A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\arg

General Information
SymbolDmel\argSpeciesD. melanogaster
NamearginaseAnnotation symbolCG18104
Feature typeprotein_coding_geneFlyBase IDFBgn0023535
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map1B7-1B8Sequence locationX:403,451..422,070 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene arginase is referred to in FlyBase by the symbol arg (CG18104, FBgn0023535). It has the cytological map location 1B7-1B8. Its sequence location is X:403451..422070. Its molecular function is described as: arginase activity; metal ion binding. It is involved in the biological process arginine catabolic process to ornithine. 22 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
1B7-1B8  
Limits computationally determined from genome sequence between P{EP}svrEP356&P{EP}argEP452 and P{EP}DreddEP1412&P{EP}Suv4-20EP1216a  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
1B-1B
 
(Samson, 2000.1.25)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: arg+ elav- arg+
(Samson, 2000)
Gene Order (overall orientation not stated)
References
Overall orientation not stated: arg? elav? arg?
(Samson, 2000.1.25)
hide Gene Model & Products
Please see the GBrowse view of Dmel\arg for information on other features
detailed view FBtr0070084 FBtr0290016 FBtr0070081 FBtr0070087 FBtr0290017 FBtr0070083 FBtr0070088 FBtr0100254 FBtr0114366 FBtr0070091 FBtr0070090 FBtr0070089 FBtr0100475 FBtr0100476 FBpp0288455 FBpp0089123 FBpp0089126 FBpp0070080 FBpp0288456 FBpp0070082 FBpp0070083 FBpp0099643 FBpp0112915 FBpp0070086 FBpp0099909 FBpp0099908 FBpp0070084 FBpp0070085 FBti0015667 FBti0015690 FBti0048930 FBti0013309 FBti0053754 FBti0066799 FBti0055391 FBti0059417 FBti0055580 FBti0069614 FBti0037307 FBti0039579 FBti0007373 FBti0007317 FBti0068633 FBti0030334 FBti0023123 FBti0034905 FBti0053914 FBti0029719 FBti0059393 FBti0029896 FBti0029973 FBti0033993 FBti0033758 FBti0035206 FBti0027947 FBti0070612 FBti0072036 FBti0068706 FBti0069179 FBti0035022 FBti0099879 FBti0030211 FBti0013429 FBti0071928 FBti0042002 FBti0076078
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
arg-RA
FBtr0070088
 NM_080136
  1269
  351
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
arg-PA  
FBpp0070083  
39.1  
351  
7.21  
  NP_524875
  AAF45516
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Arginase (IPR005924)
Ureohydrolase (IPR006035)
Arginase, subgroup (IPR014033)
MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins
•
  • MTDROME18104
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003417
AAF45516
 
AF047180
AAC03552
 
AF228517
AAF34792
 
AF239214
AAF40226
 
AI063101
 
AI063105
 
AI133946
 
AI401868
 
AI514270
 
AL009147
CAA15631
 
AL022139
CAA18092
 
AQ025344
 
AQ025390
 
BH610067
 
BH809434
 
BI362300
 
BI372657
 
BI564667
 
BI583131
 
BI615420
 
BI620216
 
BP548989
 
BP548990
 
BT004504
AAO42668
 
CL528154
 
CO266460
 
CO275296
 
CO278023
 
CO292670
 
CO295610
 
CO302416
 
CO304435
 
CO315191
 
CO315218
 
CO318034
 
CO318208
 
CO318339
 
CO324457
 
CO333461
 
CO334125
 
CZ471413
 
CZ472461
 
CZ472712
 
CZ472713
 
CZ473685
 
CZ474023
 
CZ474271
 
CZ475417
 
CZ477653
 
CZ480259
 
CZ482331
 
EC057597
 
EC065312
 
EC067147
 
EC085345
 
EC089625
 
EC089948
 
EC201503
 
EC205467
 
EC223801
 
EC227467
 
EC244034
 
EC245949
 
EC256561
 
EC260591
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (Samson, 2000)
    (BDGP Project Members, 2000-, Samson, 2000, Benos et al., 2001)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0070084 FBtr0290016 FBtr0070081 FBtr0070087 FBtr0290017 FBtr0070083 FBtr0070088 FBtr0100254 FBtr0114366 FBtr0070091 FBtr0070090 FBtr0070089 FBtr0100475 FBtr0100476
        AI063105
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        Sterility
        Allele
        fertile
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 20 )
        For All Classical Alleles Show

