Gene Dmel\Sox100B

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General Information

Symbol

Dmel\Sox100B

Species

D. melanogaster

Name

Sox100B

Annotation symbol

CG15552

Feature type

protein_coding_gene

FlyBase ID

FBgn0024288

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

100B2-100B2

Sequence location

3R:26,891,079..26,909,129 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Sox100B (CG15552, FBgn0024288). It has the cytological map location 100B2. Its sequence location is 3R:26891079..26909129. Its molecular function is described as: DNA bending activity; transcription factor activity; hydrogen ion transmembrane transporter activity. It is involved in the biological processes: male gonad development; regulation of transcription; regulation of transcription, DNA-dependent. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100B2-100B2

Limits computationally determined from genome sequence between P{PZ}Aph-4⁰⁷⁰²⁸&P{PZ}dco^rK215 and P{PZ}l(3)rM731^rM731

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

100B-100B

(Russell, 1999.11.17)

100B-100B

(determined by in situ hybridisation)

(Russell, 1998.3.16)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Sox100B for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Sox100B-RA

FBtr0085735

NM_143582

1945

529

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Sox100B-PA

FBpp0085097

57.1

529

7.36

NP_651839

AAF57112

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0024288

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding (IPR000194)

High mobility group box, HMG1/HMG2 (IPR000910)

High mobility group box, HMG (IPR009071)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

11429

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0024288

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0024288

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0024288

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of Sox100B	Class	Mutagen	Stocks	Known lesion
Sox100B^12-78.2		Δ2-3	0	Yes

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Sox100B	Class	Mutagen	Stocks	Known lesion
Sox100B^GD4588		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)tll-e

Useful duplication

Dp(3;3)516

Partially disrupted in

Df(3R)Sox100B^12-78.2

(DeFalco et al., 2003)

Disrupted in

Df(3R)Exel6260

(Ryder, 2004.4.26)

Df(3R)Sox100B^12-78.2

(Loh, 1999)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD4588}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 8 )

Molecular Function

CV term

Evidence

References

DNA bending activity

inferred from sequence or structural similarity with UniProtKB:Q91ZK2

(FlyBase, 1992-)

hydrogen ion transmembrane transporter activity

inferred from electronic annotation with InterPro:IPR000194

(FlyBase Curators et al., 2004-)

transcription factor activity

inferred from sequence or structural similarity with UniProtKB:Q91ZK2

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

male gonad development

inferred from direct assay

(DeFalco et al., 2003)

regulation of transcription

inferred from sequence or structural similarity with UniProtKB:P48436

(FlyBase, 1992-)

regulation of transcription, DNA-dependent

inferred from electronic annotation with InterPro:IPR000910

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

nucleus

inferred from sequence or structural similarity with UniProtKB:Q91ZK2

(FlyBase, 1992-)

proton-transporting two-sector ATPase complex

inferred from electronic annotation with InterPro:IPR000194

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Sox100B allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

69448

Orthologs

Genome-wide drosophilid orthologs

Dana\GF18413

Dere\GG11790

Dgri\GH13971

Dmoj\GI22315

Dper\GL13537

Dpse\GA13810

Dsec\GM12920

Dsim\GD21559

Dvir\GJ10502

Dwil\GK22609

Dyak\GE10918

Curated drosophilid orthologs

Dpse\GA13810

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSCAFP00000006510
Canis familiaris (Ensembl)
NEWSINFRUP00000130972
Takifugu rubripes (Ensembl)
ENSP00000245479
Homo sapiens (Ensembl)
ENSMODP00000021089
Monodelphis domestica (Ensembl)
ENSPTRP00000041942
Pan troglodytes (Ensembl)
GSTENP00018540001
Tetraodon nigroviridis (Ensembl)
WBGene00029326
Caenorhabditis briggsae (Wormbase)
ZDB-CDNA-050809-8
Danio rerio (Zfin)
ZDB-GENE-031114-1
Danio rerio (Zfin)
MGI:98371
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v45962

w¹¹¹⁸; P{GD4588}v45962

v45961

w¹¹¹⁸; P{GD4588}v45961/TM3

Genomic Clones ( 2 )

cDNA Clones ( 4 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0024288

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0024288

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Sox100B CG12098

(Russell, 2000.4.27)

Source for merge of: Sox100B CG12098

(Crane-Robinson, 2000.5.9)

Source for merge of: Sox100B CG15552 Annotations CG15552 CG12098 merged as CG15552 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: Sox100B CG12098 Source for merge of: Sox100B CG18674 Source for merge of Sox100B CG12098 was sequence comparison (date:000607). Source for merge of Sox100B CG18674 was sequence comparison (date:001216).

(FlyBase, 1996-)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

Identification: Sequence similarity to human SOX9.

(Loh et al., 1998)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_143582

RefSeq (Proteins)

•

NP_651839

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding (IPR000194)

High mobility group box, HMG1/HMG2 (IPR000910)

High mobility group box, HMG (IPR009071)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

69448

DEDB - Drosophila exon database: splicing graphs

•

11429

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0024288

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0024288

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0024288

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0024288

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0024288

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0024288

InParanoid orthologs - Eukaryotic orthologs

•

ENSCAFP00000006510
Canis familiaris (Ensembl)
NEWSINFRUP00000130972
Takifugu rubripes (Ensembl)
ENSP00000245479
Homo sapiens (Ensembl)
ENSMODP00000021089
Monodelphis domestica (Ensembl)
ENSPTRP00000041942
Pan troglodytes (Ensembl)
GSTENP00018540001
Tetraodon nigroviridis (Ensembl)
WBGene00029326
Caenorhabditis briggsae (Wormbase)
ZDB-CDNA-050809-8
Danio rerio (Zfin)
ZDB-GENE-031114-1
Danio rerio (Zfin)
MGI:98371
Mus musculus (Informatics)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0024288

Synonyms & Secondary IDs ( 10 )

Reported As

Symbol Synonym

CG12098

(Crane-Robinson, 2000.5.9, Crane-Robinson, 2000.5.7, Russell, 2000.4.27, )

CG15552

CG18674

CT6009

(Ceriani et al., 2002)

Sox9

(Van Doren et al., 2002)

Sox100

(Sessa and Bianchi, 2007)

SOX100B

(Bowles et al., 2000, Hempel and Oliver, 2006, Lemos et al., 2008)

Sox100B

(Hoskins et al., 2005)

SoxB

(Russell, 1998.3.16, Loh et al., 1998, )

SOXE

(Bowles et al., 2000)

Name Synonym

Sox100B

Secondary FlyBase IDs

FBgn0039814
FBgn0039815
FBgn0040626

References ( 41 )

Generate a list of

All references relating to this gene ( 41 )

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Recent research papers ( 2 )

Lemos et al., 2008, Science 319(5859): 91--93: Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. [FBrf0200757]
Sessa and Bianchi, 2007, Gene 387(1-2): 133--140: The evolution of High Mobility Group Box (HMGB) chromatin proteins in multicellular animals. [FBrf0194706]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2006

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