HomeGene Dmel\Fmr1
| General Information | |||
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| Symbol | Dmel\Fmr1 | Species | D. melanogaster |
| Name | Fmr1 | Annotation symbol | CG6203 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0028734 |
| Created / Updated | 2003-12-01/2003-12-01 | ||
| Genomic Location | |||
| Chromosome (arm) | 3R | Recombination map | |
| Cytogenetic map | 85F10-85F12 | Sequence location | 3R:5,927,136..5,935,844 [-] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | This gene is referred to in FlyBase by the symbol Fmr1 (CG6203, FBgn0028734). It has the cytological map location 85F10-85F12. Its sequence location is 3R:5927136..5935844. Its molecular function is described as: mRNA binding; protein binding. It is involved in the biological processes described with 28 unique terms, many of which group under: anatomical structure development; locomotory behavior; synaptic transmission; regulation of neurogenesis; taxis; circadian rhythm; regulation of metabolic process; regulation of developmental process; central nervous system development; pole cell development; negative regulation of cellular biosynthetic process; locomotion; reproductive process in a multicellular organism; microtubule bundle formation; establishment and/or maintenance of chromatin architecture; cell cycle; oocyte axis determination. 43 alleles are reported. The phenotypes of these alleles are annotated with 34 unique terms, many of which group under: organ system; nervous system; adult segment; peripheral nervous system; adult brain; adult mesothoracic segment; blastoderm embryo; syncytial blastoderm embryo; cleavage stage embryo; thoracic segment. It has 5 annotated transcripts and 5 annotated polypeptides. | ||
| External Summaries | |||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 85F10-85F12
Limits computationally determined from genome sequence between P{lacW}s2681 and P{EP}Fmr1EP3517&P{PZ}tws02414
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 85F9-85F12 (determined by in situ hybridisation)
85F9-85F12 85F12-85F13 | |||
| Experimentally Determined Recombination Data | |||
| Location | |||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Fmr1
for information on other features
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| Comments on Gene Model | |||
DGC clone GH22839 appears problematic: incomplete CDS DGC clone GM08679 appears problematic: contains only 3' UTR sequences EST data support existence of multiple transcripts | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | |||
| Comments | |||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | |||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• K Homology (IPR004087)
K Homology, type 1 (IPR004088)
Nucleic acid-binding, OB-fold (IPR012340)
S1, RNA binding (IPR003029)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References deletion Fmr1[B155] 3R:5,932,666..5,935,166 comment=A 2.5kb portion of the Fmr1 gene, encoding exons 2, 3, and 4, and including the translational start codon and the first 59 codons, has been deleted by imprecise excision of the P{EP} element from Fmr1[EP3422]; position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental deletion Fmr1[1] 3R:5,931,548..5,931,558 comment=An 11bp deletion in the Fmr1[1] allele causes a frame-shift in the N terminus after amino acid 126; position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental point mutation Fmr1[4.L] 3R:5,930,883..5,930,883 comment=Position of mutation on reference sequence inferred by FlyBase curator. evidence=experimental na_change=C5930883T pr_change=Q290|Fmr1-PD,Q252|Fmr1-PE,Q290|Fmr1-PB,Q290 |Fmr1-PA,Q290@|Fmr1-PC reported_na_change=C?T reported_pr_change=Q289@ rescue fragment Fmr1[+t14] 3R:5,925,720..5,939,737 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=BamHI-StuI_rfrag | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
pupal stage,adult stage
neuron
adult stage
adult brain
pupal stage
brain | |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele wild-type (with Df(3R)by62) neuroanatomy defective (with Df(3R)by62) | |||
