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Gene Dmel\skpA

General Information
Symbol	Dmel\skpA	Species	D. melanogaster
Name	skpA	Annotation symbol	CG16983
Feature type	protein_coding_gene	FlyBase ID	FBgn0025637
Created / Updated	2005-09-09/2005-09-09
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	1B14-1B14	Sequence location	X:550,105..551,937 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol skpA (CG16983, FBgn0025637). It has the cytological map location 1B14. Its sequence location is X:550105..551937. Its molecular function is described as protein binding. It is involved in the biological processes: DNA endoreduplication; centrosome duplication; chromosome condensation; positive regulation of mitotic cell cycle; ubiquitin-dependent protein catabolic process. 19 alleles are reported. The phenotypes of these alleles are annotated with: melanotic mass; larval digestive system; imaginal disc; larval central nervous system; centrosome; chromatin. It has 8 annotated transcripts and 8 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1B14-1B14   Limits computationally determined from genome sequence between P{EP}DreddEP1412&P{EP}Suv4-20EP1216a and P{EP}sdkEP369
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1C1-1C2 (determined by in situ hybridisation) 1C (determined by in situ hybridisation) 1B7--8 (determined by in situ hybridisation)   (Peter et al., 2002) 1B13-1B13   (Murphy, 1999.12.29) 1C-1C (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 1C-1C (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 1C1-1C2 (determined by in situ hybridisation) 1B7--8 (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\skpA for information on other features
Comments on Gene Model
	transcript symbols matched to SEAN transcripts for 5' splice site. Transcription start not always the same. EST data suggest that multiple transcription start sites are used.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) skpA-RA FBtr0070123  NM_058042   1134   162 skpA-RB FBtr0070126  NM_166856   938   162 skpA-RC FBtr0070127  NM_166857   1035   162 skpA-RD FBtr0070124  NM_166858   1519   162 skpA-RE FBtr0070129  NM_166859   851   162 skpA-RF FBtr0070128  NM_166860   913   162 skpA-RG FBtr0070125  NM_166861   860   162 skpA-RH FBtr0100530  NM_001038729   1512   162
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein skpA-PA   FBpp0070118   18.6   162   4.27     NP_477390   AAF45538 skpA-PB   FBpp0070121   18.6   162   4.27     NP_726690   AAF45539 skpA-PC   FBpp0070122   18.6   162   4.27     NP_726691   AAN09024 skpA-PD   FBpp0070119   18.6   162   4.27     NP_726692   AAG22362 skpA-PE   FBpp0070124   18.6   162   4.27     NP_726693   AAN09025 skpA-PF   FBpp0070123   18.6   162   4.27     NP_726694   AAF45540 skpA-PG   FBpp0070120   18.6   162   4.27     NP_726695   AAN09026 skpA-PH   FBpp0099971   18.6   162   4.27     NP_001033818   ABC67161
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0025637
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) SKP1 component (IPR001232) SKP1 component, dimerisation (IPR016072) SKP1 component, POZ (IPR016073) E3 ubiquitin ligase, SCF complex, Skp subunit (IPR016897)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202191   AA263880   AA438321   AA438564   AA438567   AA539929   AA539972   AA568082   AA816658   AA950092   AE003418 AAF45538   AE003418 AAF45539   AE003418 AAF45540   AE003418 AAG22362   AE003418 AAN09024   AE003418 AAN09025   AE003418 AAN09026   AF220066 AAF64674   AI258778   AI295296   AI295799   AI519069   AI520497   AI533767   AI947189   AJ299998   AJ300000   AQ025456   AW941992   AX777380   AX777382   AX777384   AY069297 AAL39442   BG636256   BG637770   BI161852   BI161853   BI164607   BI166714   BI168898   BI169453   BI171516   BI172193   BI173336   BI173907   BI212854   BI212937   BI213148   BI215299   BI215520   BI230041   BI232907   BI235238   BI235516   BI236123   BI237305   BI237413   BI237652   BI239369   BI240075   BI242000   BI242693   BI243513   BI356295   BI363238   BI363492   BI364740   BI364874   BI367268   BI370709   BI371891   BI375916   BI482931   BI486146   BI486625   BI564140   BI578177   BI579047   BI580281   BI580335   BI580461   BI586731   BI586904   BI586906   BI614750   BI618007   BI627235   BI634941   BI635050   BI635638   BI636135   BI636916   BI638538   BI641366   BI641622   BP543368   BP543369   BP543477   BP543478   BP543717   BP543718   BP548242   BP548316   BP549787   BP549788   BP550494   BP555241   BP555242   BP559228   BP559229   CO180490   CO181210   CO183953   CO184246   CO314959   CO318260   CO322028   CO329511   EC058895   EC074425   EC076886   EC089206   EC090211   EC204571   EC204572   EC208112   EC223156   EC230743   EC237453   EC250094   LD03188   RE01337
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O77430
Maps to	115C2 (FlyBase, 1992-, Murphy, 1999.3.10) BAC09A14 (Murphy, 2003)
Does NOT map to
Identified with	bs36b04 LP09540 (Oliver, 2001.8.16) HL01263 (BDGP Project Members, 2000-) LD03188 (Benos et al., 2001) LD07173 (Das et al., 2002) LP02056 (Bocca et al., 2001)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation skpA[J6] X:551,435..551,435 evidence=experimental na_change=C551435T pr_change=T98I|skpA-PE,T98I|skpA-PF,T98I|skpA-PC,T98I|sk pA-PB,T98I|skpA-PG,T98I|skpA-PD,T98I|skpA-PA,T98I|skpA-PH reported_na_change=C3087T reported_pr_change=T98I (Khush et al., 2002) point mutation skpA[G49] X:551,443..551,443 evidence=experimental na_change=G551443A pr_change=E101K|skpA-PE,E101K|skpA-PF,E101K|skpA-PC,E101 K|skpA-PB,E101K|skpA-PG,E101K|skpA-PD,E101K|skpA-PA,E101K| skpA-PH reported_na_change=G3095A reported_pr_change=E101K (Khush et al., 2002) rescue fragment skpA[+t4] X:548,349..552,276 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=HindIII-HindIII_rfrag (Murphy, 2003)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 90
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025637 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0025637 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0025637
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable skpAG49 skpAJ6 lethal | recessive skpAG0037 skpAG0058 skpAG0109 skpAG0389 skpAPG49 lethal | larval stage skpAG0037 skpAG0058 skpAG0109 skpAG0389 lethal | larval stage | recessive skpA1 skpA2 skpA3 skpA4 lethal | prepupal stage skpAG0037 lethal | pupal stage skpAG0037 lethal | pupal stage | conditional - heat sensitive skpAG49 lethal | pharate adult stage skpAG0037 Other Phenotypes Allele mitotic cell cycle defective skpA1 melanotic 'tumor' | larval stage skpAG0037 Sterility Allele fertile skpAG49 skpAJ6 Phenotype manifest in Allele imaginal disc skpA1 larval central nervous system skpA1 centrosome | supernumerary skpA1 chromatin skpA1 larval fat body & nucleus skpA1 larval foregut & nucleus skpA1 larval midgut & nucleus skpA1 larval hindgut & nucleus skpA1 melanotic mass skpAG0037 skpAG0389 larval digestive system skpAG0389
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of skpA Class Mutagen Stocks Known lesion skpA1 loss of function Δ2-3 1 Yes skpAEP1216a P-element activity 0 Yes skpAEP1423 P-element activity 2 Yes skpAG0037 P-element activity 1 -- skpAG0058 P-element activity 1 -- skpA