Gene Dmel\CG8290

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General Information

Symbol

Dmel\CG8290

Species

D. melanogaster

Name

CG8290

Annotation symbol

CG8290

Feature type

protein_coding_gene

FlyBase ID

FBgn0026573

Created / Updated

2003-12-02/2003-12-02

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

48D5-48D5

Sequence location

2R:7,858,179..7,865,236 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG8290 (FBgn0026573). It has the cytological map location 48D5. Its sequence location is 2R:7858179..7865236. Its molecular function is described as: general RNA polymerase II transcription factor activity; zinc ion binding. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

48D5-48D5

Limits computationally determined from genome sequence between P{lacW}l(2)k06612^k06612 and P{lacW}jeb^k05644

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG8290 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG8290-RA

FBtr0088042

NM_165856

4563

1199

CG8290-RB

FBtr0088041

NM_136872

3817

1125

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG8290-PA

FBpp0087148

130.9

1199

5.08

NP_725094

AAF58601

CG8290-PB

FBpp0087147

127.4

1125

8.33

NP_610716

AAM68703

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026573

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

MADF (IPR006578)

Zinc finger, FYVE/PHD-type (IPR011011)

Zinc finger, RING/FYVE/PHD-type (IPR013083)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

(BDGP Project Members, 2000-)

LD29214

(Toba et al., 1999)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

12900

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI457081

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026573

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026573

BDGP expression data

•

Show all BDGP original images, annotations and embryonic microarray data for BEST:LD29214

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for CG8290

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal, with Scer\GAL4^dpp.blk1

CG8290^GS2121

lethal, with Scer\GAL4^c355

CG8290^GS2121

lethal, with Scer\GAL4^hs.2sev

CG8290^GS2121

lethal, with Scer\GAL4^29BD

CG8290^GS2121

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG8290	Class	Mutagen	Stocks	Known lesion
CG8290^GS2121		Δ2-3	1	Yes

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG8290	Class	Mutagen	Stocks	Known lesion
CG8290^GD4729		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful duplication

Dp(2;2)Y3b

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD4729}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{GSV1}CG8290^GS2121

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

general RNA polymerase II transcription factor activity

inferred from sequence or structural similarity with UniProtKB:Q61687

(FlyBase, 1992-)

zinc ion binding

inferred from electronic annotation with InterPro:IPR011011

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

nucleus

inferred from sequence or structural similarity with UniProtKB:Q61687

(FlyBase, 1992-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG8290 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62062

Drosophila PIMRider - The Drosophila Protein Interaction map

•

522212

Orthologs

Genome-wide drosophilid orthologs

Dana\GF13108

Dere\GG20232

Dgri\GH21481

Dmoj\GI19959

Dper\GL20096

Dpse\GA20960

Dsec\GM21320

Dsim\GD10828

Dvir\GJ17920

Dwil\GK22052

Dyak\GE12393

Curated drosophilid orthologs

Dpse\GA20960

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000014141
Anopheles gambiae (Ensembl)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

Kyoto

200280

P{GSV1}CG8290^GS2121

VDRC

v12738

w¹¹¹⁸; P{GD4729}v12738

v12739

w¹¹¹⁸; P{GD4729}v12739

Genomic Clones ( 1 )

BACR14L19

cDNA Clones ( 52 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0026573

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0026573

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: BEST:LD29214 CG8290

(Bayraktaroglu, 2000.11.2)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

MADF (IPR006578)

Zinc finger, FYVE/PHD-type (IPR011011)

Zinc finger, RING/FYVE/PHD-type (IPR013083)

Linkouts

BDGP expression data

•

Show all BDGP original images, annotations and embryonic microarray data for BEST:LD29214

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62062

DEDB - Drosophila exon database: splicing graphs

•

12900

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0026573

Drosophila PIMRider - The Drosophila Protein Interaction map

•

522212

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026573

FlyExpress - Embryonic expression images (BDGP data)

•

FBgn0026573

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0026573

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026573

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0026573

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000014141
Anopheles gambiae (Ensembl)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026573

University of Chicago Dev. Expression

•

FBgn0026573

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

BEST:LD29214

CG8290

LD29214

(Toba et al., 1999)

Name Synonym

CG8290

Secondary FlyBase IDs

FBgn0033670

References ( 7 )

Research paper

Toba et al., 1999, Genetics 151(2): 725--737: The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster.