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Gene Dmel\Traf6

General Information
Symbol	Dmel\Traf6	Species	D. melanogaster
Name	TNF-receptor-associated factor 6	Annotation symbol	CG10961
Feature type	protein_coding_gene	FlyBase ID	FBgn0026318
Created / Updated	2003-12-01/2008-03-13
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7D16-7D16	Sequence location	X:8,048,623..8,051,399 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene TNF-receptor-associated factor 6 is referred to in FlyBase by the symbol Traf6 (CG10961, FBgn0026318). It has the cytological map location 7D16. Its sequence location is X:8048623..8051399. Its molecular function is described as: protein binding; zinc ion binding. It is involved in the biological processes: dorsal closure; defense response; signal transduction; Toll signaling pathway; innate immune response; regulation of I-kappaB kinase/NF-kappaB cascade. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D16-7D16   Limits computationally determined from genome sequence between P{EP}Ubc-E2HEP1303 and P{EP}CG1583EP1516&P{EP}CG1583EP325
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Traf6 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Traf6-RA FBtr0071188  NM_078525   2777   475
Additional Transcript Data & Comments
Reported size (kB)	1.580 (longest cDNA) (Liu et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Traf6-PA   FBpp0071136   53.8   475   7.39     NP_511080   AAF46338
Additional Polypeptide Data & Comments
Reported size (kD)	463 (aa) (Liu et al., 1999)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0026318
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING/FYVE/PHD-type (IPR013083) Zinc finger, RING-type (IPR001841) MATH (IPR002083) TRAF-like (IPR008974) TRAF-type (IPR013322)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202945   AA246649   AA263419   AA440453   AA696148   AA698231   AA816895   AA948885   AE003443 AAF46338   AF079838 AAD47895   AF119793 AAD34345   AI062094   AI134588   AI513089   AI513982   AI516800   AI544174   AY047501 AAK77233   BI163413   BI214201   BI214202   BI240997   BI242830   BI363741   BI373441   BI373961   BI482324   CO283651   CO294119   CO314422   CZ479890   CZ479891   CZ482712   EC073144   EC075309   EC211833   EC220756   EC223882   EC244243   EC248551   EC259906
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9UAC4 Q9W3I9 Q9XYQ9
Maps to
Does NOT map to
Identified with	GH01161 (BDGP Project Members, 2000-) RE19938 (Geuking et al., 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 841
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI062094
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026318 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0026318 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0026318 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Traf6 Stage(s) 1-3 Stage(s) 4-6 Stage(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Traf6ex1 Other Phenotypes Allele immune response defective Traf6ex1 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Traf6 Class Mutagen Stocks Known lesion Traf6EP1516 1 Yes Traf6e02066 piggyBac transposase 1 -- Traf6ex1 amorph Δ2-3 0 Yes Traf6f00233 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Traf6 Class Mutagen Stocks Known lesion Traf61-159.Act5C.T:Ivir\HA1 in vitro construct | deletion 0 Yes Traf61-264.Act5C.T:Ivir\HA1 in vitro construct | deletion 0 Yes Traf61-309.Act5C.T:Ivir\HA1 in vitro construct | deletion 0 Yes Traf6265-463.Act5C.T:Ivir\HA1 in vitro construct | deletion 0 Yes Traf6Act5C.PS in vitro construct | regulatory fusion 0 Yes Traf6Act5C.T:Ivir\HA1 in vitro construct | regulatory fusion 0 Yes Traf6GD7146 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes Traf6Scer\UAS.T:Ivir\HA1 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes Traf6dsRNA.cSa in vitro construct | RNAi 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)HA11
Useful duplication	Dp(1;1)GH65
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Traf6e02066 NA PBac{WH}Traf6f00233 NA insertion of mobile activating element P{EP}GIIIspla2EP1516 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 9 )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with FLYBASE:ECSIT; FB:FBgn0028436 (Kopp et al., 1999)
zinc ion binding inferred from electronic annotation with InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
Toll signaling pathway traceable author statement (Wu and Arron, 2003)
defense response non-traceable author statement (Lemaitre, 2000.12.20)
dorsal closure traceable author statement (Noselli and Agnes, 1999)
innate immune response inferred from mutant phenotype (Cha et al., 2003)
regulation of I-kappaB kinase/NF-kappaB cascade inferred from mutant phenotype (Cha et al., 2003)
signal transduction non-traceable author statement (Lemaitre, 2000.12.20)
Cellular Component