        Allele of argClassMutagenStocksKnown lesion
        argCB035790 Yes
        argEP11171 --
        argEP4521 --
        argEY090881 --
        argG00311 --
        argG03191 --
        argKG003971 --
        argKG033781 --
        argd001531 --
        argd018200 --
        argd022630 --
        argd040081 --
        argd045981 --
        argd050240 --
        argd068920 --
        argd112700 --
        arge024440 --
        arge045781 --
        argelav-4
          		0 Yes
          argelav-5
            		0 Yes
            hide Alleles Carried on Transgenic Constructs ( 2 )
            For All Alleles Carried on Transgenic Constructs Show

            Allele of argClassMutagenStocksKnown lesion
            argGD164731 Yes
            argGD57271 Yes
            hide Aneuploid Aberrations
            Useful deficiency
             
            Useful duplication
             
            Disrupted in
            (Samson, 2000)
            hide Transgenic Constructs & Insertions
            Transgenic Constructs
            Type of construct
            Name
            Expression data
            UAS construct
            P{GD16473}
            NA
            P{GD5727}
            NA
            Insertions
            Type of insertions
            Name
            Expression data
            miscellaneous insertions
            PBac{RB}arge02444
            NA
            PBac{RB}arge04578
            NA
            P{PTT-GB}argCB03579
            NA
            P{SUPor-P}argKG00397
            NA
            P{SUPor-P}argKG03378
            NA
            insertion of enhancer trap
            P{lacW}elavG0031
            No
            P{lacW}elavG0319
            No
            insertion of mobile activating element
            P{EPgy2}elavEY09088
            NA
            P{EP}argEP1117
            NA
            P{EP}argEP452
            NA
            P{Mae-UAS.6.11}B2001B2001
            NA
            P{Mae-UAS.6.11}B2002B2002
            NA
            P{Mae-UAS.6.11}B2003B2003
            NA
            P{Mae-UAS.6.11}GG01017GG01017
            NA
            P{XP}argd00153
            NA
            P{XP}argd01820
            NA
            P{XP}argd02263
            NA
            P{XP}argd04008
            NA
            P{XP}argd04598
            NA
            P{XP}argd05024
            NA
            P{XP}argd06892
            NA
            P{XP}argd11270
            NA
            hide Related Comments
            Please look at the allele reports for the complete phenotype data
            hide Gene Ontology: Function, Process & Cellular Component ( 4 )
            hide Molecular Function
            CV term
            Evidence
            References
            arginase activity
            inferred from sequence or structural similarity
            (EDGP Project Members, 1994-)
            inferred from sequence or structural similarity with UniProtKB:P78540
            (Sardiello et al., 2003.6.11)
            metal ion binding
            inferred from electronic annotation with InterPro:IPR005924, InterPro:IPR006035
            (FlyBase Curators et al., 2004-)
            hide Biological Process
            CV term
            Evidence
            References
            arginine catabolic process to ornithine
            inferred from sequence or structural similarity with UniProtKB:P78540
            (Sardiello et al., 2003.6.11)
            hide Cellular Component
            CV term
            Evidence
            References
            mitochondrion
            inferred from sequence or structural similarity with UniProtKB:P78540
            (Sardiello et al., 2003.6.11)
            hide Sequence Ontology: Class of Gene
            protein_coding_gene
             
            nuclear_gene
             
            hide Interactions & Pathways
            hide Summary of Genetic Interactions
            Interacts with
            Please look at the allele data for full details of the genetic interactions
            arg allele
            Gene
            References
            hide External Data
            Linkouts
            BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
            •
            hide Orthologs
            Genome-wide drosophilid orthologs
            Curated drosophilid orthologs
             
            Linkouts
            InParanoid orthologs - Eukaryotic orthologs
            •
            hide Functional Complementation between Species
            hide Inter-Species Misexpression Data
            Produces phenotype in
            Produces NO phenotype in
            hide Stocks & Reagents
            hide Stocks Listed in FlyBase ( 13 )
            Szeged
            -
            P{EP}argEP452
            -
            P{EP}argEP1117
            Harvard
            -
            P{XP}argd00153
            -
            P{XP}argd04008
            -
            P{XP}argd04598
            -
            PBac{RB}arge04578
            VDRC
            v14933
            w1118; P{GD5727}v14933
            v47186
            w1118 P{GD16473}v47186
            Bloomington
            13101
            y1 P{SUPor-P}argKG00397
            13951
            y1 P{SUPor-P}argKG03378
            12098
            P{lacW}elavG0031 argG0031 w67c23/FM7c
            12240
            P{lacW}elavG0319 argG0319 w67c23/FM7c
            hide Genomic Clones ( 2 )
            hide cDNA Clones ( 25 )
            Please Note
            This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
            cDNA Clones, Fully Sequenced
            BDGP DGC clones
            Other clones
            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            hide RNAi & Array Information
            Affy Oligo
            Linkouts
            DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
            •
            GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
            •
            hide Antibody Information