Gene Dmel\NFAT

General Information
Symbol	Dmel\NFAT	Species	D. melanogaster
Name	NFAT	Annotation symbol	CG11172
Feature type	protein_coding_gene	FlyBase ID	FBgn0030505
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	12A9-12B2	Sequence location	X:13,518,790..13,557,690 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol NFAT (CG11172, FBgn0030505). It has the cytological map location 12A9-12B2. Its sequence location is X:13518790..13557690. Its molecular function is described as: transcription factor activity; RNA polymerase II transcription factor activity. It is involved in the biological processes: transcription; regulation of transcription, DNA-dependent. 24 alleles are reported. The phenotypes of these alleles are annotated with: anterior fascicle; eye; dorsocentral bristle; scutellar bristle; trichogen cell; pupa; wing vein. It has 2 annotated transcripts and 2 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12A9-12B2 Limits computationally determined from genome sequence between P{EP}CG1640^EP1626 and P{EP}NFAT^EP1353&P{EP}NFAT^EP1508
Experimentally Determined Cytological Location
Cytogenetic map Notes References 12A8-12A10 (Huang, 1999.10.18) 12A8-12A10 (determined by in situ hybridisation) (Huang and Rubin, 2000) 12A8-12A10 (determined by in situ hybridisation) (Abdelilah-Seyfried et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\NFAT for information on other features
Comments on Gene Model
	EST data support existence of multiple transcripts due to variable use of 5' exons
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) NFAT-RA FBtr0073808 NM_078592 5858 1419 NFAT-RB FBtr0112980 NM_001103504 5646 1457
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein NFAT-PA FBpp0073639 150.7 1419 6.77 NP_511147 AAF48297 NFAT-PB FBpp0111893 155.8 1457 6.89 NP_001096974 ABW09408
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0030505
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cell surface receptor IPT/TIG (IPR002909) Nuclear factor of activated T cells (NFAT) (IPR008366) p53-like transcription factor, DNA-binding (IPR008967) Rel homology (IPR011539) Immunoglobulin-like fold (IPR013783) Immunoglobulin E-set (IPR014756)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391997 AA801630 AA816813 AA941009 AA950353 AA951593 AA979220 AE003493 AAF48297 AF195496 AAG28468 AI108246 AI109382 AQ025361 AQ025413 AQ025433 AQ073194 AQ073198 AQ073228 AQ073251 AW942165 BG638026 BG638661 BH740834 BH740835 BI215752 BT003742 AAO40817 BT015267 AAT94496 BT030307 CL706570 CO179193 CO179430 CO179448 CO181823 CO189434 CO196396 CO261817 CO261861 CO262016 CO262889 CO263099 CO263254 CO263324 CO263452 CO263455 CO265894 CO266294 CO271261 CO279329 CO282867 CO283080 CO283256 CO283933 CO284392 CO285778 CO290259 CO290262 CO290264 CO291116 CO291128 CO291415 CO293166 CO295433 CO296654 CO296690 CO297899 CO297975 CO298602 CO300246 CO302039 CO304479 CO307475 CO308827 CO310483 CO310887 CO311949 CO313897 CO321211 CO323264 CO324200 CO325800 CO330535 CO331987 CO332992 CO340139 CO343376 CO344119 CZ467895 CZ471477 CZ472456 CZ475653 CZ478499 CZ479450 DN154397 EC053617 EC056783 EC059336 EC060497 EC063486 EC065311 EC066298 EC066679 EC069860 EC070755 EC070776 EC070827 EC071469 EC075742 EC079314 EC082348 EC086138 EC087554 EC196514 EC196739 EC197851 EC199905 EC200739 EC201753 EC205227 EC206795 EC208158 EC208226 EC208285 EC208317 EC210419 EC210845 EC211254 EC211520 EC212548 EC212590 EC213007 EC214062 EC215999 EC216505 EC218150 EC218151 EC218831 EC222824 EC226468 EC228792 EC230869 EC231057 EC231209 EC231257 EC231351 EC233569 EC233940 EC237878 EC238085 EC241195 EC242576 EC242874 EC244599 EC245509 EC246183 EC246791 EC250827 EC251008 EC252793 EC255299 EC258548 LD12674

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86NT0 Q9GU53 Q9VYA6

Maps to
Does NOT map to
Identified with	LD10950 (BDGP Project Members, 2000-) LD28881 (BDGP Project Members, 2000-, Huang, 1999.10.18)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 2723
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for

Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030505 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0030505 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0030505 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for NFAT FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for NFAT Stage(s) 1-3 Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable NFAT^CA07788 NFAT^EY07123 viable, with Scer\GAL4[-]: NFAT^EP1353 semi-viable, with Scer\GAL4^Act5C.PI NFAT^Scer\UAS.cHa lethal \| recessive NFAT^PG128 NFAT^PG58 lethal, with Scer\GAL4^en-e16E NFAT^EP1335 Other Phenotypes Allele wild-type, with Scer\GAL4^dpp.blk1 NFAT^Scer\UAS.cHa wild-type, with Scer\GAL4^vg.PB NFAT^Scer\UAS.cHa visible, with Scer\GAL4^sca-537.4 NFAT^EP1335 visible, with Scer\GAL4^hs.2sev NFAT^EP1335 NFAT^EP1390 NFAT^EP1508 visible, with Scer\GAL4^en-e16E NFAT^EP1390 visible, with Scer\GAL4^ap-md544 NFAT^EP1508 visible, with Scer\GAL4^ey.PH NFAT^EP1335 NFAT^EP1390 NFAT^EP1508 neuroanatomy defective \| larval stage, with Scer\GAL4^elav-C155 NFAT^EP1335 NFAT^EP1353 NFAT^EP1508 Sterility Allele fertile NFAT^EY07123 Phenotype manifest in Allele anterior fascicle, with Scer\GAL4^elav-C155 NFAT^EP1335 NFAT^EP1353 NFAT^EP1508 anterior fascicle & synapse, with Scer\GAL4^elav-C155 NFAT^EP1335 NFAT^EP1353 NFAT^EP1508 eye, with Scer\GAL4^ey.PH NFAT^EP1335 NFAT^EP1390 NFAT^EP1508 eye, with Scer\GAL4^hs.2sev NFAT^EP1335 NFAT^EP1390 NFAT^EP1508 dorsocentral bristle, with Scer\GAL4^sca-537.4 NFAT^EP1335 scutellar bristle, with Scer\GAL4^sca-537.4 NFAT^EP1335 trichogen cell, with Scer\GAL4^sca-537.4 NFAT^EP1335 wing vein, with Scer\GAL4^en-e16E NFAT^EP1390 wing vein \| supernumerary, with Scer\GAL4^ap-md544 NFAT^EP1508 scutellar bristle \| supernumerary, with Scer\GAL4^ap-md544 NFAT^EP1508 dorsocentral bristle \| supernumerary, with Scer\GAL4^ap-md544 NFAT^EP1508 pupa, with Scer\GAL4^Act5C.PI NFAT^Scer\UAS.cHa
Classical Alleles ( 22 )
For All Classical Alleles Show