Gene Dmel\tacc

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General Information

Symbol

Dmel\tacc

Species

D. melanogaster

Name

transforming acidic coiled-coil protein

Annotation symbol

CG9765

Feature type

protein_coding_gene

FlyBase ID

FBgn0026620

Created / Updated

2003-12-22/2003-12-22

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

82D2-82D2

Sequence location

3R:560,132..574,777 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene transforming acidic coiled-coil protein is referred to in FlyBase by the symbol tacc (CG9765, FBgn0026620). It has the cytological map location 82D2. Its sequence location is 3R:560132..574777. Its molecular function is described as: microtubule binding; protein binding. It is involved in the biological processes: negative regulation of microtubule depolymerization; microtubule cytoskeleton organization and biogenesis; mitosis; nuclear migration; pronuclear migration; female meiosis; mitotic spindle organization and biogenesis; pronuclear fusion; protein localization. 18 alleles are reported. The phenotypes of these alleles are annotated with: spindle; aster; mitotic cell cycle; microtubule; pericentriolar material; centrosome; pronucleus; astral microtubule. It has 7 annotated transcripts and 7 annotated polypeptides.

External Summaries

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82D2-82D2

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

82D-82D

(Kramer, 1999.4.29)

82C-82C

(Raff, 1999.4.29)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\tacc for information on other features

Comments on Gene Model

EST data support existence of multiple transcripts

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

tacc-RA

FBtr0089955

NM_058086

4590

1226

tacc-RB

FBtr0089954

NM_169016

4482

1190

tacc-RC

FBtr0089953

NM_058085

4908

1308

tacc-RD

FBtr0089952

NM_176401

4863

1293

tacc-RE

FBtr0089949

NM_176402

1757

245

tacc-RF

FBtr0089951

NM_176403

1794

245

tacc-RG

FBtr0089950

NM_176404

1836

245

Additional Transcript Data & Comments

Reported size (kB)

4.626 (longest cDNA)

(Gergely et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

tacc-PA

FBpp0088894

136.6

1226

4.67

NP_477434

AAN13287

tacc-PB

FBpp0088893

132.4

1190

4.66

NP_730867

AAF52099

tacc-PC

FBpp0088892

145.6

1308

4.64

NP_477433

AAN13288

tacc-PD

FBpp0088891

144.0

1293

4.66

NP_788578

AAO41502

tacc-PE

FBpp0088888

28.6

245

5.34

NP_788579

AAO41503

tacc-PF

FBpp0088890

28.6

245

5.34

NP_788580

AAO41504

tacc-PG

FBpp0088889

28.6

245

5.34

NP_788581

AAO41505

Additional Polypeptide Data & Comments

Reported size (kD)

1190 (aa); 220 (kD observed)

(Gergely et al., 2000)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026620

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Transforming acidic coiled-coil-containing (IPR007707)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

FBcl0297978

(FlyBase, 1992-)

Does NOT map to

Identified with

LD15470

(BDGP Project Members, 2000-, Mukai et al., 2006)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

6374

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

embryonic stage

(Giet et al., 2002)

embryonic stage

whole organism

(Gergely et al., 2000)

embryonic stage

(Giet et al., 2002)

embryonic stage

whole organism

(Gergely et al., 2000)

Marker for

Subcellular Localization

CV Term

centrosome ; GO:0005813

(Gergely et al., 2000)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026620

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0026620

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026620

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | embryonic stage

tacc^stella592

lethal | embryonic stage, with Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}

tacc^{TD.Scer\UAS.P\T.T:Sjap\GST}

Other Phenotypes

Allele

wild-type

mitotic cell cycle defective

tacc^stella592

Sterility

Allele

female sterile

tacc¹

Phenotype manifest in

Allele

mitotic cell cycle

tacc¹

spindle

nucleus & embryo

tacc¹

microtubule

tacc¹

pericentriolar material

tacc¹

centrosome

tacc¹

pronucleus

tacc¹

aster

oocyte & spindle (with Df(3R)110)

tacc¹

centrosome | ectopic

tacc^stella592

astral microtubule

tacc^{S863L.Ubi-p63E.T:Avic\GFP}

Classical Alleles ( 11 )

For All Classical Alleles Show

Allele of tacc	Mutagen	Stocks	Known lesion
tacc¹	ethyl methanesulfonate	0	--
tacc^EP341	P-element activity	1	--
tacc^EY08225	P-element activity	1	--
tacc^d03702	P-element activity	0	--
tacc^d04158	P-element activity	1	--
tacc^d04348	P-element activity	0	--
tacc^d10872	P-element activity	1	--
tacc^f01914	piggyBac transposase	1	--
tacc^f03149	piggyBac transposase	0	--
tacc^f05899	piggyBac transposase	1	--
tacc^stella592	P-element activity	0	--

Alleles Carried on Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Allele of tacc	Mutagen	Stocks	Known lesion
tacc^GD14304	in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes
tacc^{S863L.Ubi-p63E.T:Avic\GFP}	in vitro construct \| amino acid replacement	0	Yes
tacc^{TD.Scer\UAS.P\T.T:Sjap\GST}	in vitro construct \| regulatory fusion in vitro construct \| coding region fusion	0	Yes
tacc^Ubi-p63E.PG	in vitro construct \| regulatory fusion	0	Yes
tacc^{Ubi-p63E.T:Avic\GFP-m6}	in vitro construct \| regulatory fusion	1	Yes
tacc^{Ubi-p63E.T:Avic\GFP}	in vitro construct \| regulatory fusion in vitro construct \| coding region fusion	0	Yes
tacc^{Ubi-p63E.T:Sjap\GST}	in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)110

Useful duplication

Dp(3;3)81-83

Disrupted in

Df(3R)110

(Gergely et al., 2000)

Df(3R)Exel6142

(Ryder, 2004.4.26)

Df(3R)ME15

(Gergely et al., 2000)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct