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Gene Dmel\lva

General Information
Symbol	Dmel\lva	Species	D. melanogaster
Name	lava lamp	Annotation symbol	CG6450
Feature type	protein_coding_gene	FlyBase ID	FBgn0029688
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	4A1-4A1	Sequence location	X:3,849,578..3,858,787 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lava lamp is referred to in FlyBase by the symbol lva (CG6450, FBgn0029688). It has the cytological map location 4A1. Its sequence location is X:3849578..3858787. Its molecular function is described as: actin binding; microtubule binding; protein binding; spectrin binding. It is involved in the biological processes: cellularization; establishment of Golgi localization; negative regulation of dendrite morphogenesis. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4A1-4A1   Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\lva for information on other features
Comments on Gene Model
	DGC clone SD02391 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lva-RC FBtr0070626  NM_080325   8670   2779
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein lva-PC   FBpp0070596   315.9   2779   4.52     NP_525064   AAF45910
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin (IPR009053)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142007   AA698308   AA942044   AE003429 AAF45910   AI403430   AI404494   AI405674   AI519706   AI531383   AW941441   AW944235   AY075374   AY118638 AAM50007   BF487583   BF505983   BG633375   BG638949   BG639512   BG639513   BI574032   BI581324   BI581999   BI582182   BI586343   BI592221   BI605431   BI609784   BI612805   BI617885   BI635037   BI639678   CO300687   CO307016   CO318610   EC051465   EC052413   EC070566   EC073940   EC078334   EC079997   EC079998   EC086952   EC203554   EC206607   EC218545   EC228323   EC238794   EC253924   EY198971   GH25776   LD39389   RH09450   SD01765
UniProtKB/Swiss-Prot	Q8MSS1
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	HL04250 SD02391 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 418
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI519706 AI531383 AI405674
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0029688 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0029688
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4109(2)80 lvadsRNA.1.Scer\UAS neuroanatomy defective, with Scer\GAL4477 lvaDN.Scer\UAS Phenotype manifest in Allele Golgi apparatus & dendritic arborising neuron, with Scer\GAL4477 lvaDN.Scer\UAS dendrite & dendritic arborising neuron, with Scer\GAL4477 lvaDN.Scer\UAS Golgi apparatus & dendritic arborising neuron, with Scer\GAL4109(2)80 lvadsRNA.1.Scer\UAS dendrite & dendritic arborising neuron, with Scer\GAL4109(2)80 lvadsRNA.1.Scer\UAS
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of lva Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lva Class Mutagen Stocks Known lesion lva1.T:Sjap\GST in vitro construct | coding region fusion 0 Yes lva3.T:Sjap\GST in vitro construct | coding region fusion 0 Yes lva5.T:Sjap\GST in vitro construct | coding region fusion 0 Yes lvaDN.Scer\UAS in vitro construct | regulatory fusion 0 Yes lvaGD11929 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes lvadsRNA.1.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes lvadsRNA.2.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)HC244
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11929} NA P{UAS-lva-RNAi.1} NA P{UAS-lva-RNAi.2} NA P{UAS-lva.DN} NA
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 9 )
Molecular Function
CV term Evidence References
actin binding inferred from direct assay (Sisson et al., 2000)
microtubule binding inferred from direct assay (Sisson et al., 2000)
protein binding inferred from physical interaction with FLYBASE:CLIP-190; FB:FBgn0020503 (Sisson et al., 2000)
spectrin binding traceable author statement (Lecuit and Pilot, 2003)
Biological Process
CV term Evidence References
cellularization inferred from mutant phenotype (Papoulas et al., 2005) inferred from mutant phenotype (Sisson et al., 2000) non-traceable author statement (Tepass et al., 2001) traceable author statement (Lecuit and Pilot, 2003)
establishment of Golgi localization inferred from mutant phenotype (Papoulas et al., 2005)
negative regulation of dendrite morphogenesis inferred from mutant phenotype (Ye et al., 2007)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (Sisson et al., 2000) non-traceable author statement (Sisson, 2000.11.4) traceable author statement (Lecuit and Pilot, 2003)
cell cortex inferred from direct assay (Sisson et al., 2000)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lva allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 57868 Drosophila PIMRider - The Drosophila Protein Interaction map • 521866
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21903 Dere\GG18567 Dgri\GH24649 Dpse\GA24315 Dsec\GM12709 Dsim\GD16316 Dvir\GJ15883 Dwil\GK10361 Dyak\GE16878
