Gene Dmel\TBPH

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General Information

Symbol

Dmel\TBPH

Species

D. melanogaster

Name

TBPH

Annotation symbol

CG10327

Feature type

protein_coding_gene

FlyBase ID

FBgn0025790

Created / Updated

2003-12-22/2003-12-22

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

60A4-60A5

Sequence location

2R:19,746,589..19,750,104 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol TBPH (CG10327, FBgn0025790). It has the cytological map location 60A4-60A5. Its sequence location is 2R:19746589..19750104. Its molecular function is described as: mRNA binding; nucleic acid binding; nucleotide binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A4-60A5

Limits computationally determined from genome sequence between P{lacW}eIF6^k13214 and P{lacW}ken^k11035&P{EP}CG17658^EP730

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60A-60A

(Lukacsovich, 1998.11.11)

60A-60A

(Lukacsovich, 1998.1.8)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: ytr- gbb+ bgcn- wibg- bgcn- TBPH- CG4585- Thiolase- ken+ TM4SF+ CG4882- TM4SF+ CG4882- PHDP-

(Lukacsovich et al., 1999)

In direction of increasing cytology: gbb+ bgcn- gbb+ bgcn- wibg- bgcn- TBPH-

(Ohlstein et al., 2000)

Gene Order (overall orientation not stated)

References

Overall orientation not stated: PHDP+ CG4882+ TM4SF- ken- Thiolase+ CG4585+ TBPH+

(Lukacsovich, 1998.1.8)

Gene Model & Products

Please see the GBrowse view of Dmel\TBPH for information on other features

Comments on Gene Model

Multiphase exon postulated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

TBPH-RA

FBtr0089626

NM_058051

1675

332

TBPH-RB

FBtr0089624

NM_058052

1916

531

TBPH-RC

FBtr0089625

NM_134318

3211

531

TBPH-RD

FBtr0089627

NM_166628

2145

531

Additional Transcript Data & Comments

Reported size (kB)

3.166, 1.916, 1.638 (longest cDNA)

(Lukacsovich et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

TBPH-PA

FBpp0088569

37.7

332

6.42

NP_477399

AAF47080

TBPH-PB

FBpp0088567

58.1

531

7.15

NP_477400

AAF47079

TBPH-PC

FBpp0088568

58.1

531

7.15

NP_599145

AAF47078

TBPH-PD

FBpp0088570

58.1

531

7.15

NP_726373

AAM68274

Additional Polypeptide Data & Comments

Reported size (kD)

531, 332 (aa)

(Lukacsovich et al., 1999)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0025790

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RNA recognition motif, RNP-1 (IPR000504)

Nucleotide-binding, alpha-beta plait (IPR012677)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

DS06185

(FlyBase, 1992-)

Does NOT map to

Identified with

GH09868

(Lukacsovich et al., 1999, BDGP Project Members, 2000-)

(Lukacsovich et al., 1999)

RH39704

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

1549

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

pupal stage

(Lukacsovich et al., 1999)

embryonic stage

(Lukacsovich et al., 1999)

pupal stage

(Lukacsovich et al., 1999)

embryonic stage

(Lukacsovich et al., 1999)

pupal stage

(Lukacsovich et al., 1999)

embryonic stage

(Lukacsovich et al., 1999)

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AA940992
AI113536

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0025790

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0025790

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0025790

BDGP expression data

•

Show all BDGP original images, annotations and embryonic microarray data for TBPH

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for TBPH

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

TBPH^EY10530

Sterility

Allele

fertile

TBPH^EY10530

Phenotype manifest in

Allele

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of TBPH	Class	Mutagen	Stocks	Known lesion
TBPH^EY10530		P-element activity	1	--
TBPH^KG08578		P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of TBPH	Class	Mutagen	Stocks	Known lesion
TBPH^GD17745		in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes
TBPH^GD6943		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)or-BR11

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD17745}

P{GD6943}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}TBPH^KG08578

insertion of mobile activating element

P{EPgy2}TBPH^EY10530

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

nucleic acid binding

inferred from electronic annotation with InterPro:IPR000504

(FlyBase Curators et al., 2004-)

nucleotide binding

inferred from electronic annotation with InterPro:IPR012677

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

TBPH allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

63374

Orthologs

Genome-wide drosophilid orthologs

Dana\GF12452

Dere\GG19989

Dgri\GH20198

Dmoj\GI20724

Dper\GL10927

Dpse\GA10247

Dsec\GM15502

Dsim\GD25005

Dvir\GJ21868

Dwil\GK15864

Dyak\GE11522

Curated drosophilid orthologs

Dpse\GA10247

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000019748
Anopheles gambiae (Ensembl)
ENSBTAP00000004816
Bos taurus (Ensembl)
ENSCAFP00000024639
Canis familiaris (Ensembl)
ENSCINP00000000073
Ciona intestinalis (Ensembl)
NEWSINFRUP00000146060
Takifugu rubripes (Ensembl)
ENSGALP00000004576
Gallus gallus (Ensembl)
ENSP00000240185
Homo sapiens (Ensembl)
ENSMMUP00000009781
Macaca mulatta (Ensembl)
ENSMODP00000014059
Monodelphis domestica (Ensembl)
ENSPTRP00000000267
Pan troglodytes (Ensembl)
ENSRNOP00000017278
Rattus norvegicus (Ensembl)
GSTENP00028242001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000013850
Xenopus tropicalis (Ensembl)
WBGene00026137
Caenorhabditis briggsae (Wormbase)
WBGene00006514
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-040425-903
Danio rerio (Zfin)
ZDB-GENE-030131-3777
Danio rerio (Zfin)
MGI:2387629
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

VDRC

v38377

w¹¹¹⁸; P{GD6943}v38377

v38379

w¹¹¹⁸; P{GD6943}v38379

Bloomington

20801

y¹ w^67c23; P{EPgy2}TBPH^EY10530

14737

y¹ w^67c23; P{SUPor-P}TBPH^KG08578

Genomic Clones ( 1 )

BACR05F24

cDNA Clones ( 24 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones