Gene Dmel\cactin

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General Information

Symbol

Dmel\cactin

Species

D. melanogaster

Name

cactin

Annotation symbol

CG1676

Feature type

protein_coding_gene

FlyBase ID

FBgn0031114

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

19D1-19D1

Sequence location

X:20,295,007..20,297,439 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol cactin (CG1676, FBgn0031114). It has the cytological map location 19D1. Its sequence location is X:20295007..20297439. Its molecular function is unknown. It is involved in the biological processes: dorsal/ventral axis specification; defense response; signal transduction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19D1-19D1

Limits computationally determined from genome sequence between P{EP}amn^EP1639&P{EP}amn^EP367 and P{EP}CG1702^EP1525

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\cactin for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

cactin-RA

FBtr0077305

NM_078698

2433

762

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

cactin-PA

FBpp0076997

91.3

762

8.78

NP_523422

AAF50904

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0031114

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

RE14858

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5264

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI531045

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031114

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0031114

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0031114

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^arm.PS

cactin^Scer\UAS.cLa

Sterility

Allele

fertile, with Scer\GAL4^arm.PS

cactin^Scer\UAS.cLa

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of cactin	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of cactin	Class	Mutagen	Stocks	Known lesion
cactin^GD9200		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
cactin^Scer\UAS.cLa		in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(1)HM44

Useful duplication

Dp(1;1)B^STAG

Disrupted in

Df(1)Exel6254

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD9200}

P{UAS-cactin.L}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

defense response

non-traceable author statement

(Lemaitre, 2000.12.20)

dorsal/ventral axis specification

inferred from genetic interaction with FLYBASE:cact; FB:FBgn0000250

(Lin et al., 2000)

signal transduction

non-traceable author statement

(Lemaitre, 2000.12.20)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

cactin allele

Gene

References

External Data

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

59332

Drosophila PIMRider - The Drosophila Protein Interaction map

•

522322

Orthologs

Genome-wide drosophilid orthologs

Dana\GF19092

Dere\GG19290

Dgri\GH17778

Dmoj\GI15124

Dper\GL15935

Dpse\GA25716

Dsec\GM23033

Dvir\GJ18982

Dwil\GK25491

Dyak\GE17882

Curated drosophilid orthologs

Dpse\GA14132

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011538
Anopheles gambiae (Ensembl)
ENSBTAP00000013697
Bos taurus (Ensembl)
ENSCAFP00000028335
Canis familiaris (Ensembl)
ENSCINP00000009819
Ciona intestinalis (Ensembl)
NEWSINFRUP00000165886
Takifugu rubripes (Ensembl)
ENSGALP00000000158
Gallus gallus (Ensembl)
ENSP00000221899
Homo sapiens (Ensembl)
ENSMODP00000008473
Monodelphis domestica (Ensembl)
ENSPTRP00000017458
Pan troglodytes (Ensembl)
GSTENP00028533001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000047821
Xenopus tropicalis (Ensembl)
Q851R1
Oryza sativa (Gramene)
AT1G03910.1
Arabidopsis thaliana (Arabidopsis)
WBGene00039889
Caenorhabditis briggsae (Wormbase)
WBGene00012230
Caenorhabditis elegans (Wormbase)
DDB0205717
Dictyostelium discoideum (Dictybase)
MGI:1917562
Mus musculus (Informatics)
SPBC2F12.12c
Schizosaccharomyces pombe (Sanger)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v32718

w¹¹¹⁸; P{GD9200}v32718

v32719

w¹¹¹⁸; P{GD9200}v32719

Genomic Clones ( 2 )

cDNA Clones ( 13 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE14858

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0031114

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0031114

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: cactin CG1676 Source for identity of cactin CG1676 was sequence comparison (date:000504).

(FlyBase, 1996-)

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_078698

RefSeq (Proteins)

•

NP_523422

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Other Crossreferences

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

59332

DEDB - Drosophila exon database: splicing graphs

•

5264

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0031114

Drosophila PIMRider - The Drosophila Protein Interaction map

•

522322

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031114

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0031114

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0031114

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0031114

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0031114

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011538
Anopheles gambiae (Ensembl)
ENSBTAP00000013697
Bos taurus (Ensembl)
ENSCAFP00000028335
Canis familiaris (Ensembl)
ENSCINP00000009819
Ciona intestinalis (Ensembl)
NEWSINFRUP00000165886
Takifugu rubripes (Ensembl)
ENSGALP00000000158
Gallus gallus (Ensembl)
ENSP00000221899
Homo sapiens (Ensembl)
ENSMODP00000008473
Monodelphis domestica (Ensembl)
ENSPTRP00000017458
Pan troglodytes (Ensembl)
GSTENP00028533001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000047821
Xenopus tropicalis (Ensembl)
Q851R1
Oryza sativa (Gramene)
AT1G03910.1
Arabidopsis thaliana (Arabidopsis)
WBGene00039889
Caenorhabditis briggsae (Wormbase)
WBGene00012230
Caenorhabditis elegans (Wormbase)
DDB0205717
Dictyostelium discoideum (Dictybase)
MGI:1917562
Mus musculus (Informatics)
SPBC2F12.12c
Schizosaccharomyces pombe (Sanger)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0031114

University of Chicago Dev. Expression

•

FBgn0031114

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

cactin

CG1676

Name Synonym

cactin

(Lin, 2000.3.14)

Secondary FlyBase IDs

References ( 8 )

Research paper

Lin et al., 2000, Mech. Dev. 94(1-2): 57--65: Cactin, a conserved protein that interacts with the Drosophila IkappaB protein Cactus and modulates its function. [FBrf0128552]

Supplementary material

Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
Lemaitre, 2000.12.20, Drosophila immunity genes.: Drosophila immunity genes. [FBrf0133282]

FlyBase analysis

FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]

DNA/RNA sequence record

Lin, 2000.3.14, GenBank/EMBL/DDBJ: AF245116: Drosophila melanogaster cactin mRNA, complete cds. [FBrf0127944]

Computer file

BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]