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Gene Dmel\stan

General Information
Symbol	Dmel\stan	Species	D. melanogaster
Name	starry night	Annotation symbol	CG11895
Feature type	protein_coding_gene	FlyBase ID	FBgn0024836
Created / Updated	2005-01-19/2005-01-19
Genomic Location
Chromosome (arm)	2R	Recombination map	2-62
Cytogenetic map	47B6-47B7	Sequence location	2R:6,593,411..6,608,646 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene starry night is referred to in FlyBase by the symbol stan (CG11895, FBgn0024836). It has the cytological map location 47B6-47B7. Its sequence location is 2R:6593411..6608646. Its molecular function is described as: G-protein coupled receptor activity; receptor signaling protein activity; cell adhesion molecule binding; receptor activity; transmembrane receptor activity; calcium ion binding. It is involved in the biological processes described with 19 unique terms, many of which group under: anatomical structure development; sensory organ development; cell projection organization and biogenesis; establishment of planar polarity; cell adhesion; neuron differentiation; regulation of Wnt receptor signaling pathway; cell communication; cell-cell adhesion; homophilic cell adhesion; calcium-dependent cell-cell adhesion; embryonic pattern specification; positive regulation of signal transduction; ommatidial rotation; G-protein coupled receptor protein signaling pathway; regulation of biological process. 28 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: nervous system; peripheral nervous system; organ system; adult segment; embryonic nervous system; adult brain; adult mesothoracic segment; thoracic segment; embryonic neuron; wing hair; adult. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47B6-47B7   Limits computationally determined from genome sequence between P{PZ}lola00349&P{EP}lolaEP952 and P{lacW}l(2)k00909k00909&P{EP}EP2619EP2619
Experimentally Determined Cytological Location
Cytogenetic map Notes References 47B2-47B4   (Chae, 1999.7.26) 47A-47B Determined by deficiency mapping (details unspecified).   (Gao et al., 1999) 47B3-47B5   (Chae et al., 1999) 47B-47B (determined by in situ hybridisation)   (Usui et al., 1999) 47B-47B   (Uemura, 1999.3.3) 47B2-47B4   (Chae et al., 1999)
Experimentally Determined Recombination Data
Location	2-62 (Chae et al., 1999)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: anon-47Ba? stan+ Rab3? (Chae et al., 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\stan for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) stan-RA FBtr0088214  NM_165794   12642   3579
Additional Transcript Data & Comments
Reported size (kB)	>12 (northern blot) (Chae et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein stan-PA   FBpp0087309   397.1   3579   5.16     NP_724962   AAF58763
Additional Polypeptide Data & Comments
Reported size (kD)	3579 (aa) (Chae et al., 1999)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0024836
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cadherin-like (IPR015919) GPS (IPR000203) EGF-like, type 3 (IPR000742) GPCR, family 2, secretin-like (IPR000832) Laminin G (IPR001791) GPCR, family 2, extracellular region (IPR001879) EGF-like calcium-binding (IPR001881) EGF-like, laminin (IPR002049) Cadherin (IPR002126) EGF-like (IPR006209) EGF (IPR006210) Concanavalin A-like lectin/glucanase (IPR008985) Laminin G, subdomain 2 (IPR012680) EGF-like region, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AB028498 BAA84069   AE003828 AAF58763   AF172329 AAF02618   CG11895   CO270333   CO302196   CO308699   CO322655   CO324348   CO326920   CO327258   CO327679   CO328504   CZ483387   CZ483388   DQ017444   DQ017445   EC062833   EC076732   EC077729   EC200596   EC215457   EC220137   EC232677   EC233755   EC235225   EC235373   EC258007   EC259951   EL871067   EL871068   EL871182   EL871183   EL871304   EL871305   EL871421   EL871422
UniProtKB/Swiss-Prot	Q9V5N8
UniProtKB/TrEMBL
Maps to	DS06673 DS07000 (Chae et al., 1999)
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation stan[51] 2R:6,598,281..6,598,281 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C6598281T pr_change=Q1393@|stan-PA reported_pr_change=?1393@ point mutation stan[6] 2R:6,598,495..6,598,495 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G6598495A pr_change=C1464Y|stan-PA reported_pr_change=C1464Y (Sweeney et al., 2002) point mutation stan[E59] 2R:6,599,613..6,599,613 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C6599613T pr_change=Q1837@|stan-PA reported_pr_change=Q1838@ (Usui et al., 1999) point mutation stan[E45] 2R:6,599,647..6,599,647 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6599647A pr_change=V1848D|stan-PA reported_pr_change=V1849D (Usui et al., 1999) point mutation stan[72] 2R:6,601,131..6,601,131 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C6601131T pr_change=R2343@|stan-PA reported_pr_change=?2343@ (Sweeney et al., 2002)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 13035
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage-pupal stage   (Chae et al., 1999)  pupal stage  wing (Chae et al., 1999)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  larval stage | third instar  lamina & neuron (Senti et al., 2003)  larval stage | third instar  photoreceptor cell & growth cone (Senti et al., 2003)  pupal stage | early  ovarian sheath cell (Cohen et al., 2002)  larval stage | third instar  medulla & neuron (Senti et al., 2003)  pupal stage  medulla & neuron (Senti et al., 2003)  pupal stage  lamina & neuron (Senti et al., 2003)
Marker for
Subcellular Localization
CV Term	plasma membrane (Chae et al., 1999)
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024836 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0024836 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0024836
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable stan3 stanf00907 viable, with Scer\GAL4ptc-559.1 stanScer\UAS.cUa lethal | recessive stan21 stanVC31 lethal | embryonic stage | recessive stanE45 stanE59 lethal | pupal stage, with Scer\GAL4αTub84B.PL stanScer\UAS.cUa Other Phenotypes Allele visible (with stanE59), with Scer\GAL41407, stanScer\UAS.cUa stanE45 visible (with stanE45), with Scer\GAL41407, stanScer\UAS.cUa stanE59 visible | cell autonomous | recessive | somatic clone stanE59 visible, with Scer\GAL41407, stanE45/stanE59 stanScer\UAS.cUa visible, with Scer\GAL4ptc-559.1 stanScer\UAS.cUa visible, with Scer\GAL4bi-md653 stanScer\UAS.cUa reduced cell number | somatic clone stanE59 stanMB cell polarity defective | somatic clone stanE59 neuroanatomy defective stan6 stan72 stanE59 neuroanatomy defective | somatic clone stan72 stanE59 stanMB neuroanatomy defective | somatic clone, with standsRNA.intra.Scer\UAS standsRNA.extra.Scer\UAS neuroanatomy defective | somatic clone, with standsRNA.extra.Scer\UAS standsRNA.intra.Scer\UAS neuroanatomy defective, with Scer\GAL4OK107 stanScer\UAS.cUa tissue polarity defective stan192 stan20 stan71 stanfrz3 tissue polarity defective | cell autonomous stanE59 tissue polarity defective | cell autonomous | recessive | somatic clone stan21 stan24 stan3 stanE59 tissue polarity defective | cell non-autonomous | somatic clone stanE59 tissue polarity defective | recessive stan21 stan24 stan3 stanE45 stanE59 tissue polarity defective | dominant stanVC31 tissue polarity defective | somatic clone stan192 stanE59 stansev.PD tissue polarity defective | somatic clone (with stanE59) stanE45 tissue polarity defective | somatic clone (with stanE45) stanE59 tissue polarity defective, with Scer\GAL4ptc-559.1 stanScer\UAS.cUa tissue polarity defective, with Scer\GAL4bi-md653 stanScer\UAS.cUa tissue polarity defective, with Scer\GAL4Dll-md23 stanScer\UAS.cUa tissue polarity defective, with Scer\GAL4sev.PM181 stanScer\UAS.cUa Sterility Allele fertile stanf00907 Phenotype manifest in Allele ommatidium | cell autonomous | somatic clone stan192 ommatidium stan192 stanE45 stanE59 stanfrz3 wing stan192 stanfrz3 thorax stan192 stanfrz3 leg stan192 stanfrz3 wing hair stan20 stan3 stanE45 stanE59 stanVC31 wing hair | somatic clone stan21 stan24 stan3 stanE59 wing hair | precursor stan3 trichome & abdominal tergite (with stanE59) stan3 multidendritic neuron stan6 stan72 stanE59 microchaeta stan71 dendrite & embryo | dorsal stan72 stanE45 stanE59 dorsal multidendritic neuron | somatic clone stan72 stanE59 dorsal multidendritic neuron ddaE | somatic clone stan72 stanE59 ommatidium | somatic clone (with stanE59) stanE45 eye photoreceptor cell | somatic clone (with stanE59) stanE45 longitudinal connective stanE45 stanE59 2nd posterior cell & wing hair stanE45 stanE59 macrochaeta stanE45 stanE59 ommatidium | somatic clone (with stanE45) stanE59 eye photoreceptor cell | somatic clone (with stanE45) stanE59 microchaeta & scutum stanE59 dorsocentral bristle stanE59 dorsal multidendritic neuron ddaC | somatic clone stanE59 dorsal multidendritic neuron stanE59 embryonic peripheral nervous system stanE59 photoreceptor cell & axon stanE59 photoreceptor cell R8 & axon stanE59 photoreceptor cell R8 & axon & growth cone stanE59 larval mushroom body | somatic clone stanE59 stanMB calyx of mushroom body | somatic clone stanE59 stanMB ommatidium | somatic clone stanE59 stansev.PD photoreceptor cell R3 | somatic clone stanE59 photoreceptor cell R4 | somatic clone stanE59 dendritic arborising neuron | somatic clone stanE59 eye photoreceptor cell | somatic clone stanE59 photoreceptor cell R3 | cell non-autonomous | somatic clone stanE59 photoreceptor cell R4 | cell non-autonomous | somatic clone stanE59 stansev.PD axon & photoreceptor cell R8 | somatic clone stanE59 trichome & pleural membrane | somatic clone stanE59 trichome & abdominal tergite (with stan3) stanE59 adult mushroom body | somatic clone stanMB dorsal lobe, with Scer\GAL4OK107 stanScer\UAS.cUa multidendritic neuron, with Scer\GAL4109(2)80 stanScer\UAS.cUa wing hair, with Scer\GAL4Dll-md23 stanScer\UAS.cUa trichome & adult abdomen, with Scer\GAL4ptc-559.1 stanScer\UAS.cUa wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1 stanScer\UAS.cUa ommatidium, with Scer\GAL4sev.PM181 stanScer\UAS.cUa photoreceptor cell R3 | ectopic, with Scer\GAL4sev.PM181 stanScer\UAS.cUa photoreceptor cell R4, with Scer\GAL4sev.PM181 stanScer\UAS.cUa wing hair, with Scer\GAL4bi-md653 stanScer\UAS.cUa microchaeta, with Scer\GAL4ap-md52 stanScer\UAS.cUa macrochaeta, with Scer\GAL4ap-md52 stanScer\UAS.cUa sensory mother cell & spindle, with Scer\GAL4ap-md52 stanScer\UAS.cUa embryonic neuron stanunspecified axon & photoreceptor cell R8 | somatic clone, with Scer\GAL4Act5C.PI, standsRNA.extra.Scer\UAS standsRNA.intra.Scer\UAS axon & photoreceptor cell R8 | somatic clone, with Scer\GAL4Act5C.PI, standsRNA.intra.Scer\UAS standsRNA.extra.Scer\UAS wing hair | supernumerary stanVC31
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of stan Class Mutagen Stocks Known lesion stan10 0 Yes stan15 irradiation 0 Yes stan192 loss of function X ray 1 -- stan20 0 -- stan21 0 -- stan24 loss of function irradiation 0 Yes stan35 0 Yes stan3 hypomorph 0 -- stan51 loss of function 0 Yes stan6 0 Yes stan71 0 -- stan72 ethyl methanesulfonate 0 Yes stan81f1 3 -- stanE45 loss of function ethyl methanesulfonate 0 Yes stanE59 loss of function ethyl methanesulfonate 0 Yes stanMB ethyl methanesulfonate 0 -- stanVC31 antimorph ethyl methanesulfonate 0 -- stanf00907 piggyBac transposase 2 -- stanfrz3 hypomorph 1 -- stanunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of stan Class Mutagen Stocks Known lesion stanGD607 in vitro construct | RNAi in vitro construct | regulatory fusion 3 Yes stanGMR.PS in vitro construct | regulatory fusion 0 Yes stanScer\UAS.cUa in vitro construct | regulatory fusion 0 Yes standsRNA.Scer\UAS in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes standsRNA.extra.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes standsRNA.intra.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes stansev.PD in vitro construct | regulatory fusion 0 Yes stanΔEX.Scer\UAS in vitro construct | deletion in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(2R)stan2
Useful duplication	Dp(2;2)Y3b
Disrupted in	Df(2R)17 (Usui et al., 1999) Df(2R)E3363 (Chae et al., 1999) Df(2R)stan1 (Chae et al., 1999) Df(2R)stan14 (Chae et al., 1999) Df(2R)stan2 (Chae et al., 1999) Df(2R)stan38 (Chae et al., 1999) Df(2R)stan9 (Chae et al., 1999) In(2)stan10 (Chae et al., 1999) In(2)stan35 (Chae et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD607} NA P{UAS-fmi.U} NA P{UAS-fmi.dsRNA.extra} NA P{UAS-fmi.dsRNA.intra} NA P{UAS-fmi.ΔEX} NA characterization construct P{GMR-fmi.S} NA P{sev-stan.D} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}stanf00907 NA
Related Comments
	Please look at the allele reports for the complete phenotype data Mutations in stan alter the polarity of cuticular structures in all regions of the adult body, affecting epidermal hairs, sensory bristles and ommatidia. (Chae et al., 1999) Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. (Lee and Adler, 2002) dsRNA has been made from templates generated with primers directed against this gene. stan RNAi results in overextension of ddaD and ddaE dendrites. (Parrish et al., 2006)
Gene Ontology: Function, Process & Cellular Component ( 29 )
Molecular Function
CV term Evidence References
G-protein coupled receptor activity inferred from sequence or structural similarity (Chae et al., 1999) inferred from electronic annotation with InterPro:IPR000832, InterPro:IPR001879 (FlyBase Curators et al., 2004-)
calcium ion binding inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR002126, InterPro:IPR015919 (FlyBase Curators et al., 2004-)
cell adhesion molecule binding inferred from sequence or structural similarity (Hynes and Zhao, 2000)
receptor activity inferred from sequence or structural similarity (Hynes and Zhao, 2000)
receptor signaling protein activity inferred from expression pattern (Usui et al., 1999) inferred from mutant phenotype (Chae et al., 1999)
transmembrane receptor activity