Gene Dmel\fz4

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General Information

Symbol

Dmel\fz4

Species

D. melanogaster

Name

frizzled 4

Annotation symbol

CG4626

Feature type

protein_coding_gene

FlyBase ID

FBgn0027342

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

6F5-6F5

Sequence location

X:7,000,305..7,004,325 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene frizzled 4 is referred to in FlyBase by the symbol fz4 (CG4626, FBgn0027342). It has the cytological map location 6F5. Its sequence location is X:7000305..7004325. Its molecular function is described as: transmembrane receptor activity; Wnt receptor activity; Wnt-protein binding; non-G-protein coupled 7TM receptor activity; G-protein coupled receptor activity. It is involved in the biological processes: signal transduction; Wnt receptor signaling pathway; establishment and/or maintenance of cell polarity; cell surface receptor linked signal transduction. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

6F5-6F5

Limits computationally determined from genome sequence between P{EP}inx7^EP1641 and P{EP}CG9650^EP1340&P{EP}CG9650^EP1617

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7A-7A

(Xu, 2000.3.2)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\fz4 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

fz4-RA

FBtr0071018

NM_078513

3380

705

fz4-RB

FBtr0071017

NM_167119

3645

705

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

fz4-PA

FBpp0070977

77.5

705

8.22

NP_511068

AAN09202

fz4-PB

FBpp0070976

77.5

705

8.22

NP_727170

AAF46245

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0027342

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Frizzled cysteine-rich domain (IPR000024)

Frizzled protein (IPR000539)

GPCR, family 2, secretin-like (IPR000832)

Frizzled related (IPR015526)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9NBW1

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

LD28410

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AA949559

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0027342

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0027342

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0027342

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of fz4	Class	Mutagen	Stocks	Known lesion
fz4^GS7412			0	Yes
fz4^GS7425			0	Yes

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of fz4	Class	Mutagen	Stocks	Known lesion
fz4^GD3269		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes

Aneuploid Aberrations

Useful deficiency

Df(1)HA32

Useful duplication

Dp(1;1)GH65

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD3269}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}KG02367

insertion of mobile activating element

P{GSV2}fz4^GS7412

P{GSV2}fz4^GS7425

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 11 )

Molecular Function

CV term

Evidence

References

G-protein coupled receptor activity

inferred from electronic annotation with InterPro:IPR000832

(FlyBase Curators et al., 2004-)

Wnt receptor activity

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

Wnt-protein binding

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 2002.3.1)

non-G-protein coupled 7TM receptor activity

inferred from electronic annotation with InterPro:IPR000539

(FlyBase Curators et al., 2004-)

transmembrane receptor activity

inferred from sequence or structural similarity with FLYBASE:fz; FB:FBgn0001085

(Brody and Cravchik, 2000)

Biological Process

CV term

Evidence

References

Wnt receptor signaling pathway

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 2002.3.1)

non-traceable author statement

(Xu, 2000.3.2)

cell surface receptor linked signal transduction

inferred from electronic annotation with InterPro:IPR000539

(FlyBase Curators et al., 2004-)

establishment and/or maintenance of cell polarity

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 2002.3.1)

signal transduction

inferred from sequence or structural similarity with FLYBASE:fz; FB:FBgn0001085

(Brody and Cravchik, 2000)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from sequence or structural similarity with FLYBASE:fz; FB:FBgn0001085

(Brody and Cravchik, 2000)

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

plasma membrane

inferred from electronic annotation

(Roth and Foulger, 2002.4.24)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

fz4 allele

Gene

References

unspecified

pbl

(Gregory et al., 2007)

Nsf2

(Laviolette et al., 2005)

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

58135

Orthologs

Genome-wide drosophilid orthologs

Dana\GF20940

Dere\GG17634

Dgri\GH24301

Dmoj\GI11047

Dper\GL14637

Dpse\GA18313

Dsec\GM17477

Dsim\GD16161

Dvir\GJ17044

Dwil\GK25820

Dyak\GE17540

Curated drosophilid orthologs

Dpse\GA18313

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000013910
Anopheles gambiae (Ensembl)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

Bloomington

13934

y¹ P{SUPor-P}KG02367

VDRC

v5451

w¹¹¹⁸; P{GD3269}v5451

Genomic Clones ( 2 )

cDNA Clones ( 8 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD28410

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0027342

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0027342

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: fz4 CG4626 Source for merge of fz4 CG4626 was sequence comparison (date:000721). Source for merge of: fz4 anon-WO0170980.10 anon-WO0170980.11 Source for merge of fz4 anon-WO0170980.10 anon-WO0170980.11 was sequence comparison (date:051113).

(FlyBase, 1996-)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

Q9NBW1

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Frizzled cysteine-rich domain (IPR000024)

Frizzled protein (IPR000539)

GPCR, family 2, secretin-like (IPR000832)

Frizzled related (IPR015526)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

58135

DEDB - Drosophila exon database: splicing graphs

•

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0027342

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0027342

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0027342

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0027342

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0027342

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0027342

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000013910
Anopheles gambiae (Ensembl)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0027342

University of Chicago Dev. Expression

•

FBgn0027342

Synonyms & Secondary IDs ( 7 )

Reported As

Symbol Synonym

anon-WO0170980.10

anon-WO0170980.11

CG4626

(Brody and Cravchik, 2000, Laviolette et al., 2005, Alekseyenko et al., 2006, Legube et al., 2006)

DFz4

(Wu and Nusse, 2002, Janson et al., 2001)

fz4

(DasGupta et al., 2005, Furlong, 2005, Laviolette et al., 2005, Bartscherer et al., 2006, Alekseyenko et al., 2006, Gregory et al., 2007)

Name Synonym

frizzled 4

(Xu, 2000.3.2)

Frizzled 4

(McElwain et al., 2007)

Secondary FlyBase IDs

FBgn0029938
FBgn0046616
FBgn0046624

References ( 26 )

Generate a list of

All references relating to this gene ( 26 )

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Recent research papers ( 4 )

Gregory et al., 2007, Fly 1(1): 13--22: A Drosophila Overexpression Screen for Modifiers of Rho Signalling in Cytokinesis. [FBrf0199094]
Alekseyenko et al., 2006, Genes Dev. 20(7): 848--857: High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome. [FBrf0190534]
Bartscherer et al., 2006, Cell 125(3): 523--533: Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. [FBrf0189899]
Legube et al., 2006, Genes Dev. 20(7): 871--883: X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. [FBrf0190549]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2006

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