HomeGene Dmel\Pkn
| General Information | |||
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| Symbol | Dmel\Pkn | Species | D. melanogaster |
| Name | Protein kinase related to protein kinase N | Annotation symbol | CG2049 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0020621 |
| Created / Updated | 2003-12-02/2003-12-02 | ||
| Genomic Location | |||
| Chromosome (arm) | 2R | Recombination map | |
| Cytogenetic map | 45C1-45C1 | Sequence location | 2R:5,141,005..5,172,602 [-] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene Protein kinase related to protein kinase N is referred to in FlyBase by the symbol Pkn (CG2049, FBgn0020621). It has the cytological map location 45C1. Its sequence location is 2R:5141005..5172602. Its molecular function is described as: protein serine/threonine kinase activity; protein kinase activity; protein kinase C activity; ATP binding. It is involved in the biological processes: protein amino acid phosphorylation; dorsal closure; signal transduction. 29 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; embryonic epidermis; wing; wing margin bristle; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. | ||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 45C1-45C1
Limits computationally determined from genome sequence between P{lacW}CG8788k04512&P{lacW}l(2)k13412k13412 and P{PZ}Pkn06736 45C1 Left limit from in situ hybridisation (FBrf0067338) Right limit from inclusion within Df(2R)w73-1 (FBrf0089219) Left limit from in situ hybridisation (FBrf0048100) Right limit from in situ hybridisation (FBrf0048100)
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 45C1-45C2 (determined by in situ hybridisation) 45C3--4 (determined by in situ hybridisation)
45C-45C (determined by in situ hybridisation)
45C1-45C2 (determined by in situ hybridisation)
45C1-45C2 45C3--4
45C-45C (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | |||
| Location | |||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Pkn
for information on other features
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| Comments on Gene Model | |||
EST data support existence of multiple transcripts | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0112897
5362
1501 | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | |||
| Comments | |||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0111810
166.8
1501
6.61
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | |||
| Comments | |||
| External Data | |||
| Linkouts | |||
| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• C2 calcium-dependent membrane targeting (IPR000008)
Protein kinase, core (IPR000719)
HR1-like rho-binding repeat (IPR000861)
Protein kinase, C-terminal (IPR000961)
Serine/threonine protein kinase (IPR002290)
Serine/threonine protein kinase, active site (IPR008271)
Protein kinase-like (IPR011009)
HR1 rho-binding repeat (IPR011072)
C2 calcium/lipid-binding region, CaLB (IPR008973)
Protein kinase ATP binding, conserved site (IPR017441)
Serine/threonine protein kinase-related (IPR017442)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele Sterility Allele Phenotype manifest in Allele | |||
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Classical Alleles
( 25 ) | |||
| For All Classical Alleles Show | |||
