Gene Dmel\Tip60

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General Information

Symbol

Dmel\Tip60

Species

D. melanogaster

Name

Tip60

Annotation symbol

CG6121

Feature type

protein_coding_gene

FlyBase ID

FBgn0026080

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

4A6-4B1

Sequence location

X:4,008,824..4,011,475 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Tip60 (CG6121, FBgn0026080). It has the cytological map location 4A6-4B1. Its sequence location is X:4008824..4011475. Its molecular function is described as: histone acetyltransferase activity; chromatin binding. It is involved in the biological process chromatin assembly or disassembly. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4A6-4B1

Limits computationally determined from genome sequence between P{EP}CG2930^EP1352 and P{EP}EP425

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Tip60 for information on other features

Comments on Gene Model

Stop Codon spans the intron.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Tip60-RA

FBtr0070668

NM_131923

2354

541

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Tip60-PA

FBpp0070636

61.2

541

8.77

NP_572151

AAF45923

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026080

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Chromo domain (IPR000953)

MOZ/SAS-like protein (IPR002717)

Winged helix repressor DNA-binding (IPR011991)

Acyl-CoA N-acyltransferase (IPR016181)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q960X4

Maps to

Does NOT map to

Identified with

LD31064

(BDGP Project Members, 2000-, Qi et al., 2006, Zhu et al., 2007)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026080

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026080

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Tip60^e02395

viable, with Scer\GAL4^Act5C.PI

Tip60^s-s.Scer\UAS

lethal | partially, with Scer\GAL4^how-24B

Tip60^{dsRNA.Z.Scer\UAS}

lethal | pupal stage, with Scer\GAL4^Act5C.PI

Tip60^{dsRNA.Z.Scer\UAS}

lethal, with Scer\GAL4^337Y

Tip60^{dsRNA.Z.Scer\UAS}

cell lethal

Tip60^{dsRNA.Z.Act5C}

Other Phenotypes

Allele

cytokinesis defective

Tip60^{dsRNA.Z.Act5C}

Sterility

Allele

fertile

Tip60^e02395

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of Tip60	Class	Mutagen	Stocks	Known lesion
Tip60^e02395		piggyBac transposase	2	--

Alleles Carried on Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Tip60	Mutagen	Stocks	Known lesion
Tip60^GD11826	in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
Tip60^{MtnA.T:Zzzz\FLAG}	in vitro construct \| regulatory fusion in vitro construct \| coding region fusion	0	Yes
Tip60^{dsRNA.Z.Act5C}	in vitro construct \| regulatory fusion in vitro construct \| RNAi	0	Yes
Tip60^{dsRNA.Z.Scer\UAS}	in vitro construct \| regulatory fusion in vitro construct \| RNAi	0	Yes
Tip60^dsRNA.cKa	in vitro construct \| RNAi	0	Yes
Tip60^s-s.Act5C	in vitro construct \| regulatory fusion	0	Yes
Tip60^s-s.Scer\UAS	in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(1)HC244

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD11826}

P{UAS-Tip60.RNAi.Z}

P{UAS-Tip60.s-s}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{RB}Tip60^e02395

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 5 )

Molecular Function

CV term

Evidence

References

chromatin binding

inferred from electronic annotation with InterPro:IPR000953

(FlyBase Curators et al., 2004-)

histone acetyltransferase activity

inferred from sequence or structural similarity with SGD_LOCUS:ESA1; SGD:S0005770

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

chromatin assembly or disassembly

inferred from electronic annotation with InterPro:IPR000953

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

chromatin

inferred from electronic annotation with InterPro:IPR000953

(FlyBase Curators et al., 2004-)

nucleus

inferred from electronic annotation with InterPro:IPR000953

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Tip60 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

57879

Orthologs

Genome-wide drosophilid orthologs

Dana\GF21492

Dere\EG:EG0007.7

Dgri\GH24817

Dmoj\GI16149

Dpse\GA19369

Dsec\GM12702

Dsim\EG:EG0007.7

Dvir\GJ16425

Dwil\GK17633

Dyak\EG:EG0007.7

Curated drosophilid orthologs

Dere\EG:EG0007.7

Dpse\GA19369

Dsim\EG:EG0007.7

Dyak\EG:EG0007.7

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011653
Anopheles gambiae (Ensembl)
ENSBTAP00000007328
Bos taurus (Ensembl)
ENSCAFP00000019618
Canis familiaris (Ensembl)
ENSCINP00000017195
Ciona intestinalis (Ensembl)
NEWSINFRUP00000165833
Takifugu rubripes (Ensembl)
ENSP00000340330
Homo sapiens (Ensembl)
ENSMMUP00000026085
Macaca mulatta (Ensembl)
ENSMODP00000011971
Monodelphis domestica (Ensembl)
ENSPTRP00000006709
Pan troglodytes (Ensembl)
ENSRNOP00000028110
Rattus norvegicus (Ensembl)
GSTENP00022103001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000044471
Xenopus tropicalis (Ensembl)
Q8L818
Oryza sativa (Gramene)
Q8LI34
Oryza sativa (Gramene)
Q8W513
Oryza sativa (Gramene)
AT5G09740.1
Arabidopsis thaliana (Arabidopsis)
WBGene00038354
Caenorhabditis briggsae (Wormbase)
WBGene00007029
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-050306-10
Danio rerio (Zfin)
ZDB-GENE-050306-10
Danio rerio (Zfin)
DDB0205993
Dictyostelium discoideum (Dictybase)
MGI:1932051
Mus musculus (Informatics)
YOR244W
Saccharomyces cerevisiae (Yeastgenome)
SPAC637.12c
Schizosaccharomyces pombe (Sanger)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Harvard

