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Gene Dmel\Klp10A

General Information
Symbol	Dmel\Klp10A	Species	D. melanogaster
Name	Klp10A	Annotation symbol	CG1453
Feature type	protein_coding_gene	FlyBase ID	FBgn0030268
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10A6-10A6	Sequence location	X:11,024,269..11,031,056 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Klp10A (CG1453, FBgn0030268). It has the cytological map location 10A6. Its sequence location is X:11024269..11031056. Its molecular function is described as: motor activity; microtubule motor activity; ATP binding. It is involved in the biological processes: mitotic sister chromatid segregation; microtubule-based movement; mitotic anaphase A; mitotic spindle organization and biogenesis; spindle organization and biogenesis. 10 alleles are reported. The phenotypes of these alleles are annotated with: spindle; microtubule; spindle microtubule; astral microtubule; spindle pole; S2 cell-line. It has 5 annotated transcripts and 5 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A6-10A6   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Klp10A for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Klp10A-RA FBtr0073475  NM_132459   3498   805 Klp10A-RB FBtr0073478  NM_167267   3579   805 Klp10A-RC FBtr0073479  NM_167268   3669   805 Klp10A-RD FBtr0073477  NM_167269   3393   805 Klp10A-RE FBtr0073476  NM_167270   3238   805
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Klp10A-PA   FBpp0073331   88.7   805   7.23     NP_572687   AAN09282 Klp10A-PB   FBpp0073334   88.7   805   7.23     NP_727491   AAN09283 Klp10A-PC   FBpp0073335   88.7   805   7.23     NP_727492   AAF48003 Klp10A-PD   FBpp0073333   88.7   805   7.23     NP_727493   AAN09284 Klp10A-PE   FBpp0073332   88.7   805   7.23     NP_727494   AAN09285
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0030268
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Kinesin, motor region (IPR001752)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392450   AA438389   AA441043   AA538866   AA540633   AA949737   AA952135   AE003485 AAF48003   AE003485 AAN09282   AE003485 AAN09283   AE003485 AAN09284   AE003485 AAN09285   AI259349   AI388100   AI515258   AI515654   AI532023   AI532286   AI533352   AI534430   AI541585   AI544350   AI546389   AI546390   AI546445   AT01227   AW942943   AX777288   AY051763 AAK93187   BE975372   BF486448   BF487001   BF488015   BF488088   BF488431   BF488520   BF488658   BF489564   BF489668   BF491476   BF491708   BF491744   BF492432   BF492823   BF492824   BF493300   BF493627   BF494375   BF494759   BF495237   BF495560   BF496400   BF497354   BF497441   BF497825   BF498461   BF498964   BF499204   BF499568   BF500733   BF501718   BF502335   BF502367   BF503725   BF503917   BF505411   BF506249   BF506266   BG633040   BG633810   BG634444   BG635172   BG638223   BG639233   BI173294   BI240996   BI242167   BI354473   BI366017   BI372858   BI592847   BI608754   BI609406   BI609578   BI609731   BI609735   BI609874   BI610275   BI632572   BI635599   CK660542   CO186302   CO190139   CO265280   CO268815   CO271864   CO272024   CO272761   CO276530   CO277811   CO278412   CO278451   CO279221   CO280945   CO281647   CO283433   CO284869   CO291851   CO292125   CO293825   CO294534   CO295539   CO300715   CO302843   CO302851   CO305723   CO307536   CO309361   CO316374   CO317609   CO332182   CO335502   CO343511   EC054291   EC061163   EC063004   EC066119   EC071873   EC075029   EC077960   EC078145   EC078697   EC083819   EC084095   EC084274   EC086939   EC088334   EC199462   EC201342   EC205254   EC209809   EC209899   EC212664   EC213253   EC215131   EC217422   EC221364   EC221635   EC222295   EC222417   EC224046   EC232163   EC232182   EC241332   EC243022   EC243049   EC245838   EC246394   EC249290   EC254947   EC267729   EL876746   GH18883   LD47558
UniProtKB/Swiss-Prot	Q960Z0
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	LD29208 (BDGP Project Members, 2000-, Goshima and Vale, 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 2498
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AA952135 AI515654 AI388100
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030268 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0030268 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0030268
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Klp10Af03956 Other Phenotypes Allele mitotic cell cycle defective Klp10AdsRNA.cBa Klp10AdsRNA.cRa Sterility Allele fertile Klp10Af03956 Phenotype manifest in Allele spindle Klp10AMtnA.T:Avic\GFP Klp10AdsRNA.cGa Klp10AdsRNA.cRa spindle microtubule Klp10AdsRNA.cGa astral microtubule Klp10AdsRNA.cGa mitosis & nuclear chromosome Klp10AdsRNA.cGa spindle pole Klp10AdsRNA.cGa S2 cell-line Klp10AdsRNA.cGa microtubule Klp10AdsRNA.cRa
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Klp10A Class Mutagen Stocks Known lesion Klp10Af03956 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Klp10A Class Mutagen Stocks Known lesion Klp10AGD8358 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes Klp10AMtnA.T:Avic\GFP-EGFP in vitro construct | coding region fusion in vitro construct | regulatory fusion 0 Yes Klp10AMtnA.T:Avic\GFP in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes