Gene Dmel\Or47b

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General Information

Symbol

Dmel\Or47b

Species

D. melanogaster

Name

Odorant receptor 47b

Annotation symbol

CG13206

Feature type

protein_coding_gene

FlyBase ID

FBgn0026385

Created / Updated

2003-12-02/2003-12-02

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

47F1-47F1

Sequence location

2R:7,207,215..7,208,817 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Odorant receptor 47b is referred to in FlyBase by the symbol Or47b (CG13206, FBgn0026385). It has the cytological map location 47F1. Its sequence location is 2R:7207215..7208817. Its molecular function is described as: olfactory receptor activity; odorant binding. It is involved in the biological process sensory perception of smell. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47F1-47F1

Limits computationally determined from genome sequence between P{lacW}Fpps^k06103&P{lacW}Fpps^k03514 and P{lacW}Tapδ^k17005&P{lacW}k05103

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: CG7741? Fpps? CG7745? nompA- Or47b?

(Chung et al., 2001)

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Or47b for information on other features

Comments on Gene Model

Gene model based on personal communication to FlyBase; Hugh Robertson, 2003.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Or47b-RA

FBtr0088166

NM_078966

1239

412

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Or47b-PA

FBpp0087262

47.9

412

7.02

NP_523690

AAF58667

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026385

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Olfactory receptor, Drosophila (IPR004117)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P81922

UniProtKB/TrEMBL

Maps to

DS00971

(Clyne et al., 1999)

Does NOT map to

Identified with

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

12982

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026385

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0026385

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026385

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Or47b	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Or47b	Class	Mutagen	Stocks	Known lesion
Or47b^GD610		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes
Or47b^{Scer\UAS.T:Hsap\MYC}		in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)stan1

Useful duplication

Dp(2;2)Y3b

Disrupted in

Df(2R)Exel6060

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD610}

P{UAS-Or47b.MYC}

characterization construct

P{Or47b-GAL4.7.467}

P{Or47b-Mmus\Cd8a.GFP}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 5 )

Molecular Function

CV term

Evidence

References

odorant binding

inferred from electronic annotation with InterPro:IPR004117

(FlyBase Curators et al., 2004-)

olfactory receptor activity

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 1999.8.1)

inferred from direct assay

(Hallem and Carlson, 2006)

Biological Process

CV term

Evidence

References

sensory perception of smell

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 1999.8.1)

inferred from electronic annotation with InterPro:IPR004117

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 1999.8.1)

membrane

inferred from electronic annotation with InterPro:IPR004117

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Or47b allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62005

Orthologs

Genome-wide drosophilid orthologs

Dana\GF12408

Dere\GG22666

Dgri\GH19911

Dmoj\GI19867

Dper\GL17344

Dpse\Or47b

Dsec\GM20445

Dsim\GD25913

Dvir\GJ18994

Dwil\GK22104

Dyak\GE13022

Curated drosophilid orthologs

Dpse\Or47b

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

VDRC

v9354

w¹¹¹⁸; P{GD610}v9354

Genomic Clones ( 1 )

BACR29G22

cDNA Clones ( 4 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0026385

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0026385

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: Or47b Or47E.2

(Warr and Vosshall, 2000.5.19)

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_078966

RefSeq (Proteins)

•

NP_523690

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

P81922

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Olfactory receptor, Drosophila (IPR004117)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62005

DEDB - Drosophila exon database: splicing graphs

•

12982

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0026385

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026385

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0026385

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0026385

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026385

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0026385

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026385

Synonyms & Secondary IDs ( 10 )

Reported As

Symbol Synonym

47b

(Vogt et al., 2002)

47E.2

(Warr and Vosshall, 2000.5.19)

CG13206

(Robertson, 2003.6.22, Warr and Vosshall, 2000.5.19, )

DOR25

(Warr and Vosshall, 2000.5.19)

DOR47E.2

(Clyne et al., 1999)

Or47b

(Kyriacou, 2007, Hallem and Carlson, 2006, de Bruyne and Warr, 2006, Berdnik et al., 2006, Komiyama et al., 2004, van der Goes van Naters and Carlson, 2006, Zhang et al., 2006)

OR 47b

(Alenius and Dickson, 2007)

Or47E.2

(Chung et al., 2001, )

Name Synonym

Odorant receptor 47b

Olfactory receptor 47E.2

(Clyne et al., 1999)

Secondary FlyBase IDs

References ( 37 )

Generate a list of

All references relating to this gene ( 37 )

List References by type

Recent research papers ( 3 )

Berdnik et al., 2006, J. Neurosci. 26(13): 3367--3376: Wiring stability of the adult Drosophila olfactory circuit after lesion. [FBrf0191041]
Hallem and Carlson, 2006, Cell 125(1): 143--160: Coding of odors by a receptor repertoire. [FBrf0189911]
Zhang et al., 2006, genesis 44(4): 189--201: Misexpression screen for genes altering the olfactory map in Drosophila. [FBrf0190678]

Show all research papers ...

Recent reviews ( 3 )

Kyriacou, 2007, Nature 446(7135): 502--504: Sex, flies and acetate. [FBrf0200350]
de Bruyne and Warr, 2006, BioEssays 28(1): 23--34: Molecular and cellular organization of insect chemosensory neurons. [FBrf0189797]
van der Goes van Naters and Carlson, 2006, Nature 444(7117): 302--307: Insects as chemosensors of humans and crops. [FBrf0200019]

Show all reviews ...