A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Or1a

General Information
SymbolDmel\Or1aSpeciesD. melanogaster
NameOdorant receptor 1aAnnotation symbolCG17885
Feature typeprotein_coding_geneFlyBase IDFBgn0029521
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map1A2-1A2Sequence locationX:209,156..210,590 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Odorant receptor 1a is referred to in FlyBase by the symbol Or1a (CG17885, FBgn0029521). It has the cytological map location 1A2. Its sequence location is X:209156..210590. Its molecular function is described as: olfactory receptor activity; odorant binding. It is involved in the biological processes: olfactory behavior; sensory perception of smell. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
1A2-1A2  
Limits computationally determined from genome sequence between P{EP}CG17896EP1320&P{EP}EP1398 and P{EP}svrEP356&P{EP}argEP452  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Or1a for information on other features
detailed view FBtr0070066 FBtr0070070 FBtr0070102 FBtr0070101 FBtr0273443 FBtr0273442 FBpp0070069 FBpp0271951 FBpp0271950 FBpp0070097 FBpp0070096 FBti0052977
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Or1a-RA
FBtr0070070
 NM_080290
  1179
  392
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Or1a-PA  
FBpp0070069  
45.0  
392  
8.01  
  NP_525029
  AAF45495
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Olfactory receptor, Drosophila (IPR004117)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003417
AAF45495
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of Or1aClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of Or1aClassMutagenStocksKnown lesion
        Or1aGD7082 Yes
        hide Aneuploid Aberrations
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD708}
        NA
        characterization construct
        P{Or1a-Mmus\Cd8a.GFP}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 6 )
        hide Molecular Function
        CV term
        Evidence
        References
        odorant binding
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        olfactory receptor activity
        inferred from sequence or structural similarity
        (Swiss-Prot Project Members, 2000.5.1)
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        hide Biological Process
        CV term
        Evidence
        References
        olfactory behavior
        inferred from mutant phenotype
        (Fishilevich et al., 2005)
        sensory perception of smell
        inferred from sequence or structural similarity
        (Swiss-Prot Project Members, 2000.5.1)
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        hide Cellular Component
        CV term
        Evidence
        References
        integral to membrane
        inferred from sequence or structural similarity
        (Swiss-Prot Project Members, 2000.5.1)
        membrane
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Or1a allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 2 )
        VDRC
        v44184
        w1118; P{GD708}v44184
        v44183
        w1118; P{GD708}v44183/CyO
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 0 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
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        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: Or1a CG17885
        (Warr and Vosshall, 2000.5.19)
        Source for database merge of
        Additional comments
        hide Comments About Role
        Or1a is necessary for larval chemotaxis to the odour (E)-2-hexenal, but is sufficient only in concert with another olfactory sensory neuron.
        (Fishilevich et al., 2005)
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/Swiss-Prot
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Olfactory receptor, Drosophila (IPR004117)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 7 )
        Reported As
        Symbol Synonym
        1a
        (Vogt et al., 2002)
        1A.1
        (Warr and Vosshall, 2000.5.19)
        CG17885
         
        DOR68
        (Warr and Vosshall, 2000.5.19)
        OR1a
        (Stocker, 2006)
        Or1a
         
        Name Synonym
        Odorant receptor 1a
         
        Secondary FlyBase IDs
          hide References ( 15 )
          Research paper
          Fishilevich et al., 2005, Curr. Biol. 15(23): 2086--2096
          Chemotaxis behavior mediated by single larval olfactory neurons in Drosophila. [FBrf0190010]
          Bartolome and Maside, 2004, Genet. Res. 83(2): 91--100
          The lack of recombination drives the fixation of transposable elements on the fourth chromosome of Drosophila melanogaster. [FBrf0179127]
          Vogt et al., 2002, J. exp. Biol. 205(6): 719--744
          A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera). [FBrf0147124]
          Scott et al., 2001, Cell 104(5): 661--673
          A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. [FBrf0134489]
          Vosshall et al., 2000, Cell 102(2): 147--159
          An olfactory sensory map in the fly brain. [FBrf0130146]
          Review
          Stocker, 2006, Curr. Biol. 16(1): 16--18
          [title not yet available] [FBrf0191606]
          Otaki and Yamamoto, 2003, J. Theor. Biol. 223(1): 27--37
          Length analyses of Drosophila odorant receptors. [FBrf0160830]
          Personal communication to FlyBase
          Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
          RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
          FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
          Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
          Robertson, 2001.5.16, FlyBase error report on Wed Mar 16 12:13:50 2001.
          FlyBase error report on Wed Mar 16 12:13:50 2001. [FBrf0136024]
          Warr and Vosshall, 2000.5.19, Odorant receptors.
          Odorant receptors. [FBrf0128191]
          FlyBase analysis
          FlyBase, 1992-, FlyBase curation
          FlyBase curation. [FBrf0105495]
          Protein sequence record
          Swiss-Prot Project Members, 2000.5.1, UniProtKB: Q9W5G6
          PUTATIVE ODORANT RECEPTOR 1A. [FBrf0132010]
          Automatic genome annotation
          FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]
          [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
          Letter
          Warr et al., 2000, Cell 102(2): 145--146
          A unified nomenclature system for the Drosophila odorant receptors. [FBrf0130157]