CV term Evidence References
intracellular traceable author statement (Wu and Arron, 2003)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Traf6 allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 58214 Drosophila PIMRider - The Drosophila Protein Interaction map • 521669
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20974 Dere\GG17981 Dgri\GH24860 Dmoj\GI14410 Dper\GL20189 Dpse\GA10670 Dsec\GM11204 Dvir\GJ18758 Dwil\GK19915 Dyak\GE17475
Curated drosophilid orthologs	Dpse\GA10670
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000017658 Anopheles gambiae (Ensembl) ENSBTAP00000029828 Bos taurus (Ensembl) ENSCAFP00000010159 Canis familiaris (Ensembl) NEWSINFRUP00000164634 Takifugu rubripes (Ensembl) ENSGALP00000012873 Gallus gallus (Ensembl) ENSP00000316840 Homo sapiens (Ensembl) ENSMMUP00000024012 Macaca mulatta (Ensembl) ENSMODP00000024756 Monodelphis domestica (Ensembl) ENSPTRP00000006097 Pan troglodytes (Ensembl) ENSRNOP00000006148 Rattus norvegicus (Ensembl) GSTENP00018197001 Tetraodon nigroviridis (Ensembl) ENSXETP00000016445 Xenopus tropicalis (Ensembl) ZDB-CDNA-040425-1393 Danio rerio (Zfin) ZDB-GENE-030131-5735 Danio rerio (Zfin) MGI:108072 Mus musculus (Informatics)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Harvard	- PBac{RB}Traf6e02066 - PBac{WH}Traf6f00233
Szeged	- P{EP}GIIIspla2EP1516
VDRC	v16125 w1118; P{GD7146}v16125 v16126 w1118; P{GD7146}v16126/TM3
Bloomington	17006 w1118 P{EP}GIIIspla2EP1516 Traf6EP1516
Genomic Clones ( 1 )
	BACR39F18
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01161
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE19939 LD47624 GH12093 RE40266 RE48673 LD20081 RE65004 LD15304 LD05639 GH27019 RE02803 RE61440 LD03443 GM05166 LD07215 LD42871 RE37967 RE19938 RE60723 LD27560 HL03982
Other clones	EK206040 EK164009 EK236105
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0026318 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0026318
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: Traf2 CG10961 (Zhang, 1999.11) Source for identity of: Traf6 Traf2 (Leptin et al., 2008.2.11)
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078525 RefSeq (Proteins) • NP_511080 DDBJ / EMBL / GenBank • AE003443 AAF46338 AF079838 AAD47895 AF119793 AAD34345 AI062094 AI513089 AY047501 AAK77233 CZ479890 CZ479891 CZ482712 UniProtKB/TrEMBL • Q9UAC4 Q9W3I9 Q9XYQ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING/FYVE/PHD-type (IPR013083) Zinc finger, RING-type (IPR001841) MATH (IPR002083) TRAF-like (IPR008974) TRAF-type (IPR013322)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 58214 DEDB - Drosophila exon database: splicing graphs • 841 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0026318 Drosophila PIMRider - The Drosophila Protein Interaction map • 521669 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026318 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0026318 FlyExpress - Embryonic expression images (BDGP data) • FBgn0026318 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026318 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0026318 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0026318 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000017658 Anopheles gambiae (Ensembl) ENSBTAP00000029828 Bos taurus (Ensembl) ENSCAFP00000010159 Canis familiaris (Ensembl) NEWSINFRUP00000164634 Takifugu rubripes (Ensembl) ENSGALP00000012873 Gallus gallus (Ensembl) ENSP00000316840 Homo sapiens (Ensembl) ENSMMUP00000024012 Macaca mulatta (Ensembl) ENSMODP00000024756 Monodelphis domestica (Ensembl) ENSPTRP00000006097 Pan troglodytes (Ensembl) ENSRNOP00000006148 Rattus norvegicus (Ensembl) GSTENP00018197001 Tetraodon nigroviridis (Ensembl) ENSXETP00000016445 Xenopus tropicalis (Ensembl) ZDB-CDNA-040425-1393 Danio rerio (Zfin) ZDB-GENE-030131-5735 Danio rerio (Zfin) MGI:108072 Mus musculus (Informatics) PANTHER - Protein classification by function, families, and pathways • FBgn0026318 University of Chicago Dev. Expression • FBgn0026318
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG10961 (Cha et al., 2003) dTRAF2 (Geuking et al., 2005, Wu and Arron, 2003, Leclerc and Reichhart, 2004, Silverman and Maniatis, 2001, Grech et al., 2000) dtraf2 (Dean and Booker, 2001) dTraf2 (Wasserman, 2000) DTRAF2 (Noselli and Agnes, 1999, Liu et al., 1999, Cha et al., 2003, Kim et al., 2006, Avila et al., 2002, Kuranaga and Miura, 2007) dTRAF6 (Grech et al., 2000, Kopp et al., 1999) TRAF (Shen et al., 2001) TRAF2 (Sun et al., 2002, Lemaitre, 2000.12.20, Skolnik, 1999.1.12) Traf2 (Leptin et al., 2008.2.11, Cha et al., 2005) TRAF6 (Sun et al., 2002, Waterhouse et al., 2007) Traf6
Name Synonym	TNF-receptor-associated factor 2   TNF-receptor-associated factor 6
Secondary FlyBase IDs
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 1 ) Review  ( 6 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 3 )