does NOT map to

Identified with

GH05015

(Zou et al., 2000)

SD03967

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5673

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI064556
AI532445

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031362

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0031362

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0031362

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Sterility

Allele

fertile

CG17646^EY03935

Phenotype manifest in

Allele

germ cell | male, with Scer\GAL4^ptc-559.1

CG17646^EP2506

Classical Alleles ( 11 )

For All Classical Alleles Show

Allele of CG17646	Mutagen	Stocks	Known lesion
CG17646¹⁰		1	Yes
CG17646^CB02833	P-element activity	0	Yes
CG17646^DG05704	P-element activity	1	--
CG17646^EP2506		1	--
CG17646^EY03935	P-element activity	1	--
CG17646^d03488	P-element activity	1	--
CG17646^d04174	P-element activity	0	--
CG17646^d05547	P-element activity	1	--
CG17646^d11704	P-element activity	0	--
CG17646^f01287	piggyBac transposase	1	--
CG17646^k11021	P-element activity	0	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG17646	Class	Mutagen	Stocks	Known lesion
CG17646^GD809		in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(2L)frtz11

Disrupted in

Df(2L)Exel7007

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD809}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{WH}CG17646^f01287

P{PTT-GB}CG17646^CB02833

P{UASp-YFP.RabX2.D66L}CG17646¹⁰

P{wHy}CG17646^DG05704

insertion of enhancer trap

P{lacW}CG17646^k11021

insertion of mobile activating element

P{EPgy2}CG17646^EY03935

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR003439

(FlyBase Curators et al., 2004-)

ATPase activity, coupled to transmembrane movement of substances

inferred from sequence or structural similarity with EMBL:AY048757

(FlyBase, 1992-)

transporter activity

inferred from sequence or structural similarity with EMBL:AY048757

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

ATP-binding cassette (ABC) transporter complex

inferred from sequence or structural similarity with EMBL:AY048757

(FlyBase, 1992-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG17646 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

59593

Orthologs

Genome-wide drosophilid orthologs

Dana\GF14008

Dere\GG24808

Dgri\GH25202

Dmoj\GI17271

Dper\GL19654

Dpse\GA14594

Dsec\GM16832

Dsim\GD23112

Dvir\GJ22779

Dwil\GK18351

Dyak\GE17714

Curated drosophilid orthologs

Dpse\GA14594

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

NP_415635.3
Escherichia coliK12 (NCBI)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 9 )

PBac{WH}CG17646^f01287

Bloomington

21061

y¹ w^67c23; P{wHy}CG17646^DG05704

19913

y¹ w^67c23; P{EPgy2}CG17646^EY03935

9841

y¹ w^*; P{UASp-YFP.RabX2.D66L}CG17646¹⁰

Genomic Clones ( 2 )

cDNA Clones ( 24 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones