A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Syx16

General Information
SymbolDmel\Syx16SpeciesD. melanogaster
NameSyntaxin 16Annotation symbolCG1467
Feature typeprotein_coding_geneFlyBase IDFBgn0031106
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map19C6-19C6Sequence locationX:20,263,361..20,264,807 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Syntaxin 16 is referred to in FlyBase by the symbol Syx16 (CG1467, FBgn0031106). It has the cytological map location 19C6. Its sequence location is X:20263361..20264807. Its molecular function is described as SNAP receptor activity. It is involved in the biological processes: neurotransmitter secretion; vesicle-mediated transport; synaptic vesicle docking during exocytosis; intracellular protein transport. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
19C6-19C6  
Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
19C-19E
 
(Cordes, 1999.9.22)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: l(1)G0004+ Syx16-
(Cordes, 1999.9.22)
hide Gene Model & Products
Please see the GBrowse view of Dmel\Syx16 for information on other features
detailed view FBtr0113006 FBtr0077298 FBtr0077330 FBtr0077299 FBpp0111919 FBpp0076990 FBpp0077022 FBpp0076991 FBti0071497 FBti0038216 FBti0013232 FBti0071877 FBti0028947 FBti0035226
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Syx16-RA
FBtr0077330
 NM_078696
  1311
  352
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Syx16-PA  
FBpp0077022  
40.4  
352  
5.19  
  NP_523420
  AAF50914
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Target SNARE coiled-coil region (IPR000727)
Syntaxin, N-terminal (IPR006011)
Syntaxin/epimorphin, conserved site (IPR006012)
t-SNARE (IPR010989)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003571
AAF50914
 
AF188892
AAG17062
 
AI113714
 
AW940347
 
BF505864
 
BI213556
 
BI215108
 
BI606776
 
BI608598
 
BI614266
 
BT003305
AAO25065
 
CO288353
 
EC080594
 
EC206664
 
EC226730
 
EC241087
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0113006 FBtr0077298 FBtr0077330 FBtr0077299
        AI113714
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of Syx16ClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 6 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of Syx16ClassMutagenStocksKnown lesion
        Syx1670-329.MtnA.T:Hsap\MYC0 Yes
        Syx1670-329.Scer\UAS0 Yes
        Syx1670-352.MtnA.T:Hsap\MYC0 Yes
        Syx1670-352.Scer\UAS0 Yes
        Syx16GD36941 Yes
        Syx16MtnA.T:Hsap\MYC0 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        Disrupted in
        (Ryder, 2004.4.26)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD3694}
        NA
        P{UAS-Syx16.70-329}
        NA
        P{UAS-Syx16.70-352}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 9 )
        hide Molecular Function
        CV term
        Evidence
        References
        SNAP receptor activity
        inferred from sequence or structural similarity
        (Littleton, 2000)
        non-traceable author statement
        (Littleton et al., 1999)
        inferred from electronic annotation with InterPro:IPR006012
        (FlyBase Curators et al., 2004-)
        hide Biological Process
        CV term
        Evidence
        References
        intracellular protein transport
        inferred from electronic annotation with InterPro:IPR006012
        (FlyBase Curators et al., 2004-)
        neurotransmitter secretion
        non-traceable author statement
        (Lloyd et al., 2000)
        synaptic vesicle docking during exocytosis
        inferred from sequence or structural similarity
        (Littleton, 2000)
        vesicle-mediated transport
        non-traceable author statement
        (Lloyd et al., 2000)
        inferred from electronic annotation with InterPro:IPR010989
        (FlyBase Curators et al., 2004-)
        hide Cellular Component
        CV term
        Evidence
        References
        Golgi apparatus
        inferred from direct assay
        (Xu et al., 2002)
        Golgi membrane
        inferred by curator from GO:0016021|GO:0005794
        (Xu et al., 2002)
        integral to membrane
        inferred from direct assay
        (Xu et al., 2002)
        plasma membrane
        inferred from sequence or structural similarity
        (Littleton, 2000)
        non-traceable author statement
        (Littleton et al., 1999)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Syx16 allele
        Gene
        References
        Syx1670-352.Scer\UAS
        Nsf2
        (Xu et al., 2002)
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        Drosophila PIMRider - The Drosophila Protein Interaction map
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 1 )
        VDRC
        v8644
        w1118; P{GD3694}v8644
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 8 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: Syx16 CG1467
        (Verstreken and Bellen, 2000.9.4)
        Source for database merge of
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        (Kiger et al., 2003)
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Target SNARE coiled-coil region (IPR000727)
        Syntaxin, N-terminal (IPR006011)
        Syntaxin/epimorphin, conserved site (IPR006012)
        t-SNARE (IPR010989)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        Drosophila PIMRider - The Drosophila Protein Interaction map
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        University of Chicago Dev. Expression
        •
        hide Synonyms & Secondary IDs ( 11 )
        Reported As
        Symbol Synonym
        CG1467
        (Bock, 2000.10.26, )
        DmSyx16
        (McLennan, 2001.5.22)
        Dm Syx16
        (Littleton, 2000)
        dSyx16
        (Xu et al., 2002)
        dSyx 16
        (Shimada et al., 2006)
        Syx
        (Wagh et al., 2006)
        SYX16
        (Lloyd et al., 2000)
        Syx16
        (Lagow et al., 2007)
        Name Synonym
        syntaxin
        (Dumstrei et al., 2003)
        Syntaxin
        (Kittel et al., 2006, Wagh et al., 2006, Hossain et al., 2008)
        Syntaxin 16
        (McLennan, 2001.5.22)
        Secondary FlyBase IDs
          hide References ( 26 )
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          hide Recent research papers ( 3 )
          Lagow et al., 2007, PLoS Biol. 5(4): e72
          Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. [FBrf0201324]
          Shimada et al., 2006, Dev. Cell 10(2): 209--222
          Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. [FBrf0190217]
          Wagh et al., 2006, Neuron 49(6): 833--844
          Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. [FBrf0191329]
          Show all research papers ...