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Gene Dmel\DIP1

General Information
Symbol	Dmel\DIP1	Species	D. melanogaster
Name	DISCO Interacting Protein 1	Annotation symbol	CG17686
Feature type	protein_coding_gene	FlyBase ID	FBgn0024807
Created / Updated	2004-08-09/2004-08-09
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	20A4-20A5	Sequence location	X:21,495,823..21,501,185 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene DISCO Interacting Protein 1 is referred to in FlyBase by the symbol DIP1 (CG17686, FBgn0024807). It has the cytological map location 20A4-20A5. Its sequence location is X:21495823..21501185. Its molecular function is described as: double-stranded RNA binding; chromatin binding; protein binding. The biological processes in which it is involved are not known. 17 alleles are reported. The phenotypes of these alleles are annotated with: antenna; arista; head capsule; eye; wing; haltere; wing vein; wing margin bristle; capitellum; chaeta. It has 4 annotated transcripts and 4 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 20A4-20A5   Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
Experimentally Determined Cytological Location
Cytogenetic map Notes References 20A-20A   (Robert, 1999.12.8) 20A-20A   (Mukhopadhyay, 1999.9.1) 20A-20A   (Mukhopadhyay, 1999.8.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: DIP1+ TO42+ (Robert, 1999.9.2)
Gene Model & Products
Please see the GBrowse view of Dmel\DIP1 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) DIP1-RA FBtr0077370  NM_167774   3744   409 DIP1-RB FBtr0077371  NM_167773   3563   409 DIP1-RC FBtr0077372  NM_079929   2569   395 DIP1-RD FBtr0077373  NM_167772   2614   410
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein DIP1-PA   FBpp0077062   44.4   409   7.13     NP_728451   AAF45390 DIP1-PB   FBpp0077063   44.4   409   7.13     NP_728450   AAN09008 DIP1-PC   FBpp0077064   43.0   395   8.42     NP_524668   AAN09006 DIP1-PD   FBpp0077065   44.6   410   8.72     NP_728449   AAN09007
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0024807
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Double-stranded RNA binding (IPR001159)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390793   AA439741   AA440213   AA540094   AA801694   AA821249   AA940836   AE003122 AAF45390   AE003122 AAN09006   AE003122 AAN09007   AE003122 AAN09008   AF175711 AAD50502   AF175713 AAD50503   AF182154 AAD56033   AF182444 AAF03831   AF182444 AAF03832   AF182444 AAF03833   AF213338 AAF25886   AF218310 AAF67101   AI114195   AI259517   AI260626   AI292905   AI293062   AI294366   AI294495   AI297480   AI297912   AI387147   AI387917   AI389075   AI402716   AI406089   AI456315   AI513026   AI513497   AJ250866 CAC17704   AJ250867 CAC17705   AJ250868 CAC17706   AJ250869 CAC17707   AJ250870 CAC17708   AJ250870 CAC17709   AJ250870 CAC17710   AJ250870 CAC17711   AY121664 AAM51991   AY217028 AAO37650   BF499063   BF501947   BF504826   BF505265   BG632981   BG633097   BG639148   BI166944   BI169021   BI169618   BI170390   BI172135   BI216560   BI232104   BI235319   BI239391   BI242976   BI243000   BI374166   BI374900   BI485277   BI577766   BI580619   BI610776   BI619003   BI626282   BI639145   BI639150   BI641689   BP559556   BT021433 AAX33581   CO182813   CO262869   CO269998   CO270017   CO270653   CO279497   CO285677   CO290667   CO291871   CO292448   CO295918   CO296700   CO301029   CO303052   CO303576   CO305809   CO306637   CO308216   CO315466   CO318471   CO319383   CO325214   CO328286   CO331590   CO333671   CO341415   CO341671   CO345424   EC058915   EC061550   EC062681   EC066381   EC066539   EC067695   EC068301   EC072207   EC075750   EC079397   EC085319   EC087119   EC088604   EC089730   EC215027   EC215127   EC220086   EC222301   EC224102   EC225994   EC234459   EC238809   EC243621   EC246840   EC246932   EC248891   EC249292   EC252308   EC252900   EC254034   EC258303   EC259219   EC260420   GH17590   LD45242
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86LT0 Q8MRC7 Q9GNA3 Q9GNA6 Q9GND0 Q9GNJ2 Q9NHW9 Q9NIH3 Q9TW12 Q9TW27 Q9U4F5 Q9U6N4 Q9W5S7
Maps to
Does NOT map to
Identified with	GH26615 GH21996 GH15935 GH17590 GH18616 GH16142 GH26266 LD08867 LD19452 LD45242 LD36232 LD23092 LP11783 LP12356 LP07724 LP07878 LP02946 (Robert et al., 2001) GH20159 (BDGP Project Members, 2000-, Robert et al., 2001) LD14381 (Robert et al., 2001, DeSousa et al., 2003, Mevel-Ninio et al., 2007) LD14831 (Mukhopadhyay, 1999.9.1) RE10847 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 44
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI513026 AI389075
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024807 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0024807 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0024807
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4hs.PB DIP1b.Scer\UAS DIP1c.Scer\UAS lethal, with Scer\GAL4ey.PH DIP1b.Scer\UAS DIP1c.Scer\UAS Other Phenotypes Allele visible, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS visible, with Scer\GAL4ey.PH DIP1b.Scer\UAS reduced cell number, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS Sterility Allele fertile DIP1EY4R DIP1G1261 DIP1GE89R female fertile DIP1EY02625 Phenotype manifest in Allele eye, with Scer\GAL4ey.PH DIP1b.Scer\UAS DIP1c.Scer\UAS head capsule, with Scer\GAL4ey.PH DIP1b.Scer\UAS chaeta | ectopic, with Scer\GAL4ey.PH DIP1b.Scer\UAS antenna | ectopic, with Scer\GAL4ey.PH DIP1b.Scer\UAS antenna, with Scer\GAL4ey.PH DIP1c.Scer\UAS arista, with Scer\GAL4ey.PH DIP1c.Scer\UAS head capsule | ectopic, with Scer\GAL4ey.PH DIP1c.Scer\UAS wing, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS haltere, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS wing vein, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS wing margin bristle, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS capitellum, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of DIP1 Class Mutagen Stocks Known lesion DIP1EY02625 P-element activity 1 -- DIP1EY18P Δ2-3 0 Yes DIP1EY4R Δ2-3 0 Yes DIP1G1261 0 Yes DIP1GE89R P-element activity 0 Yes DIP1MB00541 1 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of DIP1 Class Mutagen Stocks Known lesion DIP1GD15889 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes DIP1b.Scer\UAS in vitro construct | regulatory fusion 0 Yes DIP1b.hs in vitro construct | regulatory fusion 0 Yes DIP1c.Scer\UAS in vitro construct | regulatory fusion 0 Yes DIP1c.hs in vitro construct | regulatory fusion 0 Yes DIP1cos7a in vitro construct | genomic fragment 0 Yes DIP1dsRBDΔ1.b.Scer\UAS