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Gene Dmel\wgn

General Information
Symbol	Dmel\wgn	Species	D. melanogaster
Name	wengen	Annotation symbol	CG6531
Feature type	protein_coding_gene	FlyBase ID	FBgn0030941
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17C5-17C6	Sequence location	X:18,518,082..18,528,936 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wengen is referred to in FlyBase by the symbol wgn (CG6531, FBgn0030941). It has the cytological map location 17C5-17C6. Its sequence location is X:18518082..18528936. Its molecular function is described as: tumor necrosis factor receptor activity; protein binding. It is involved in the biological processes: cell surface receptor linked signal transduction; apoptosis. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17C5-17C6   Limits computationally determined from genome sequence between P{EP}EP443EP443&P{EP}BxEP1383 and P{EP}Pk17EEP438
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\wgn for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wgn-RA FBtr0074617  NM_167626   2403   343
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein wgn-PA   FBpp0074388   37.8   343   8.58     NP_728186   AAF48864
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • TNFR/CD27/30/40/95 cysteine-rich region (IPR001368)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698288   AB085747 BAC01264   AE003509 AAF48864   AY115552 AAM66764   AY118385 AAM48414   BG636286   BG636487   BI167713   BI172125   BI232479   BI233209   BI240583   BI243182   BI356522   BI358516   BI632976   BI633571   BI639557   CO196176   CO269628   CO310182   CZ478501   EC060818   EC090984   EC198169   EC201137   EC202436   EC205594   EC225059   EC228535   EC230621   EC241362   EL886249
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7Z1X1 Q9VWS4
Maps to
Does NOT map to
Identified with	RE29502 (BDGP Project Members, 2000-) SD13923 (Kanda et al., 2002)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 3280
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI531029
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030941 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0030941 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0030941 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for wgn Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable wgne00637 Sterility Allele fertile wgne00637 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of wgn Class Mutagen Stocks Known lesion wgne00637 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wgn Class Mutagen Stocks Known lesion wgnC.Scer\UAS.T:Ivir\HA1 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wgnGD3427 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes wgnN.Scer\UAS.T:Ivir\HA1 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wgnScer\UAS.T:Zzzz\FLAG in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wgnScer\UAS.cMa in vitro construct | regulatory fusion 0 Yes wgndsRNA.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes wgnΔTNFR.Scer\UAS.T:Zzzz\FLAG in vitro construct | regulatory fusion in vitro construct | coding region fusion in vitro construct | deletion 0 Yes wgnΔcyt.Scer\UAS.T:Zzzz\FLAG in vitro construct | regulatory fusion in vitro construct | coding region fusion in vitro construct | deletion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)E128
Useful duplication	Dp(1;1)BSTAG
Disrupted in	Df(1)Exel7463 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3427} NA P{UAS-wengen-IR} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}wgne00637 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 5 )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with FLYBASE:egr; FB:FBgn0033483 (Kanda et al., 2002)
tumor necrosis factor receptor activity non-traceable author statement (Kanda, 2002.5.23) inferred from sequence or structural similarity with HGNC_gene:TNFRSF1A; HGNC:11916; OMIM:191190 (Kanda et al., 2002) non-traceable author statement (Leclerc and Reichhart, 2004)
Biological Process
CV term Evidence References
apoptosis non-traceable author statement (Lawen, 2003)
cell surface receptor linked signal transduction inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483 (Kanda et al., 2002)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from direct assay AND inferred from sequence or structural similarity with HGNC_gene:TNFRSF1A; HGNC:11916; OMIM:191190 (Kanda et al., 2002)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wgn allele Gene References wgndsRNA.Scer\UAS egr (Kanda et al., 2002)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 59161
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22405 Dere\GG18107 Dgri\GH12331 Dmoj\GI15577 Dper\GL27022 Dpse\GA27758 Dsec\GM22797 Dvir\GJ15183 Dwil\GK24955 Dyak\GE15508
Curated drosophilid orthologs
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{RB}wgne00637
VDRC	v9152 w1118; P{GD3427}v9152
Bloomington	17874 w1118 PBac{RB}wgne00637
Genomic Clones ( 1 )
	BACR17H16
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE29502
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE37457 SD14215 RE28553 RE40746 RE08159 SD22168 RE14090 RE45295 SD27691 SD26888 SD13923 HL04218 RE42691
Other clones	EK095405 EK220653 IP17529 EK001513
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0030941 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0030941
Antibody Information
Other Information
Discoverer
Etymology
	Etymology: gene is named "wengen" for a village at the foot of Mt. Eiger. (Kanda et al., 2002)
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: wgn CG6531 Source for identity of wgn CG6531 was sequence comparison (date:020710). (FlyBase, 1996-)
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167626 RefSeq (Proteins) • NP_728186 DDBJ / EMBL / GenBank • AB085747 BAC01264 AE003509 AAF48864 AY115552 AAM66764 AY118385 AAM48414 BG636286 BI233209 CZ478501 UniProtKB/TrEMBL • Q7Z1X1 Q9VWS4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • TNFR/CD27/30/40/95 cysteine-rich region (IPR001368)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 59161 DEDB - Drosophila exon database: splicing graphs • 3280 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0030941 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030941 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0030941 FlyExpress - Embryonic expression images (BDGP data) • FBgn0030941 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030941 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0030941 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0030941
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG6531   vader (Chaudhary, 2002.5.28) wgn (Alekseyenko et al., 2006, Jacobsen et al., 2006)
Name Synonym	Wengen (Leclerc and Reichhart, 2004, Kuranaga and Miura, 2007) wengen (Kanda, 2002.5.23)
Secondary FlyBase IDs
	FBgn0062834
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 7 ) Review  ( 9 ) Personal communication to FlyBase  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 )
Recent research papers ( 2 )
	Alekseyenko et al., 2006, Genes Dev. 20(7): 848--857 High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome. [FBrf0190534] Jacobsen et al., 2006, Genetics 174(4): 1973--1982 Functional analysis of genes differentially expressed in the Drosophila wing disc: role of transcripts enriched in the wing region. [FBrf0194659] Show all research papers ...
Recent reviews ( 1 )
	Kuranaga and Miura, 2007, Trends Cell Biol. 17(3): 135--144 Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. [FBrf0200869] Show all reviews ...