Curated drosophilid orthologs	Drep\lva   Dsim\lva (Swanson et al., 2001)
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSBTAP00000011669 Bos taurus (Ensembl) ENSMMUP00000017813 Macaca mulatta (Ensembl) ENSRNOP00000042786 Rattus norvegicus (Ensembl) GSTENP00004944001 Tetraodon nigroviridis (Ensembl) ENSXETP00000033610 Xenopus tropicalis (Ensembl) ZDB-GENE-030131-1518 Danio rerio (Zfin) NP_414931.1 Escherichia coliK12 (NCBI)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v40382 w1118; P{GD11929}v40382
Genomic Clones ( 1 )
	BACR21M21
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL04250
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH71028 RH19860 SD01829 GH24235 RH20134 RH09861 RH26273 RH14624 AT22550 AT08327 GH22864 RH48350 LD26054 SD22328 RH41777 RH18702
Other clones	LD39389 EC051465 EK253135 GH25776 RH09450 SD01765 EC052413 EK179118 DMG2-chrX.4.054.a.1 CK00115 EK273211
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0029688 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0029688
Antibody Information
Other Information
Discoverer
Etymology
	Etymology: the gene is named "lava lamp" after the apical/basal movements of Golgi bodies marked with an antibody against the lva protein, which resemble the motion of droplets in a lava lamp. (Sisson et al., 2000)
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: lva CG6450 (Sisson, 2000.11.4)
Source for database merge of
Additional comments
Comments About Role
	lva is required for cellularisation in embryos. (Sisson et al., 2000)
Comments About Molecular Function
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080325 RefSeq (Proteins) • NP_525064 DDBJ / EMBL / GenBank • AA698308 AE003429 AAF45910 AI531383 AW941441 AW944235 AY075374 AY118638 AAM50007 UniProtKB/Swiss-Prot • Q8MSS1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin (IPR009053)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 57868 DEDB - Drosophila exon database: splicing graphs • 418 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0029688 Drosophila PIMRider - The Drosophila Protein Interaction map • 521866 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0029688 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029688 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0029688 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0029688 InParanoid orthologs - Eukaryotic orthologs • ENSBTAP00000011669 Bos taurus (Ensembl) ENSMMUP00000017813 Macaca mulatta (Ensembl) ENSRNOP00000042786 Rattus norvegicus (Ensembl) GSTENP00004944001 Tetraodon nigroviridis (Ensembl) ENSXETP00000033610 Xenopus tropicalis (Ensembl) ZDB-GENE-030131-1518 Danio rerio (Zfin) NP_414931.1 Escherichia coliK12 (NCBI) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/lavalmp1.htm University of Chicago Dev. Expression • FBgn0029688
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	ABP2 (Sisson et al., 2000) CG6450 (Gonzalez et al., 2002, Sisson, 2000.11.4, Quinones-Coello, 2007) CG#6450 (Sisson et al., 2000) lava (Mazumdar and Mazumdar, 2002) Lava (Lu and Bilder, 2005) Lva (Royou et al., 2004, Papoulas et al., 2005, LaLonde et al., 2006, Ataman et al., 2006, Ataman, 2006, Eisman et al., 2006, Papoulas et al., 2005, Jafar-Nejad et al., 2005) LVA (Sisson et al., 2001, Nurminsky, 2007, Monzo et al., 2006) lva (Wang et al., 2007, Quinones-Coello, 2007, Ye et al., 2007, Bakal et al., 2007) lvl (Akbar et al., 2007)
Name Synonym	Lava Lamp (Papoulas et al., 2003, Finger and White, 2002, Papoulas et al., 2005, Sisson et al., 2001, LaLonde et al., 2006, Lu and Bilder, 2005, Eisman et al., 2006, Monzo et al., 2006) lava lamp (Sisson, 2000.11.4, Sisson et al., 2000, Wilhelm et al., 2005) Lava-Lamp (Lu and Bilder, 2005) Lava lamp (Langevin et al., 2005, Papoulas et al., 2005, Lee and Cooley, 2007)
Secondary FlyBase IDs
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 6 ) Review  ( 6 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 6 )
	Lee and Cooley, 2007, J. Cell Biol. 176(7): 941--952 Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. [FBrf0201898] Ye et al., 2007, Cell 130(4): 717--729 Growing dendrites and axons differ in their reliance on the secretory pathway. [FBrf0200877] Ataman et al., 2006, Proc. Natl. Acad. Sci. USA 103(20): 7841--7846 Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. [FBrf0195116] Eisman et al., 2006, J. Cell Sci. 119(Pt 16): 3399--3412 centrosomin's beautiful sister (cbs) encodes a GRIP-domain protein that marks Golgi inheritance and functions in the centrosome cycle in Drosophila. [FBrf0194324] LaLonde et al., 2006, BMC Dev. Biol. 6: A role for Phospholipase D in Drosophila embryonic cellularization. [FBrf0198770] Monzo et al., 2006, Proc. Natl. Acad. Sci. USA 103(48): 18160--18165 Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos. [FBrf0193409] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...