A Database of Drosophila Genes & Genomes

 

Gene Dmel\iab-4

General Information
SymbolDmel\iab-4SpeciesD. melanogaster
Nameiab-4Annotation symbolCR31271
Feature typenon_protein_coding_geneFlyBase IDFBgn0020546
Created / Updated2005-01-25/2005-01-25
Genomic Location
Chromosome (arm)3RRecombination map3-
Cytogenetic map 89E3-89E3 Sequence location3R:12,675,726..12,682,219 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol iab-4 (CR31271, FBgn0020546). It has the cytological map location 89E3. Its sequence location is 3R:12675726..12682219. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. The phenotypes of these alleles are annotated with: adult abdominal segment 1; adult abdominal segment 4; gonad; ovary; oviduct; testis; adult abdominal segment 2; adult abdominal segment 5; pole cell. It has 2 annotated transcripts.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
89E3-89E3  
Limits computationally determined from genome sequence between P{lacW}CSN5L4032 and P{EP}MESK4EP1015  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
89E2-89E2
Based on proximity to abd-A.  
(Martin et al., 1995)
Experimentally Determined Recombination Data
Location
3-
(Martin et al., 1995)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: Fas1+ nonA-l+ Cctγ+ CG14906- CG31217- CG31217- Ubx- bxd- Glut3+ abd-A- iab-4+ CG10349+ Abd-B- Actn3- Ahcy89E-
(Martin et al., 1995)
Gene Order (overall orientation not stated)
References
Overall orientation not stated: abd-A- iab-4? CG10349? anon-89Ec? Abd-B-
(Casares and Sanchez-Herrero, 1995)
hide Gene Model & Products
Please see the GBrowse view of Dmel\iab-4 for information on other features
detailed view
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
 
iab-4-RA
FBtr0083362
 NR_002037
  2113
 
iab-4-RB
FBtr0083363
 NR_002036
  1807
 
Additional Transcript Data & Comments
Reported size (kB)
2.0, 1.7 (northern blot)
(Cumberledge et al., 1990)
Comments
External Data
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
 
Name
M32109
 
 
Maps to
Does NOT map to
Identified with
hide Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
FlyBase-Curated Data
Transcript data Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
hide Summary of Transcript Expression
Stage
Tissue/Position
Reference
 embryonic stage | stage 1-17
 
(Cumberledge et al., 1990)
 embryonic stage | stage stage 8
 ventral nervous system <of> parasegment 8-14
(Cumberledge et al., 1990)
 embryonic stage | stage 4
 
(Cumberledge et al., 1990)
 embryonic stage | stage stage 8
 parasegment 8-14
(Cumberledge et al., 1990)
 embryonic stage | stage 4
 
(Cumberledge et al., 1990)
Marker for
    Subcellular Localization
    CV Term
    hide External Data & Images
    Linkouts
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    •
    hide Alleles & Phenotypes
    hide Summary of Allele Phenotypes
    Lethality
    Allele
    viable
    Other Phenotypes
    Allele
    visible | recessive
    visible | homeotic
    Sterility
    Allele
    female sterile
    female sterile | recessive
    male sterile
    male sterile | recessive
    Phenotype manifest in
    Allele
    gonad | precursor
    pole cell
    adult abdominal segment 2
    adult abdominal segment 5
    adult abdominal segment 4
    ovary
    oviduct
    testis
    adult abdominal segment 1
    hide Classical Alleles ( 7 )
    For All Classical Alleles Show

    Allele of iab-4ClassMutagenStocksKnown lesion
    iab-41250 Yes
    iab-41660 Yes
    iab-43020 Yes
    iab-4450 Yes
    iab-4DB
      		0 Yes
      iab-4MX4gain of function0 --
      iab-4McR1loss of function
        		0 Yes
        hide Alleles Carried on Transgenic Constructs ( 0 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of iab-4ClassMutagenStocksKnown lesion
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        Disrupted in
        (Karch et al., 1990)
        (Karch et al., 1985, Cumberledge et al., 1990)
        (Cumberledge et al., 1990)
        (Karch et al., 1985, Cumberledge et al., 1990)
        (Cumberledge et al., 1990)
        (Cumberledge et al., 1990)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 0 )
        hide Molecular Function
        CV term
        Evidence
        References
        hide Biological Process
        CV term
        Evidence
        References
        hide Cellular Component
        CV term
        Evidence
        References
        hide Sequence Ontology: Class of Gene
        non_protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        iab-4 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
        Linkouts
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 0 )
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 0 )
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Additional comments
        hide Comments About Role
        Non-coding RNA regulating abd-A.
        (Martin et al., 1995)
        hide Comments About Molecular Function
        The iab-4 locus produces two microRNAs; mir-iab-4-3p and mir-iab-4-5p.
        (Ronshaugen et al., 2005)
        hide Other Comments
        The transcription unit that produces the noncoding iab-4 transcript has been identified.
        (Lewis et al., 1995)
        New annotation (CR31271) in release 3 of the genome annotation.
        (FlyBase Genome Annotators, 2002-2003)
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        DDBJ / EMBL / GenBank
        •
        Other Crossreferences
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        •
        hide Synonyms & Secondary IDs ( 7 )
        Reported As
        Symbol Synonym
        CR31271
         
        I
        (Casares and Sanchez-Herrero, 1995)
        iab
        (Mattick and Gagen, 2001)
        iab-4
        (Lemons and McGinnis, 2006, Prasanth and Spector, 2007, Chopra and Mishra, 2006)
        iab4
        (Sanchez-Elsner et al., 2006)
        mir-iab-4
        (Pearson et al., 2005)
        Name Synonym
        domain I
        (Sanchez-Herrero and Akam, 1989)
        iab-4
         
        Secondary FlyBase IDs
        • FBan0031271
        • FBgn0051271
        hide References ( 39 )
        Generate a list of
        List References by type
        hide Recent research papers (0)
        All research papers listed in FlyBase were published before 2006
        Show research papers ...
        hide Recent reviews ( 3 )
        Prasanth and Spector, 2007, Genes Dev. 21(1): 11--42
        Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. [FBrf0193472]
        Chopra and Mishra, 2006, BioEssays 28(5): 445--448
        "Mir"acles in hox gene regulation. [FBrf0192956]
        Lemons and McGinnis, 2006, Science 313(5795): 1918--1922
        Genomic evolution of Hox gene clusters. [FBrf0200009]
        Show all reviews ...