Gene Dmel\drpr

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General Information

Symbol

Dmel\drpr

Species

D. melanogaster

Name

draper

Annotation symbol

CG2086

Feature type

protein_coding_gene

FlyBase ID

FBgn0027594

Created / Updated

2003-12-01/2007-03-20

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

62B1-62B1

Sequence location

3L:1,715,594..1,731,093 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene draper is referred to in FlyBase by the symbol drpr (CG2086, FBgn0027594). It has the cytological map location 62B1. Its sequence location is 3L:1715594..1731093. Its molecular function is unknown. It is involved in the biological processes: cell adhesion; larval locomotory behavior; phagocytosis; cell competition in a multicellular organism. 15 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62B1-62B1

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\drpr for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

drpr-RA

FBtr0072798

NM_058102

3193

594

drpr-RB

FBtr0072799

NM_167911

4388

1031

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

drpr-PA

FBpp0072680

66.2

594

6.51

NP_477450

AAF47552

drpr-PB

FBpp0072681

113.0

1031

5.96

NP_728660

AAF47553

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0027594

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

EGF-like, type 3 (IPR000742)

EGF-like, laminin (IPR002049)

Immunoglobulin/major histocompatibility complex, conserved site (IPR003006)

EGF-like (IPR006209)

EGF (IPR006210)

EMI (IPR011489)

EGF-like region, conserved site (IPR013032)

EGF, extracellular (IPR013111)

Growth factor, receptor (IPR009030)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

DS04808

(FlyBase, 1992-)

Does NOT map to

Identified with

GH03529

(BDGP Project Members, 2000-, Manaka et al., 2004)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

2006

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0027594

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0027594

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0027594

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | larval stage, with Scer\GAL4[-]:

drpr^EP522

Other Phenotypes

Allele

locomotor behavior defective | larval stage, with Scer\GAL4[-]:

drpr^EP522

uncoordinated | larval stage, with Scer\GAL4[-]:

drpr^EP522

Phenotype manifest in

Allele

Classical Alleles ( 11 )

For All Classical Alleles Show

Allele of drpr	Class	Mutagen	Stocks	Known lesion
drpr^EP522	hypomorph	P-element activity	2	Yes
drpr^HP20628			1	--
drpr^HP37013			1	--
drpr^c03944		piggyBac transposase	1	--
drpr^c04896		piggyBac transposase	0	--
drpr^e03583		piggyBac transposase	1	--
drpr^f00988		piggyBac transposase	1	--
drpr^f04411		piggyBac transposase	1	--
drpr^f05745		piggyBac transposase	0	--
drpr^Δ19		P-element activity	0	Yes
drpr^Δ5		P-element activity	0	Yes

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of drpr	Mutagen	Stocks	Known lesion
drpr^GD132	in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes
drpr^GD14423	in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
drpr^GD2628	in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
drpr^dsRNA.cMa	in vitro construct \| RNAi	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3L)Mg27

Useful duplication

Dp(3;3)SMG38

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD132}

P{GD14423}

P{GD2628}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{UAST-YFP.RabX1.T19N}Oseg4¹⁴

insertion of mobile activating element

P{EPg}drpr^HP20628

P{EPg}drpr^HP37013

P{EP}drpr^EP522

Related Comments

Please look at the allele reports for the complete phenotype data

drpr is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.

(Li and Baker, 2007)

Gene Ontology: Function, Process & Cellular Component ( 5 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

cell adhesion

inferred from sequence or structural similarity

(FlyBase, 1992-)

cell competition in a multicellular organism

inferred from mutant phenotype

(Li and Baker, 2007)

larval locomotory behavior

inferred from mutant phenotype

(Freeman et al., 2003)

phagocytosis

inferred from mutant phenotype

(Manaka et al., 2004)

traceable author statement

(Evans et al., 2003)

Cellular Component

CV term

Evidence

References

intrinsic to membrane

non-traceable author statement

(Manaka et al., 2004)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

drpr allele

Gene

References

drpr^Δ19

Oseg4

(Freeman et al., 2003)

drpr^Δ5

Oseg4

(Freeman et al., 2003)

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

63751

Orthologs

Genome-wide drosophilid orthologs

Dana\GF24971

Dere\GG14570

Dgri\GH15511

Dmoj\GI16787

Dper\GL11918

Dpse\GA23962

Dsec\GM14179

Dsim\GD13447

Dvir\GJ12529

Dwil\GK17064

Dyak\GE20925

Curated drosophilid orthologs

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000028561
Anopheles gambiae (Ensembl)
ENSBTAP00000033957
Bos taurus (Ensembl)
ENSCAFP00000000867
Canis familiaris (Ensembl)
ENSCINP00000004737
Ciona intestinalis (Ensembl)
NEWSINFRUP00000142701
Takifugu rubripes (Ensembl)
ENSGALP00000012336
Gallus gallus (Ensembl)
ENSP00000274473
Homo sapiens (Ensembl)
ENSMMUP00000024780
Macaca mulatta (Ensembl)
ENSMODP00000019625
Monodelphis domestica (Ensembl)
ENSPTRP00000000109
Pan troglodytes (Ensembl)
ENSRNOP00000036049
Rattus norvegicus (Ensembl)
GSTENP00016018001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000011208
Xenopus tropicalis (Ensembl)
WBGene00038099
Caenorhabditis briggsae (Wormbase)
WBGene00013416
Caenorhabditis elegans (Wormbase)
DDB0214840
Dictyostelium discoideum (Dictybase)
MGI:2685177
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 13 )

v4833

w¹¹¹⁸; P{GD2628}v4833

v27086

w¹¹¹⁸; P{GD14423}v27086

v4830

w¹¹¹⁸; P{GD2628}v4830/TM3

v27084

w¹¹¹⁸; P{GD14423}v27084/TM3

Bloomington

21923

w¹¹¹⁸; P{EPg}drpr^HP20628

22010

w¹¹¹⁸; P{EPg}drpr^HP37013

17175

w¹¹¹⁸; P{EP}drpr^EP522 Oseg4^EP522

More stocks available...

Genomic Clones ( 3 )

cDNA Clones ( 53 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones