HomeGene Dmel\Uba1
| General Information | |||
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| Symbol | Dmel\Uba1 | Species | D. melanogaster |
| Name | Ubiquitin activating enzyme 1 | Annotation symbol | CG1782 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0023143 |
| Created / Updated | 2003-12-02/2003-12-02 | ||
| Genomic Location | |||
| Chromosome (arm) | 2R | Recombination map | |
| Cytogenetic map | 46A1-46A1 | Sequence location | 2R:5,575,792..5,580,833 [-] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene Ubiquitin activating enzyme 1 is referred to in FlyBase by the symbol Uba1 (CG1782, FBgn0023143). It has the cytological map location 46A1. Its sequence location is 2R:5575792..5580833. Its molecular function is described as: ubiquitin activating enzyme activity; ubiquitin-protein ligase activity; binding. It is involved in the biological processes: neuron remodeling; ubiquitin cycle. 29 alleles are reported. The phenotypes of these alleles are annotated with: neuroblast; dendrite; anterior fascicle; macrochaeta; eye. It has one annotated transcript and one annotated polypeptide. | ||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 46A1-46A1
Limits computationally determined from genome sequence between P{PZ}Mmp202353&P{PZ}Uba105642 and P{lacW}l(2)k09221k09221&P{PZ}dap04454
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 46A-46A 46A1-46A2 (determined by in situ hybridisation)
46A1-46A2 46A2--3 46A2--4 46A3--4
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| Experimentally Determined Recombination Data | |||
| Location | |||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Uba1
for information on other features
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| Comments on Gene Model | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | |||
| Comments | |||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | |||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Ubiquitin-activating enzyme, E1 (IPR000011)
Ubiquitin-activating enzyme repeat (IPR000127)
UBA/THIF-type NAD/FAD binding fold (IPR000594)
Molybdenum cofactor biosynthesis (IPR009036)
NAD(P)-binding (IPR016040)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele Phenotype manifest in Allele anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 anterior fascicle & synapse, with Scer\GAL4elav-C155 dendritic arborising neuron & pupa mushroom body & axon | somatic clone | |||
Stage(s)
4-6
Stage(s)
7-8
Stage(s)
9-10
Stage(s)
11-12
Stage(s)
13-16