Gene Dmel\Eph

General Information
Symbol	Dmel\Eph	Species	D. melanogaster
Name	Eph receptor tyrosine kinase	Annotation symbol	CG1511
Feature type	protein_coding_gene	FlyBase ID	FBgn0025936
Created / Updated	2005-01-19/2005-01-19
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102C2-102C2	Sequence location	4:631,312..641,554 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene Eph receptor tyrosine kinase is referred to in FlyBase by the symbol Eph (CG1511, FBgn0025936). It has the cytological map location 102C2. Its sequence location is 4:631312..641554. Its molecular function is described as: transmembrane receptor protein tyrosine kinase activity; protein-tyrosine kinase activity; ephrin receptor activity; ATP binding. It is involved in the biological processes: protein amino acid phosphorylation; signal transduction; axonogenesis; mushroom body development; transmembrane receptor protein tyrosine kinase signaling pathway. 11 alleles are reported. The phenotypes of these alleles are annotated with: medulla cortex; lobula plate cortex; medulla neuropil; larval optic lobe; commissure; longitudinal connective; embryonic neuron; dorsal lobe; medial lobe. It has 5 annotated transcripts and 5 annotated polypeptides.
External Summaries

Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102C2-102C2 Limits computationally determined from genome sequence between P{SUPor-P}Asator^KG05051&P{SUPor-P}KG01424 and PBac{3HPy⁺}C024
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102C6-102C6 (Scully, 1999.2.28) 102C-102C (He, 1999.4.28)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: Eph- onecut+ (Nguyen et al., 2000)
Gene Model & Products
Please see the GBrowse view of Dmel\Eph for information on other features
Comments on Gene Model
	impossible to make valid gene model that agrees with swissprot real and BLAST sequence
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Eph-RA FBtr0089082 NM_166775 4142 1080 Eph-RB FBtr0089083 NM_166777 4068 1047 Eph-RC FBtr0089084 NM_079886 4190 1096 Eph-RD FBtr0089085 NM_166774 3689 1080 Eph-RE FBtr0089086 NM_166776 4142 1080
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Eph-PA FBpp0088151 121.5 1080 6.77 NP_726589 AAG22122 Eph-PB FBpp0088152 117.9 1047 6.61 NP_726591 AAN06504 Eph-PC FBpp0088153 123.3 1096 6.87 NP_524625 AAF59329 Eph-PD FBpp0088154 121.7 1080 6.77 NP_726588 AAN06502 Eph-PE FBpp0088155 121.5 1080 6.77 NP_726590 AAN06503
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0025936
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, core (IPR000719) Ephrin receptor, ligand binding (IPR001090) Tyrosine protein kinase (IPR001245) Sterile alpha motif SAM (IPR001660) Fibronectin, type III (IPR003961) Tyrosine protein kinase, active site (IPR008266) Fibronectin, type III-like fold (IPR008957) Galactose-binding like (IPR008979) Sterile alpha motif homology (IPR010993) Protein kinase-like (IPR011009) EGF-like region, conserved site (IPR013032) Receptor tyrosine kinase, class V, conserved site (IPR001426) Tyrosine-protein kinase, ephrin receptor (IPR016257) Protein kinase ATP binding, conserved site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202579 AA438323 AA439824 AA538926 AA540090 AA540177 AA698678 AA820775 AE003843 AAF59329 AE003843 AAG22122 AE003843 AAN06502 AE003843 AAN06503 AE003843 AAN06504 AF052730 AAC99308 AF132028 AAD38508 AF146648 AAD30170 AY118403 AAM48432 BG637757 BG638069 BI213604 BI216114 BI236295 BI243044 BI356092 BI357885 BI357892 BI362512 BI372165 BI373680 BI484831 BI580741 BP545383 BP545384 BT021297 AAX33445 CO177607 CO185604 CO186486 CO188889 CO189144 CO189721 CO189919 CO190266 CO190708 CO262242 CO263163 CO263170 CO263462 CO264365 CO265797 CO269802 CO269853 CO273133 CO274939 CO275064 CO275199 CO275873 CO276262 CO276561 CO283384 CO284254 CO284406 CO285889 CO286043 CO286227 CO287884 CO289463 CO290394 CO293755 CO294295 CO294379 CO295780 CO302947 CO304213 CO304323 CO305704 CO306213 CO307129 CO312053 CO313826 CO316848 CO317072 CO317153 CO318718 CO320766 CO322010 CO329621 CO330538 CO331740 CO332636 CO333880 CO342781 CO344086 EC051029 EC052537 EC057131 EC057132 EC057563 EC058442 EC058613 EC060588 EC065313 EC065976 EC070360 EC070723 EC071485 EC071487 EC076433 EC077127 EC078067 EC078972 EC079026 EC079405 EC080735 EC082097 EC082205 EC083419 EC084334 EC088114 EC088703 EC090207 EC090508 EC195962 EC196592 EC196808 EC196817 EC198086 EC199515 EC201553 EC202580 EC203355 EC203457 EC204035 EC204385 EC208949 EC208964 EC211756 EC215544 EC220179 EC221277 EC221884 EC226826 EC227699 EC228071 EC229895 EC230432 EC231311 EC232664 EC234840 EC238589 EC239266 EC240428 EC240708 EC241230 EC241269 EC242655 EC243228 EC243346 EC243513 EC244571 EC246725 EC247321 EC248652 EC251146 EC254875 EC255056 LD02720 LD14495

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96435 Q59DQ4 Q5BIC7 Q8IMC2 Q8MT37 Q9V4E5 Q9XZL6 Q9Y1J0 Q0KIF4

Maps to
Does NOT map to
Identified with	RE23033 RE61046 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 13599
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for

Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025936 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0025936 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0025936
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable \| recessive Eph^x652 Other Phenotypes Allele visible, with Scer\GAL4^ap-md544 Eph^DN.Scer\UAS neuroanatomy defective Eph^dsRNA.cBa Eph^dsRNA.cDa Eph^x652 neuroanatomy defective, with Scer\GAL4^bi-md653 Eph^Scer\UAS.cDa neuroanatomy defective, with Scer\GAL4^ap-md544 Eph^DN.Scer\UAS Eph^Scer\UAS.cDa neuroanatomy defective, with Scer\GAL4^ey.PH Eph^DN.Scer\UAS neuroanatomy defective, with Scer\GAL4^αTub84B.PP Eph^DN.Scer\UAS Sterility Allele fertile \| recessive Eph^x652 Phenotype manifest in Allele medulla cortex, with Scer\GAL4^ey.PH Eph^DN.Scer\UAS lobula plate cortex, with Scer\GAL4^ey.PH Eph^DN.Scer\UAS photoreceptor cell & axon, with Scer\GAL4^ey.PH Eph^DN.Scer\UAS larval optic lobe, with Scer\GAL4^ey.PH Eph^DN.Scer\UAS medulla neuropil, with Scer\GAL4^ey.PH Eph^DN.Scer\UAS medulla cortex, with Scer\GAL4^ap-md544 Eph^DN.Scer\UAS Eph^Scer\UAS.cDa photoreceptor cell R7 & axon \| somatic clone, with Scer\GAL4^αTub84B.PP Eph^DN.Scer\UAS photoreceptor cell R8 & axon \| somatic clone, with Scer\GAL4^αTub84B.PP Eph^DN.Scer\UAS medulla cortex \| somatic clone, with Scer\GAL4^αTub84B.PP Eph^DN.Scer\UAS medulla cortex, with Scer\GAL4^bi-md653 Eph^Scer\UAS.cDa medulla neuropil, with Scer\GAL4^bi-md653 Eph^Scer\UAS.cDa photoreceptor cell & axon, with Scer\GAL4^bi-md653 Eph^Scer\UAS.cDa commissure Eph^dsRNA.cBa longitudinal connective Eph^dsRNA.cBa embryonic neuron Eph^dsRNA.cBa medulla cortex Eph^dsRNA.cDa lobula plate cortex Eph^dsRNA.cDa photoreceptor & axon Eph^dsRNA.cDa