A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\crol

General Information
SymbolDmel\crolSpeciesD. melanogaster
Namecrooked legsAnnotation symbolCG14938
Feature typeprotein_coding_geneFlyBase IDFBgn0020309
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map33A1-33A2Sequence location2L:11,794,327..11,809,433 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene crooked legs is referred to in FlyBase by the symbol crol (CG14938, FBgn0020309). It has the cytological map location 33A1-33A2. Its sequence location is 2L:11794327..11809433. Its molecular function is described as: RNA polymerase II transcription factor activity; zinc ion binding; nucleic acid binding; ice binding. It is involved in the biological processes: regulation of transcription from RNA polymerase II promoter; cell adhesion; imaginal disc-derived wing morphogenesis; homoiothermy; response to freezing. 36 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: adult segment; thoracic segment; anatomical structure; adult; nervous system; peripheral nervous system; adult mesothoracic segment; appendage segment; organ system; adult metathoracic segment. It has 4 annotated transcripts and 4 annotated polypeptides.

External Summaries
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
33A1-33A2  
Limits computationally determined from genome sequence between P{PZ}salm03602 and P{PZ}crol04418&P{EP}crolEP1183  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
33A6-33A7
33A1-33A2
(determined by in situ hybridisation)  
33A1-33A2
33A2--3 33A3--4  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\crol for information on other features
detailed view FBtr0080265 FBtr0080264 FBtr0080262 FBtr0080261 FBtr0080263 FBtr0080260 FBtr0080259 FBpp0079848 FBpp0079845 FBpp0079847 FBpp0079846 FBpp0079844 FBpp0079843 FBti0054404 FBti0055194 FBti0045036 FBti0067092 FBti0053827 FBti0048609 FBti0046515 FBti0049069 FBti0007009 FBti0005267 FBti0035225 FBti0100814 FBti0010865 FBti0033918 FBti0007785 FBti0054454 FBti0034701 FBti0026055 FBti0056051 FBti0068310 FBti0053658 FBti0045010 FBti0007011 FBti0036934 FBti0024207 FBti0035460 FBti0039958 FBti0059271 FBti0029678 FBti0035051 FBti0028929 FBti0010955 FBti0055125 FBti0100146
Comments on Gene Model
EST data support existence of multiple transcripts
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0080261
  7105
  962
FBtr0080262
  6892
  891
FBtr0080263
  6487
  756
FBtr0080260
  6202
  878
Additional Transcript Data & Comments
Reported size (kB)
6.0, 5.3 (northern blot)
Comments
It is not clear how the 6.0 and 5.3kb crol transcripts observed on northern blots related to the isoforms characterized by cDNAs.
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0079845  
106.4  
962  
9.46  
FBpp0079846  
98.5  
891  
9.29  
FBpp0079847  
82.9  
756  
9.49  
FBpp0079844  
96.4  
878  
9.41  
Additional Polypeptide Data & Comments
Reported size (kD)
962, 891, 756 (aa)
Comments
The beta form of crol protein has 16 zinc fingers.
The alpha form of crol protein has 18 zinc fingers.
The gamma form of crol protein has 12 zinc fingers.
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     larval stage | third instar
     prepupal stage
     prepupal stage
     larval stage | third instar
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0080265 FBtr0080264 FBtr0080262 FBtr0080261 FBtr0080263 FBtr0080260 FBtr0080259
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        FlyExpress - Embryonic expression images (BDGP data)
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        Other Phenotypes
        Allele
        Sterility
        Allele
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 35 )
        For All Classical Alleles Show

        Allele of crolClassMutagenStocksKnown lesion
        crol044181 Yes
        crol064700 Yes
        crol106390 --
        crol11
          1 Yes
          crol1ex15hypomorph0 Yes
          crol3ex50 Yes
          crolBG003460 Yes
          crolBG012550 Yes
          crolBG012560 Yes
          crolCB030390 Yes
          crolEP11831 --
          crolEP21191 --
          crolEP22261 Yes
          crolEY089531 --
          crolGS2267
            0 Yes
            crolc046101 --
            crolc046701 --
            crold012051 --
            crold013511 --
            crold032281 --
            crold034161 --
            crold061781 --
            crole005601 --
            crole040171 --
            crole041480 --
            crolf000901 --
            crolf077101 --
            crolf077730 --
            crolf080811 --
            crolk05205