PBac{RB}Tip60^e02395

VDRC

v22233

w¹¹¹⁸ P{GD11826}v22233

v22231

w¹¹¹⁸; P{GD11826}v22231

Bloomington

18052

w¹¹¹⁸ PBac{RB}Tip60^e02395

Genomic Clones ( 1 )

BACR21I10

cDNA Clones ( 8 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD31064

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RE51831

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0026080

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0026080

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: EG:EG0007.7 CG6121

(Zhao, 1999.11)

Source for identity of: Tip60 CG6121

(Kusch et al., 2004)

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

(Agaisse et al., 2005)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_131923

RefSeq (Proteins)

•

NP_572151

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q960X4

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Chromo domain (IPR000953)

MOZ/SAS-like protein (IPR002717)

Winged helix repressor DNA-binding (IPR011991)

Acyl-CoA N-acyltransferase (IPR016181)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

57879

DEDB - Drosophila exon database: splicing graphs

•

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0026080

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026080

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0026080

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026080

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0026080

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011653
Anopheles gambiae (Ensembl)
ENSBTAP00000007328
Bos taurus (Ensembl)
ENSCAFP00000019618
Canis familiaris (Ensembl)
ENSCINP00000017195
Ciona intestinalis (Ensembl)
NEWSINFRUP00000165833
Takifugu rubripes (Ensembl)
ENSP00000340330
Homo sapiens (Ensembl)
ENSMMUP00000026085
Macaca mulatta (Ensembl)
ENSMODP00000011971
Monodelphis domestica (Ensembl)
ENSPTRP00000006709
Pan troglodytes (Ensembl)
ENSRNOP00000028110
Rattus norvegicus (Ensembl)
GSTENP00022103001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000044471
Xenopus tropicalis (Ensembl)
Q8L818
Oryza sativa (Gramene)
Q8LI34
Oryza sativa (Gramene)
Q8W513
Oryza sativa (Gramene)
AT5G09740.1
Arabidopsis thaliana (Arabidopsis)
WBGene00038354
Caenorhabditis briggsae (Wormbase)
WBGene00007029
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-050306-10
Danio rerio (Zfin)
ZDB-GENE-050306-10
Danio rerio (Zfin)
DDB0205993
Dictyostelium discoideum (Dictybase)
MGI:1932051
Mus musculus (Informatics)
YOR244W
Saccharomyces cerevisiae (Yeastgenome)
SPAC637.12c
Schizosaccharomyces pombe (Sanger)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026080

Synonyms & Secondary IDs ( 11 )

Reported As

Symbol Synonym

CG6121

(Yang, 2004, Agaisse et al., 2005, Kusch et al., 2004, de la Cruz et al., 2005, Brody et al., 2002, Zhu et al., 2007)

DmEG0007.7

(Pannuti and Lucchesi, 2000)

Dmel/TIP60

(Toth and Elefant, 2007, Zhu and Elefant, 2007)

Dmel\TIP60

(Zhu et al., 2007)

dmHAG405

(Pandey et al., 2002)

dTip60

(Agaisse et al., 2005, Kusch et al., 2004, Kusch et al., 2004, Jin, 2005, D and Emerson, 2006)

dTIP60

(Qi et al., 2006)

EG0007.7

(Sanjuan and Marin, 2001, Pilot et al., 2006)

EG:EG0007.7

(Giot et al., 2003, )

Tip60

(Jin, 2005)

Name Synonym

Tat-interactive protein

(D and Emerson, 2006)

Tip60

Secondary FlyBase IDs

References ( 28 )

Generate a list of

All references relating to this gene ( 28 )

List References by type

Recent research papers ( 3 )

Zhu et al., 2007, Genetics 175(3): 1229--1240: The cloning and characterization of the histone acetyltransferase human homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 is essential for multicellular development. [FBrf0200176]
Pilot et al., 2006, Development 133(4): 711--723: Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation. [FBrf0190315]
Qi et al., 2006, Genetics 174(1): 241--251: Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. [FBrf0193464]

Show all research papers ...

Recent reviews ( 3 )

D and Emerson, 2006, Curr. Opin. Genet. Dev. 16(5): 508--512: Remodeling plans for cellular specialization: unique styles for every room. [FBrf0192819]
Polo, 2006, Curr. Opin. Genet. Dev. 16(2): 104--111: [title not yet available] [FBrf0191591]
Raisner, 2006, Curr. Opin. Genet. Dev. 16(2): 119--124: [title not yet available] [FBrf0191593]

Show all reviews ...